10.1007/s40097-022-00494-1

Encapsulating MoS2-nanoflowers conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for photothermal inactivation of bacteria

  • Qilan Xu1,
  • Li Zhang1,
  • Yuhui Liu2,
  • Ling Cai3,
  • Liuzhu Zhou1,
  • Huijun Jiang4,
  • Jin Chen*5,
  1. Center for Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, CN
  2. State Key Laboratory of Nuclear Resources and Environment, School of Nuclear Science and Engineering, East China University of Technology, Nanchang, 330013, CN
  3. School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, CN
  4. School of Pharmacy, Nanjing Medical University, Nanjing, 211166, CN
  5. Center for Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, CN School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, CN School of Pharmacy, Nanjing Medical University, Nanjing, 211166, CN Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing, 211166, CN
Encapsulating MoS2-nanoflowers conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for photothermal inactivation of bacteria

Published in Issue 13-05-2022

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Xu, Q., Zhang, L., Liu, Y., Cai, L., Zhou, L., Jiang, H., & Chen, J. (2022). Encapsulating MoS2-nanoflowers conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for photothermal inactivation of bacteria. Journal of Nanostructure in Chemistry, 14(2 (April 2024). https://doi.org/10.1007/s40097-022-00494-1
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Abstract

Abstract The bacterial inactivation using near-infrared (NIR) light irradiation with spatiotemporal control is advantageous to deal with the emerging microbial infection and the drug resistance in the environment and health-care facilities. Here, nanoflower-like MoS 2 prepared by electrolysis synthesis was functionalized with α-lipoic acid and chitosan oligosaccharide (MoS 2 -LA-COS) resulting in a highly biocompatible, well dispersive, and NIR photo-responsive composite. The produced nanocomposite of MoS 2 -LA-COS retained the nanoflower-like morphological feature, of which the hexagonal structure (2H phase) was similar with that of MoS 2 according to the X-ray diffraction measurement. Moreover, the produced MoS 2 -LA-COS was efficiently loaded into the electrospun nanofiber membranes (ENFs) endowing the fibrous scaffold with outstanding photothermal performance. The antibacterial studies indicated a superior bactericidal effect of the formed membranes under NIR irradiation towards the inactivation of model G − Staphylococcus aureus and G + Escherichia coli strains, which was originated from the uniform distribution of MoS 2 -LA-COS on the fibrous scaffold. The produced MoS 2 -LA-COS nanofibrous membranes of good water vapor transmission rate and improved photothermal performance possess enormous potential for the development as well as the disposal of personal protective equipment such as medical masks. Graphical abstract

Keywords

  • MoS2,
  • Near infrared,
  • Antibacterial,
  • Electrospun nanofiber membranes,
  • Photothermal therapy,
  • Chitosan oligosaccharide

