10.1007/s40097-021-00450-5

Synthesis of benzothiazole and benzimidazole derivatives via an eco-friendly method using piperazine immobilized on nano-ZnO-sulfuric acid as a powerful catalyst

  • Maryam Mousapour1,
  • Farhad Shirini*1,
  1. Department of Chemistry, College of Sciences, University of Guilan, Rasht, 41335-19141, IR

Published in Issue 14-10-2021

How to Cite

Mousapour, M., & Shirini, F. (2021). Synthesis of benzothiazole and benzimidazole derivatives via an eco-friendly method using piperazine immobilized on nano-ZnO-sulfuric acid as a powerful catalyst. Journal of Nanostructure in Chemistry, 13(4 (August 2023). https://doi.org/10.1007/s40097-021-00450-5
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Abstract

Abstract In this research, the synthesis of piperazine immobilized on nano-ZnO-sulfuric acid (PINZS) as a new piperazine-based nano-reagent is reported. After identification of PINZS using different techniques including XRD (X-ray powder diffraction), TGA (thermogravimetric analysis), FT-IR (Fourier transform infrared spectroscopy), FESEM (field emission scanning electron microscopy), and EDX (energy-dispersive X-ray) analysis, this reagent is efficiently used for the synthesis of 1-(benzothiazolylamino) phenylmethyl-2-naphthols and pyrimido[1, 2-a]benzimidazoles via a domino Knoevenagel/Michael sequence which identified acceptable reaction times (7–45 min.), great yields (up to 98%) and ease of the preparation, separation, and recovery of PINZS (for three times) as the most important features of this protocol. Graphic abstract Use of PINZS in the synthesis of some important heterocycles.

Keywords

  • ZnO NPs,
  • Piperazine,
  • Immobilized ionic liquids,
  • Multi-component reactions,
  • Pyrimido[1,2-a]benzimidazole,
  • 1-(Benzothiazolylamino) phenylmethyl-2-naphthol

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