10.1007/s40097-022-00504-2

Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions

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  • Hardeep Singh Tuli1,
  • Ruchira Joshi2,
  • Ginpreet Kaur2,
  • Vivek Kumar Garg3,
  • Katrin Sak4,
  • Mehmet Varol5,
  • Jagjit Kaur6,
  • Sulaiman Ali Alharbi7,
  • Tahani Awad Alahmadi8,
  • Diwakar Aggarwal1,
  • Kuldeep Dhama9,
  • Vivek Sheel Jaswal10,
  • Sonam Mittal11,
  • Gautam Sethi*12,
  1. Department of Biotechnology, Maharishi Markandeshwar (Deemed to Be University), Ambala, Haryana, 133207, IN
  2. Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s, NMIMS, Mumbai, Maharashtra, 400056, IN
  3. Department of Medical Laboratory Technology, University Institute of Applied Health Sciences, Chandigarh University, Mohali, Punjab, 140413, IN
  4. NGO Praeventio, Tartu, 50407, EE
  5. Department of Molecular Biology and Genetics, Faculty of Science, Mugla Sitki Kocman University, Mugla, 48000, TR
  6. ARC Centre of Excellence in Nanoscale Biophotonics (CNBP), Graduate School of Biomedical Engineering, Faculty of Engineering, The University of New South Wales, Sydney, 2052, AU
  7. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, SA
  8. Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, 11461, SA
  9. Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, 243122, IN
  10. Department of Chemistry and Chemical Sciences, School of Physical & Material Sciences, Central University of Himachal Pradesh, Dharamshala, Himachal Pradesh, 176202, IN
  11. School of Biotechnology, Jawaharlal Nehru University, New Delhi, IN
  12. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, SG

Published in Issue 15-06-2022

How to Cite

Tuli, H. S., Joshi, R., Kaur, G., Garg, V. K., Sak, K., Varol, M., Kaur, J., Alharbi, S. A., Alahmadi, T. A., Aggarwal, D., Dhama, K., Jaswal, V. S., Mittal, S., & Sethi, G. (2022). Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions. Journal of Nanostructure in Chemistry, 13(3 (June 2023). https://doi.org/10.1007/s40097-022-00504-2
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Abstract

Abstract Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to diagnose and treat cancer. Evidence suggested that metal NPs can modulate the expression of various intracellular and extra-cellular signaling molecules in the tumor microenvironment. Metal nanoparticles possess anti-cancer activities via apoptosis and cell cycle arrest. In addition, metal NPs inhibit tumor angiogenesis, metastasis and inflammation to stop cancer proliferation. Synergistic applications of metal NPs with existing anti-cancer agents showed improvement in their bioactivity and bioavailability. This review explores the synthetic approaches, pharmacokinetics, and the cellular and molecular interactions of metal NPs in cancer. Graphical abstract

Keywords

  • Nanoparticles,
  • Apoptosis,
  • Anti-angiogenesis,
  • Anti-metastasis,
  • Anti-inflammation,
  • Synergistic effect