References

  1. Huemer et al. (2020) Antibiotic resistance and persistence-Implications for human health and treatment perspectives https://doi.org/10.15252/embr.202051034
  2. McEwen and Collignon (2018) Antimicrobial resistance: a one health perspective https://doi.org/10.1128/microbiolspec.ARBA-0009-2017
  3. Holmes et al. (2016) Understanding the mechanisms and drivers of antimicrobial resistance (pp. 176-187) https://doi.org/10.1016/S0140-6736(15)00473-0
  4. An et al. (2021) Plasmonic nano-antimicrobials: properties, mechanisms and applications in microbe inactivation and sensing (pp. 3374-3411) https://doi.org/10.1039/D0NR08353D
  5. Chen et al. (2020) Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment (pp. 251-262) https://doi.org/10.1016/j.jconrel.2020.08.055
  6. Ashrafi et al. (2020) Antimicrobial effect of chitosan–silver–copper nanocomposite on candida albicans (pp. 87-95) https://doi.org/10.1007/s40097-020-00331-3
  7. González-Ballesteros et al. (2020) Synthesis of silver and gold nanoparticles by sargassum muticum biomolecules and evaluation of their antioxidant activity and antibacterial properties (pp. 317-330) https://doi.org/10.1007/s40097-020-00352-y
  8. Sun et al. (2019) Synergistic photodynamic and photothermal antibacterial nanocomposite membrane triggered by single NIR light source (pp. 26581-26589) https://doi.org/10.1021/acsami.9b07037
  9. Li et al. (2022) Injectable stretchable self-healing dual dynamic network hydrogel as adhesive anti-oxidant wound dressing for photothermal clearance of bacteria and promoting wound healing of MRSA infected motion wounds https://doi.org/10.1016/j.cej.2021.132039
  10. Tan et al. (2018) Rapid biofilm eradication on bone implants using red phosphorus and near-infrared light https://doi.org/10.1002/adma.201801808
  11. Xu et al. (2021) Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds https://doi.org/10.1186/s12951-021-01152-4
  12. Wei and Yu (2019) Responsive and synergistic antibacterial coatings: fighting against bacteria in a smart and effective way https://doi.org/10.1002/adhm.201801381
  13. Xie et al. (2018) Tuning the bandgap of photo-sensitive polydopamine/Ag(3)PO(4)/graphene oxide coating for rapid, noninvasive disinfection of implants (pp. 724-738) https://doi.org/10.1021/acscentsci.8b00177
  14. Aksoy et al. (2020) Photothermal antibacterial and antibiofilm activity of black phosphorus/gold nanocomposites against pathogenic bacteria (pp. 26822-26831) https://doi.org/10.1021/acsami.0c02524
  15. Priyadarsini et al. (2018) Graphene and graphene oxide as nanomaterials for medicine and biology application (pp. 123-137) https://doi.org/10.1007/s40097-018-0265-6
  16. Zhong et al. (2020) Reusable and recyclable graphene masks with outstanding superhydrophobic and photothermal performances (pp. 6213-6221) https://doi.org/10.1021/acsnano.0c02250
  17. Yougbaré et al. (2020) Nanomaterials for the photothermal killing of bacteria https://doi.org/10.3390/nano10061123
  18. Kennedy et al. (2005) An investigation of the thermal inactivation of staphylococcus aureus and the potential for increased thermotolerance as a result of chilled storage (pp. 1229-1235) https://doi.org/10.1111/j.1365-2672.2005.02697.x
  19. Li et al. (2019) Highly effective and noninvasive near-infrared eradication of a staphylococcus aureus biofilm on implants by a photoresponsive coating within 20 min https://doi.org/10.1002/advs.201900599
  20. Hao et al. (2017) In vivo long-term biodistribution, excretion, and toxicology of PEGylated transition-metal dichalcogenides MS (M = Mo, W, Ti) https://doi.org/10.1002/advs.201600160
  21. Oudeng et al. (2018) One-step in situ detection of miRNA-21 expression in single cancer cells based on biofunctionalized MoS2 nanosheets (pp. 350-360) https://doi.org/10.1021/acsami.7b18102
  22. Shi et al. (2020) Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment (pp. 5793-5807) https://doi.org/10.1039/D0TB01018A
  23. Cao et al. (2017) An efficient and benign antimicrobial depot based on silver-infused MoS(2) (pp. 4651-4659) https://doi.org/10.1021/acsnano.7b00343
