10.1186/2193-8865-3-62

X-ray imaging technique using colloid solution of Au/silica core-shell nanoparticles

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  • Yoshio Kobayashi*1,
  • Hiromitsu Inose1,
  • Tomohiko Nakagawa2,
  • Yohsuke Kubota2,
  • Kohsuke Gonda2,
  • Noriaki Ohuchi2,
  1. Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, Ibaraki, 316-8511, JP
  2. Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JP
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Published in Issue 02-08-2013

How to Cite

Kobayashi, Y., Inose, H., Nakagawa, T., Kubota, Y., Gonda, K., & Ohuchi, N. (2013). X-ray imaging technique using colloid solution of Au/silica core-shell nanoparticles. Journal of Nanostructure in Chemistry, 3(1 (December 2013). https://doi.org/10.1186/2193-8865-3-62
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Abstract

Abstract This work describes X-ray imaging of mouse using a colloid solution of silica-coated Au (Au/SiO 2 ) nanoparticles. A colloid solution of Au nanoparticles with a size of 16.9 nm was prepared using hydrogen tetrachloroaurate (III) trihydrate as Au source and sodium citrate as reducing reagent. Silica coating of the Au nanoparticles was performed by modifying the Au nanoparticle surface with (3-aminopropyl)trimethoxysilane and then by depositing silica nuclei generated through a sol–gel reaction of tetraethyl orthosilicate in water/ethanol initiated with sodium hydroxide on the surface-modified surface, which produced Au/SiO 2 particles with a size of 136.4 nm. A computed tomography value of the Au/SiO 2 colloid solution with an Au concentration of 0.036 M was as high as 1,184.8 Hounsfield units, which was quite higher than that of a commercial X-ray contrast agent with the same iodine concentration as the Au concentration. Tissues of mouse could be imaged by injecting the Au/SiO 2 particle colloid solution into them.

Keywords

  • Au,
  • Silica,
  • Core-shell,
  • Nanoparticle,
  • X-ray contrast agent
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References