References

  1. Ferlay et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 (pp. 2893-2917) https://doi.org/10.1002/ijc.25516
  2. Kashyap et al. (2021) Oncogenic and tumor suppressive components of the cell cycle in breast cancer progression and prognosis (pp. 1-28) https://doi.org/10.3390/pharmaceutics13040569
  3. Kashyap et al. (2019) Fisetin and quercetin: promising flavonoids with chemopreventive potential (pp. 1-22) https://doi.org/10.3390/biom9050174
  4. Ferlay et al. (2021) Cancer statistics for the year 2020: an overview (pp. 778-789) https://doi.org/10.1002/ijc.33588
  5. Kashyap, D., Sharma, A., Tuli, H.S., Sak, K., Garg, V.K., Buttar, H.S., Setzer, W.N., Sethi, G.: Apigenin: a natural bioactive flavone-type molecule with promising therapeutic function (2018)
  6. Yadav, P., Jaswal, V., Sharma, A., Kashyap, D., Tuli, H.S., Garg, V.K., Das, S.K., Srinivas, R.: Celastrol as a pentacyclic triterpenoid with chemopreventive properties,
  7. https://pubmed.ncbi.nlm.nih.gov/29882724/
  8. (2018)
  9. Kashyap et al. (2019) Role of reactive oxygen species in cancer progression (pp. 79-86) https://doi.org/10.1007/s40495-019-00171-y
  10. Sung et al. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (pp. 209-249) https://doi.org/10.3322/caac.21660
  11. Kashyap, D., Garg, V.K., Goel, N.: Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis. Elsevier Inc. (2021)
  12. Kashyap et al. (2021) Natural product-based nanoformulations for cancer therapy: opportunities and challenges (pp. 5-23) https://doi.org/10.1016/j.semcancer.2019.08.014
  13. Kashyap et al. (2016) Reactive oxygen species (ROS ): an activator of apoptosis and autophagy in cancer (pp. 256-264)
  14. Kashyap, D., Tuli, H.S., Garg, V.K., Bhatnagar, S., Sharma, A.K.: Ursolic acid and quercetin: promising anticancer phytochemicals with antimetastatic and antiangiogenic potential. 1–7 (2017).
  15. Manu et al. (2014) Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products (pp. 267-276) https://doi.org/10.1007/s00109-013-1095-0
  16. Kirtonia et al. (2021) Repurposing of drugs: an attractive pharmacological strategy for cancer therapeutics (pp. 258-278) https://doi.org/10.1016/j.semcancer.2020.04.006
  17. Valladares et al. (2021) Adjuvant treatment in lung cancer
  18. Román-Jobacho et al. (2021) Oligometastatic non-small cell lung cancer: current management 7(3)
  19. Luna et al. (2021) Recent advances in early stage lung cancer 7(2)
  20. Lu et al. (2021) Research progress in immunotherapy of advanced non-small cell lung cancer (pp. 58-64) https://doi.org/10.24294/ti.v5.i2.1.1367
  21. Guo et al. (2021) Studies on the proliferation inhibition effects of tua from Actinidia chinensis radix on lung cancer xenografts in nude mice and its preliminary mechanism (pp. 14-23) https://doi.org/10.24294/ti.v5.i2.1.1371
  22. Conde et al. (2012) Noble metal nanoparticles applications in cancer (pp. 1-12) https://doi.org/10.1155/2012/751075
  23. Tuli et al. (2021) Anti-inflammatory and anticancer properties of birch bark-derived betulin: recent developments https://doi.org/10.3390/plants10122663
  24. Tuli et al. (2021) Gallic acid: a dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets (pp. 499-514) https://doi.org/10.2174/1871520621666211119085834
  25. Singh and Goel (2020) Yogita: integrative analysis of multi-genomic data for kidney renal cell carcinoma (pp. 12-23) https://doi.org/10.1007/s12539-019-00345-8
  26. Zhang et al. (2016) Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model (pp. 575-589) https://doi.org/10.1089/ars.2015.6418
  27. Kwang et al. (2008) Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway (pp. 1733-1740) https://doi.org/10.1002/ijc.23745
  28. Rai et al. (2016) Strategic role of selected noble metal nanoparticles in medicine (pp. 696-719)
  29. Nasery et al. (2020) Curcumin delivery mediated by bio-based nanoparticles: a review https://doi.org/10.3390/molecules25030689
  30. Yan et al. (2020) Chiral protein supraparticles for tumor suppression and synergistic immunotherapy: an enabling strategy for bioactive supramolecular chirality construction (pp. 5844-5852) https://doi.org/10.1021/acs.nanolett.0c01757
  31. Guo et al. (2017) Experimental evaluation of the lubrication performance of mixtures of castor oil with other vegetable oils in MQL grinding of nickel-based alloy (pp. 1060-1076) https://doi.org/10.1016/j.jclepro.2016.10.073
  32. Zhang et al. (2018) Experimental assessment of an environmentally friendly grinding process using nanofluid minimum quantity lubrication with cryogenic air (pp. 236-248) https://doi.org/10.1016/j.jclepro.2018.05.009
  33. Kuchur et al. (2020) Metal-derived nanoparticles in tumor theranostics: potential and limitations https://doi.org/10.1016/j.jinorgbio.2020.111117