  24. Wang et al. (2015) Differences in the toxicological potential of 2D versus aggregated molybdenum disulfide in the Lung (pp. 5079-5087) https://doi.org/10.1002/smll.201500906
  25. Yin et al. (2016) Functionalized nano-MoS(2) with peroxidase catalytic and near-Infrared photothermal activities for safe and synergetic wound antibacterial applications (pp. 11000-11011) https://doi.org/10.1021/acsnano.6b05810
  26. Yuwen et al. (2021) Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal/photodynamic therapy of methicillin-resistant infections (pp. 4484-4495) https://doi.org/10.1039/D1BM00406A
  27. Ma et al. (2021) A smart nanoplatform with photothermal antibacterial capability and antioxidant activity for chronic wound healing https://doi.org/10.1002/adhm.202100033
  28. Chou et al. (2013) Chemically exfoliated MoS2 as near-infrared photothermal agents (pp. 4160-4164) https://doi.org/10.1002/anie.201209229
  29. Xu et al. (2021) A green electrolysis of silver-decorated MoS2 nanocomposite with an enhanced antibacterial effect and low cytotoxicity (pp. 3460-3469) https://doi.org/10.1039/D1NA00100K
  30. Yang et al. (2020) Electrochemical generation of liquid and solid sulfur on two-dimensional layered materials with distinct areal capacities (pp. 231-237) https://doi.org/10.1038/s41565-019-0624-6
  31. Xu et al. (2020) Electrochemical formation of distinct nanostructured MoS2 with altered antibacterial activity https://doi.org/10.1016/j.matlet.2020.127809
  32. Croisier et al. (2015) Chitosan-coated electrospun nanofibers with antibacterial activity (pp. 3508-3517) https://doi.org/10.1039/C5TB00158G
  33. Kurtz and Schiffman (2018) Current and emerging approaches to engineer antibacterial and antifouling electrospun nanofibers https://doi.org/10.3390/ma11071059
  34. He et al. (2020) Anti-oxidant electroactive and antibacterial nanofibrous wound dressings based on poly(ε-caprolactone)/quaternized chitosan-graft-polyaniline for full-thickness skin wound healing https://doi.org/10.1016/j.cej.2019.123464
  35. Zhao et al. (2021) Injectable dry cryogels with excellent blood-sucking expansion and blood clotting to cease hemorrhage for lethal deep-wounds, coagulopathy and tissue regeneration https://doi.org/10.1016/j.cej.2020.126329
  36. Sepahi et al. (2020) Introducing electrospun polylactic acid incorporating etched halloysite nanotubes as a new nanofibrous web for controlled release of amoxicillin (pp. 245-258) https://doi.org/10.1007/s40097-020-00362-w
  37. Wang et al. (2020) Highly efficient transparent air filter prepared by collecting-electrode-free bipolar electrospinning apparatus https://doi.org/10.1016/j.jhazmat.2019.121535
  38. Buivydiene et al. (2019) Formation and characterisation of air filter material printed by melt electrospinning (pp. 48-63) https://doi.org/10.1016/j.jaerosci.2019.03.003
  39. Zhu et al. (2019) Bio-based and photocrosslinked electrospun antibacterial nanofibrous membranes for air filtration (pp. 55-62) https://doi.org/10.1016/j.carbpol.2018.09.075
  40. Kim et al. (2004) Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds (pp. 47-56) https://doi.org/10.1016/j.jconrel.2004.04.009
  41. Gizaw et al. (2018) Electrospun fibers as a dressing material for drug and biological agent delivery in wound healing applications
  42. Zhang et al. (2019) Silver-infused porphyrinic metal-organic framework: surface-adaptive, on-demand nanoplatform for synergistic bacteria killing and wound disinfection https://doi.org/10.1002/adfm.201808594
  43. Stanislav Presolski (2016) Covalent functionalization of MoS2 (pp. 140-145) https://doi.org/10.1016/j.mattod.2015.08.019
  44. Liu et al. (2014) Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer (pp. 3433-3440) https://doi.org/10.1002/adma.201305256
  45. Zhang et al. (2021) Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing https://doi.org/10.1016/j.carbpol.2021.118100
  46. Yue et al. (2020) Cinnamyl alcohol modified chitosan oligosaccharide for enhancing antimicrobial activity https://doi.org/10.1016/j.foodchem.2019.125513