  1. Bellani and Caironi (2011) Lung imaging during acute respiratory distress syndrome: CT- and PET-scanning (pp. 203-209) https://doi.org/10.1016/j.tacc.2011.05.006
  2. Duwek et al. (2011) A biologically-based algorithm for companding computerized tomography (CT) images (pp. 367-379) https://doi.org/10.1016/j.compbiomed.2011.03.015
  3. Ruschin et al. (2013) Cone beam computed tomography image guidance system for a dedicated intracranial radiosurgery treatment unit (pp. 243-250) https://doi.org/10.1016/j.ijrobp.2012.03.022
  4. Lee et al. (2010) Flow tracing microparticle sensors designed for enhanced X-ray contrast (pp. 1571-1578) https://doi.org/10.1016/j.bios.2009.11.010
  5. Hwang et al. (2011) The effect of a contrast agent on proton beam range in radiotherapy planning using computed tomography for patients with locoregionally advanced lung cancer (pp. e317-e324) https://doi.org/10.1016/j.ijrobp.2011.02.025
  6. Rustighi et al. (2012) Borate complexes of X-ray iodinated contrast agents: characterization and sorption studies for their removal from aqueous media (pp. 10-16) https://doi.org/10.1016/j.jhazmat.2011.10.084
  7. Thomsen (2011) Contrast media safety - an update (pp. 77-82) https://doi.org/10.1016/j.ejrad.2010.12.104
  8. Ichikawa et al. (2012) Optimal iodine dose for 3-dimensional multidetector-row CT angiography of the liver (pp. 2450-2455) https://doi.org/10.1016/j.ejrad.2011.06.022
  9. Li et al. (2013) Iodinated a-tocopherol nano-emulsions as non-toxic contrast agents for preclinical X-ray imaging (pp. 481-491) https://doi.org/10.1016/j.biomaterials.2012.09.026
  10. Malarkodi et al. (2013) Eco-friendly synthesis and characterization of gold nanoparticles using Klebsiella pneumoniae https://doi.org/10.1186/2193-8865-3-30
  11. Rajeshkumar et al. (2013) Seaweed-mediated synthesis of gold nanoparticles using Turbinaria conoides and its characterization https://doi.org/10.1186/2193-8865-3-44
  12. Park et al. (2010) Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent (pp. 2287-2291) https://doi.org/10.1016/j.bmcl.2010.02.002
  13. Cho et al. (2010) Inorganic nanoparticle-based contrast agents for molecular imaging (pp. 561-573) https://doi.org/10.1016/j.molmed.2010.09.004
  14. Wang et al. (2011) Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles (pp. 2979-2988) https://doi.org/10.1016/j.biomaterials.2011.01.001
  15. Ahn et al. (2011) Gold nanoparticle-incorporated human red blood cells (RBCs) for X-ray dynamic imaging (pp. 7191-7199) https://doi.org/10.1016/j.biomaterials.2011.05.023
  16. Menk et al. (2011) Gold nanoparticle labeling of cells is a sensitive method to investigate cell distribution and migration in animal models of human disease (pp. 647-654) https://doi.org/10.1016/j.nano.2011.01.010
  17. Roessl et al. (2011) Preclinical spectral computed tomography of gold nano-particles (pp. S259-S264) https://doi.org/10.1016/j.nima.2010.11.072
  18. Zhang et al. (2012) Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy (pp. 6408-6419) https://doi.org/10.1016/j.biomaterials.2012.05.047
  19. Peng et al. (2012) PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography (pp. 1107-1119) https://doi.org/10.1016/j.biomaterials.2011.10.052
  20. Kim and Jon (2012) Gold nanoparticles in image-guided cancer therapy (pp. 154-164) https://doi.org/10.1016/j.ica.2012.07.001
  21. Tedesco et al. (2010) Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis (pp. 178-186) https://doi.org/10.1016/j.aquatox.2010.03.001
  22. Ahamed et al. (2010) Silver nanoparticle applications and human health (pp. 1841-1848) https://doi.org/10.1016/j.cca.2010.08.016
  23. Farkas et al. (2010) Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes (pp. 44-52) https://doi.org/10.1016/j.aquatox.2009.09.016
  24. Lasagna-Reeves et al. (2010) Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice (pp. 649-655) https://doi.org/10.1016/j.bbrc.2010.02.046
  25. Han et al. (2011) Validation of an LDH assay for assessing nanoparticle toxicity (pp. 99-104) https://doi.org/10.1016/j.tox.2011.06.011
  26. Park et al. (2011) The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles (pp. 9810-9817) https://doi.org/10.1016/j.biomaterials.2011.08.085
  27. Schulz et al. (2012) Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats (pp. 51-57) https://doi.org/10.1016/j.mrgentox.2011.11.016
  28. Nymark P, Catalán J, Suhonen S, Järventaus H, Birkedal R, Clausen PA, Jensen KA, Vippola M, Savolainena K, Norppa H:
  29. Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells.
  30. Toxicol
  31. in press in press
  32. Lu et al. (2002) Synthesis and self-assembly of Au@SiO2 core-shell colloids (pp. 785-788) https://doi.org/10.1021/nl025598i
  33. Xu and Perry (2007) A novel approach to Au@SiO2 core-shell spheres (pp. 1212-1215) https://doi.org/10.1016/j.jnoncrysol.2007.01.005
  34. Ye et al. (2008) Surface morphology changes on silica-coated gold colloids (pp. 225-233) https://doi.org/10.1016/j.colsurfa.2008.03.033
  35. Wu et al. (2011) Preparation of uniform Au@SiO2 particles by direct silica coating on citrate-capped Au nanoparticles (pp. 220-224) https://doi.org/10.1016/j.colsurfa.2011.09.059
  36. Wang et al. (2011) Fluorescent hollow/rattle-type mesoporous Au@SiO2 nanocapsules for drug delivery and fluorescence imaging of cancer cells (pp. 109-115) https://doi.org/10.1016/j.jcis.2011.02.023
  37. Huang et al. (2012) Synthesis of silica-coated gold nanorod as Raman tags by modulating cetyltrimethylammonium bromide concentration (pp. 61-68) https://doi.org/10.1016/j.colsurfa.2012.06.003
  38. Yu et al. (2012) A novel electrochemical sensor for determination of dopamine based on AuNPs@SiO2 core-shell imprinted composite (pp. 270-277) https://doi.org/10.1016/j.bios.2012.05.045
  39. Fülöp et al. (2012) Langmuir–Blodgett films of gold/silica core/shell nanorods (pp. 7002-7005) https://doi.org/10.1016/j.tsf.2012.07.097
  40. Shen et al. (2013) Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation (pp. 3150-3158) https://doi.org/10.1016/j.biomaterials.2013.01.051
  41. Khlebtsov et al. (2013) A simple Mie-type model for silica-coated gold nanocages (pp. 23-29) https://doi.org/10.1016/j.jqsrt.2013.03.001
  42. Mine et al. (2003) Direct coating of gold nanoparticles with silica by a seeded polymerization technique (pp. 385-390) https://doi.org/10.1016/S0021-9797(03)00422-3
  43. Kobayashi et al. (2011) Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties (pp. 329-333) https://doi.org/10.1016/j.jcis.2011.01.058
  44. Kobayashi et al. (2012) Synthesis of Au-silica core-shell particles by sol–gel process (pp. 129-133) https://doi.org/10.1179/1743294411Y.0000000069
  45. Kobayashi Y, Inose H, Nagasu R, Nakagawa T, Kubota Y, Gonda K, Ohuchi N:
  46. X-ray imaging technique using colloid solution of Au/silica/poly(ethylene glycol) nanoparticles.
  47. Mater Res Innov
  48. in press in press
  49. Zhang et al. (2012) Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging (pp. 239-244) https://doi.org/10.1016/j.jcis.2012.01.005
  50. Hallouard et al. (2010) Iodinated blood pool contrast media for preclinical X-ray imaging applications - a review (pp. 6249-6268) https://doi.org/10.1016/j.biomaterials.2010.04.066
  51. Parveen and Sahoo (2011) Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery (pp. 372-383) https://doi.org/10.1016/j.ejphar.2011.09.023
  52. Dufort et al. (2012) Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution (pp. 179-189) https://doi.org/10.1016/j.addr.2011.09.009
  53. Stolnik et al. (2012) Long circulating microparticulate drug carriers (pp. 290-301) https://doi.org/10.1016/j.addr.2012.09.029
  54. Bauer et al. (2013) Engineering biocompatible implant surfaces: part I: materials and surfaces (pp. 261-326) https://doi.org/10.1016/j.pmatsci.2012.09.001