  34. Li et al. (2022) Metal-based nano-vaccines for cancer immunotherapy https://doi.org/10.1016/j.ccr.2021.214345
  35. Zou et al. (2019) Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA (pp. 205-218) https://doi.org/10.1261/rna.069112.118
  36. Zhao et al. (2022) Recent advances in the development of noble metal NPs for cancer therapy https://doi.org/10.1155/2022/2444516
  37. Shariatzadeh et al. (2022) Metallic nanoparticles for the modulation of tumor microenvironment: a new horizon https://doi.org/10.3389/fbioe.2022.847433
  38. Subhan and Muzibur Rahman (2022) Recent development in metallic nanoparticles for breast cancer therapy and diagnosis https://doi.org/10.1002/tcr.202100331
  39. Khursheed et al. (2022) Biomedical applications of metallic nanoparticles in cancer: current status and future perspectives https://doi.org/10.1016/j.biopha.2022.112951
  40. Xu et al. (2022) Metal nanoparticles as a promising technology in targeted cancer treatment (pp. 664-678) https://doi.org/10.1080/10717544.2022.2039804
  41. Evans et al. (2018) Metallic nanoparticles for cancer immunotherapy (pp. 673-685) https://doi.org/10.1016/j.mattod.2017.11.022
  42. Tinajero-Díaz et al. (2021) Green metallic nanoparticles for cancer therapy: evaluation models and cancer applications https://doi.org/10.3390/pharmaceutics13101719
  43. Desoize (2004) Metals and metal compounds in cancer treatment (pp. 1529-1544)
  44. Chen et al. (2022) Non-invasive discrimination of multiple myeloma using label-free serum surface-enhanced Raman scattering spectroscopy in combination with multivariate analysis https://doi.org/10.1016/j.aca.2021.339296
  45. Păduraru et al. (2022) Recent developments in metallic nanomaterials for cancer therapy. Diagnosing and imaging applications https://doi.org/10.3390/pharmaceutics14020435
  46. Niculescu and Grumezescu (2022) Novel tumor-targeting nanoparticles for cancer treatment—a review https://doi.org/10.3390/ijms23095253
  47. Baig et al. (2021) Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges (pp. 1821-1871) https://doi.org/10.1039/D0MA00807A
  48. Prabakaran, S., Rajan, M.: Biosynthesis of nanoparticles and their roles in numerous areas. In: Comprehensive Analytical Chemistry. pp. 1–47. Elsevier (2021)
  49. Yilmaz, E., Soylak, M.: Functionalized nanomaterials for sample preparation methods. In: Handbook of Nanomaterials in Analytical Chemistry: Modern Trends in Analysis. pp. 375–413. Elsevier (2019)
  50. Chen et al. (2021) Corynoxine protects dopaminergic neurons through inducing autophagy and diminishing neuroinflammation in rotenone-induced animal models of Parkinson’s disease https://doi.org/10.3389/fphar.2021.642900
  51. Jin et al. (2022) Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age-related macular degeneration (pp. e512-e520) https://doi.org/10.1111/aos.14928
  52. Sun et al. (2021) Chemical vapour deposition 11(1) (pp. 1-20)
  53. Raizada et al. (2020) Engineering nanostructures of CuO-based photocatalysts for water treatment: current progress and future challenges (pp. 8424-8457) https://doi.org/10.1016/j.arabjc.2020.06.031
  54. El-Deeb et al. (2022) Arthrospira platensis-mediated green biosynthesis of silver nano-particles as breast cancer controlling agent. in vitro and in vivo safety approaches (pp. 2183-2203) https://doi.org/10.1007/s12010-021-03751-1
  55. Ko et al. (2022) Pharmacological role of functionalized gold nanoparticles in disease applications https://doi.org/10.3390/molecules27051551
  56. Gao et al. (2021) Grindability of carbon fiber reinforced polymer using CNT biological lubricant (pp. 1-14) https://doi.org/10.1038/s41598-021-02071-y
  57. Li et al. (2016) Grinding temperature and energy ratio coefficient in MQL grinding of high-temperature nickel-base alloy by using different vegetable oils as base oil (pp. 1084-1095) https://doi.org/10.1016/j.cja.2015.10.012
  58. Dhand et al. (2015) Methods and strategies for the synthesis of diverse nanoparticles and their applications: a comprehensive overview (pp. 105003-105037) https://doi.org/10.1039/C5RA19388E
  59. Liu et al. (2021) Cryogenic minimum quantity lubrication machining: from mechanism to application 16(4) (pp. 649-697) https://doi.org/10.1007/s11465-021-0654-2
  60. Xin et al. (2021) Minimum quantity lubrication machining of aeronautical materials using carbon group nanolubricant: from mechanisms to application https://doi.org/10.1016/j.cja.2021.08.011
  61. Vaseghi et al. (2018) Green methods for the synthesis of metal nanoparticles using biogenic reducing agents: a review (pp. 529-559) https://doi.org/10.1515/revce-2017-0005
  62. Abid et al. (2022) Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: a review https://doi.org/10.1016/j.cis.2021.102597
  63. Almeida et al. (2020) Red ruby glass from gold nanoparticles obtained by LASiS—a new approach https://doi.org/10.1016/j.jnoncrysol.2020.119987
