10.1007/s40097-017-0240-7

Green synthesis of polyhydroquinolines via MCR using Fe3O4/SiO2-OSO3H nanostructure catalyst and prediction of their pharmacological and biological activities by PASS

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  • Ali Maleki*1,
  • Ali R. Akbarzade1,
  • Ajmal R. Bhat2,
  1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR
  2. Department of Chemistry, RTM Nagpur University, Nagpur, 440033, IN
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Published in Issue 20-09-2017

How to Cite

Maleki, A., Akbarzade, A. R., & Bhat, A. R. (2017). Green synthesis of polyhydroquinolines via MCR using Fe3O4/SiO2-OSO3H nanostructure catalyst and prediction of their pharmacological and biological activities by PASS. Journal of Nanostructure in Chemistry, 7(4 (December 2017). https://doi.org/10.1007/s40097-017-0240-7
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Abstract

Abstract In this work, a library of diverse chemically and medicinally important heterocyclic polyhydroquinoline derivatives was efficiently prepared via a one-pot multicomponent reaction starting from various raw materials including aromatic aldehydes, dimedone or 1,3-cyclohexandione, ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of Fe 3 O 4 /SiO 2 -OSO 3 H as a sulfonated silica-based magnetic nanocatalyst in high yields. Main advantages of the present practical approach are ready availability of starting materials, non-toxicity, inexpensiveness, ease of workup procedure, diversity orientation synthesis and an eco-friendly nature of the reaction. The nanocatalyst was characterized by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM) images and energy-dispersive X-ray spectroscopy (EDX) spectra. The nanocatalyst was simply recovered using an external magnet and reused several times. Then, the pharmacological and biological activities of the products were theoretically examined by the prediction of activity spectra for substances (PASS) program. Graphical abstract

Keywords

  • Fe3O4/SiO2-OSO3H,
  • Nanocatalyst,
  • PASS program,
  • Biological activity,
  • Polyhydroquinolines
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References

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