10.1007/s40097-015-0178-6

Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats

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  • Arumugam Sengottaiyan1,
  • Adithan Aravinthan2,
  • Chinnapan Sudhakar1,
  • Kandasamy Selvam1,
  • Palanisamy Srinivasan1,
  • Muthusamy Govarthanan3,
  • Koildhasan Manoharan4,
  • Thangaswamy Selvankumar*1,
  1. Department of Biotechnology, Mahendra Arts and Science College (Autonomous), Kalippatti, Namakkal, Tamil Nadu, 637501, IN
  2. College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan, 570-752, KR
  3. Department of Biotechnology, Mahendra Arts and Science College (Autonomous), Kalippatti, Namakkal, Tamil Nadu, 637501, IN Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, 570-752, KR
  4. Raja Duraisingam Government Arts and Science College, Sivagangai, Tamil Nadu, IN
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Published in Issue 11-11-2015

How to Cite

Sengottaiyan, A., Aravinthan, A., Sudhakar, C., Selvam, K., Srinivasan, P., Govarthanan, M., Manoharan, K., & Selvankumar, T. (2015). Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats. Journal of Nanostructure in Chemistry, 6(1 (March 2016). https://doi.org/10.1007/s40097-015-0178-6
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Abstract

Abstract Solanum nigrum , a medicinal plant, traditionally used in treating diabetes mellitus. In this study, we used the leaf extract of the plant to synthesize silver nanoparticles (AgNPs), as a proposition to treat alloxan-induced diabetic rats. The phytosynthesised AgNPs were analyzed using UV–visible and Fourier transform infra-red spectroscopy for their functional groups. Transmission electron microscopy revealed that, the synthesized particles are found to be 4–25 nm in size. Monodispersed and spherical nature of synthesized AgNPs were shown by scanning electron microscope and the presence of Ag in the AgNPs was confirmed by energy dispersive spectrum. The phytosynthesised AgNPs were evaluated for its antidiabetic activity in alloxan-induced diabetic rats. AgNPs-treated diabetic rats found to be significantly improved the dyslipidemic condition as seen in the diabetic control. Furthermore, it also reduced the blood glucose level over the period of treatment. The improvement in body weight was also found to be evidence for S. nigrum extract-mediated AgNPs as a potential antidiabetic agent against alloxan-induced diabetic rats.

Keywords

  • Diabetes mellitus,
  • Solanum nigrum,
  • Silver nanoparticles,
  • Alloxan,
  • Animal model
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