  47. Yan et al. (2015) Polydopamine-coated electrospun poly(vinyl alcohol)/poly(acrylic acid) membranes as efficient dye adsorbent with good recyclability (pp. 730-739) https://doi.org/10.1016/j.jhazmat.2014.10.040
  48. Liu et al. (2018) Electrochemical synthesis and tribological properties of flower-like and sheet-like MoS2 in LiCl KCl (NH4)6Mo7O24KSCN melt (pp. 252-260) https://doi.org/10.1016/j.electacta.2018.03.015
  49. Xu et al. (2017) Integration of IR-808 sensitized upconversion nanostructure and MoS2 nanosheet for 808 nm NIR light triggered phototherapy and bioimaging https://doi.org/10.1002/smll.201701841
  50. Franco et al. (2012) On stabilization of PVPA/PVA electrospun nanofiber membrane and its effect on material properties and biocompatibility https://doi.org/10.1155/2012/393042
  51. Liu et al. (2020) Enhanced antimicrobial activity and pH-responsive sustained release of chitosan/poly (vinyl alcohol)/graphene oxide nanofibrous membrane loading with allicin (pp. 1405-1413) https://doi.org/10.1016/j.ijbiomac.2020.08.051
  52. Chang et al. (2016) Targeted synthesis of 2H- and 1T-phase MoS2 monolayers for catalytic hydrogen evolution (pp. 10033-10041) https://doi.org/10.1002/adma.201603765
  53. Zhang et al. (2016) The surface grafting of graphene oxide with poly(ethylene glycol) as a reinforcement for poly(lactic acid) nanocomposite scaffolds for potential tissue engineering applications (pp. 403-413) https://doi.org/10.1016/j.jmbbm.2015.08.043
  54. Wang et al. (2020) Boron-modified defect-rich molybdenum disulfide nanosheets: reducing nonspecific adsorption and promoting a high capacity for isolation of immunoglobulin G (pp. 43273-43280) https://doi.org/10.1021/acsami.0c12171
  55. Lawrie et al. (2007) Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS (pp. 2533-2541) https://doi.org/10.1021/bm070014y
  56. Liu et al. (2014) Solution blowing of chitosan/PVA hydrogel nanofiber mats (pp. 1116-1121) https://doi.org/10.1016/j.carbpol.2013.10.056
  57. Teng et al. (2016) MoS2 nanosheets vertically grown on graphene sheets for lithium-ion battery anodes (pp. 8526-8535) https://doi.org/10.1021/acsnano.6b03683
  58. Merki et al. (2011) Amorphous molybdenum sulfide films as catalysts for electrochemical hydrogen production in water (pp. 1262-1267) https://doi.org/10.1039/C1SC00117E
  59. Tang et al. (2018) Acidity/reducibility dual-responsive hollow mesoporous organosilica nanoplatforms for tumor-specific self-assembly and synergistic therapy (pp. 12269-12283) https://doi.org/10.1021/acsnano.8b06058
  60. Yin et al. (2014) Multifunctional upconverting nanoparticles for near-infrared triggered and synergistic antibacterial resistance therapy (pp. 10488-10490) https://doi.org/10.1039/C4CC04584J
  61. Yong et al. (2017) Polyoxometalate-based radiosensitization platform for treating hypoxic tumors by attenuating radioresistance and enhancing radiation response (pp. 7164-7176) https://doi.org/10.1021/acsnano.7b03037
  62. Bhardwaj and Kundu (2010) Electrospinning: a fascinating fiber fabrication technique (pp. 325-347) https://doi.org/10.1016/j.biotechadv.2010.01.004
  63. Cheng, F., Gao, J., Wang, L., Hu, X.: Composite chitosan/poly (ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs. J. Appl. Polym. Sci.
  64. 132
  65. (2015).
  66. https://doi.org/10.1002/APP.42060
  67. Jannesari et al. (2011) Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs (pp. 993-1003)
  68. Li et al. (2021) Photocatalytic rejuvenation enabled self-sanitizing, reusable, and biodegradable masks against COVID-19 (pp. 11992-12005) https://doi.org/10.1021/acsnano.1c03249
  69. Huang et al. (2020) Self-Reporting and photothermally enhanced rapid bacterial killing on a laser-induced graphene mask (pp. 12045-12053) https://doi.org/10.1021/acsnano.0c05330
  70. Lin et al. (2020) Superhydrophobic, photo-sterilize, and reusable mask based on graphene nanosheet-embedded carbon (GNEC) film (pp. 1110-1115) https://doi.org/10.1007/s12274-020-3158-1