10.1186/2193-8865-3-11

Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them

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  • Yoshio Kobayashi*1,
  • Hikaru Morimoto1,
  • Tomohiko Nakagawa2,
  • Yohsuke Kubota2,
  • Kohsuke Gonda2,
  • Noriaki Ohuchi3,
  1. Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, Hitachi, Ibaraki, 316-8511, JP
  2. Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8575, JP
  3. Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8575, JP Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8574, JP
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Published in Issue 16-04-2013

How to Cite

Kobayashi, Y., Morimoto, H., Nakagawa, T., Kubota, Y., Gonda, K., & Ohuchi, N. (2013). Fabrication of hollow particles composed of silica containing gadolinium compound and magnetic resonance imaging using them. Journal of Nanostructure in Chemistry, 3(1 (December 2013). https://doi.org/10.1186/2193-8865-3-11
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Abstract

Abstract A preparation method for hollow particles composed of silica shell containing gadolinium compound (GdC) is proposed. GdC nanoparticles with an average size of 40.5 ± 6.2 nm were prepared with a homogeneous precipitation method at 80°C using 1.0 × 10 −3  M Gd(NO 3 ) 3 and 0.5 M urea in the presence of 2.0 × 10 −4  M ethylenediaminetetraacetic acid disodium salt dihydrate. Silica-coated GdC (GdC/SiO 2 ) nanoparticles with an average size of 100.9 ± 9.9 nm were fabricated with a sol-gel method at 35°C using 5.0 × 10 −3  M tetraethylorthosilicate, 11 M H 2 O, and 1.5 × 10 −3  M NaOH in ethanol in the presence of 1.0 × 10 −3  M GdC nanoparticles. The GdC/SiO 2 particles were aged at 80°C in water after replacement of solvent of the as-prepared GdC/SiO 2 particle colloid solution with water, which provided diffusion of GdC into the silica shell and then formation of a hollow structure. The hollow particle colloid solution revealed good MRI properties. A relaxivity value for longitudinal relaxation time-weighted imaging was as high as 3.38 mM −1  · s −1 that attained 80% of that for a commercial Gd complex contrast agent.

Keywords

  • Hollow,
  • Core-shell,
  • Particle,
  • Gadolinium,
  • Homogeneous precipitation method,
  • Silica,
  • Sol-gel,
  • MRI
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