  64. Yang et al. (2018) The roles of morphology on the relaxation rates of magnetic nanoparticles (pp. 4605-4614) https://doi.org/10.1021/acsnano.8b01048
  65. Liu and Corma (2018) Metal catalysts for heterogeneous catalysis: from single atoms to nanoclusters and nanoparticles (pp. 4981-5079) https://doi.org/10.1021/acs.chemrev.7b00776
  66. Astruc (2020) Introduction: nanoparticles in catalysis (pp. 461-463) https://doi.org/10.1021/acs.chemrev.8b00696
  67. Behzadi et al. (2017) Cellular uptake of nanoparticles: journey inside the cell (pp. 4218-4244) https://doi.org/10.1039/C6CS00636A
  68. Romberg et al. (2008) Sheddable coatings for long-circulating nanoparticles (pp. 55-71) https://doi.org/10.1007/s11095-007-9348-7
  69. Gwon et al. (2022) Biocompatible core–shell-structured Si-based NiO nanoflowers and their anticancer activity https://doi.org/10.3390/pharmaceutics14020268
  70. Lin et al. (2015) Pharmacokinetics of metallic nanoparticles (pp. 189-217) https://doi.org/10.1002/wnan.1304
  71. Park et al. (2011) Bioavailability and toxicokinetics of citrate-coated silver nanoparticles in rats (pp. 153-158) https://doi.org/10.1007/s12272-011-0118-z
  72. Mathur et al. (2018) Pharmaceutical aspects of silver nanoparticles (pp. 115-126) https://doi.org/10.1080/21691401.2017.1414825
  73. Samberg et al. (2010) Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro (pp. 407-413) https://doi.org/10.1289/ehp.0901398
  74. Larese et al. (2009) Human skin penetration of silver nanoparticles through intact and damaged skin (pp. 33-37) https://doi.org/10.1016/j.tox.2008.09.025
  75. Lankveld et al. (2010) The kinetics of the tissue distribution of silver nanoparticles of different sizes (pp. 8350-8361) https://doi.org/10.1016/j.biomaterials.2010.07.045
  76. Dziendzikowska et al. (2012) Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats (pp. 920-928) https://doi.org/10.1002/jat.2758
  77. Kim et al. (2008) Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats (pp. 575-583) https://doi.org/10.1080/08958370701874663
  78. Loeschner et al. (2011) Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate https://doi.org/10.1186/1743-8977-8-18
  79. Park et al. (2010) Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles (pp. 162-168) https://doi.org/10.1016/j.etap.2010.05.004
  80. Kim et al. (2010) Subchronic oral toxicity of silver nanoparticles https://doi.org/10.1186/1743-8977-7-20
  81. Tang et al. (2008) Influence of silver nanoparticles on neurons and blood-brain barrier via subcutaneous injection in rats (pp. 502-504) https://doi.org/10.1016/j.apsusc.2008.06.058
  82. Van Der Zande et al. (2012) Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure (pp. 7427-7442) https://doi.org/10.1021/nn302649p
  83. Kim et al. (2010) Subchronic oral toxicity of silver nanoparticles https://doi.org/10.1186/1743-8977-7-20
  84. Liu et al. (2012) Chemical transformations of nanosilver in biological environments (pp. 9887-9899) https://doi.org/10.1021/nn303449n
  85. Lee et al. (2013) Serum kinetics, distribution and excretion of silver in rabbits following 28 days after a single intravenous injection of silver nanoparticles (pp. 1120-1130) https://doi.org/10.3109/17435390.2012.710660
  86. Yang et al. (2019) Predictive model for minimum chip thickness and size effect in single diamond grain grinding of zirconia ceramics under different lubricating conditions (pp. 14908-14920) https://doi.org/10.1016/j.ceramint.2019.04.226
  87. Libutti et al. (2010) Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine (pp. 6139-6149) https://doi.org/10.1158/1078-0432.CCR-10-0978
  88. NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery—Full Text View—ClinicalTrials.gov,
  89. https://clinicaltrials.gov/ct2/show/NCT03020017
  90. ClinicalTrials.gov: National Library of Medicine (US): Pilot Study of AuroLase(tm) Therapy in Refractory and/or Recurrent Tumors of the Head and Neck - Full Text View - ClinicalTrials.gov,
  91. https://clinicaltrials.gov/ct2/show/NCT00848042
  92. Magnetic Nanoparticle Thermoablation-Retention and Maintenance in the Prostate:A Phase 0 Study in Men - Full Text View - ClinicalTrials.gov,
  93. https://clinicaltrials.gov/ct2/show/NCT02033447
  94. .
  95. Schleh et al. (2012) Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration (pp. 36-46) https://doi.org/10.3109/17435390.2011.552811
  96. Janer et al. (2014) Cell uptake and oral absorption of titanium dioxide nanoparticles (pp. 103-110) https://doi.org/10.1016/j.toxlet.2014.04.014
  97. Cho et al. (2009) Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles (pp. 16-24) https://doi.org/10.1016/j.taap.2008.12.023
  98. Sonavane et al. (2008) In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size (pp. 1-10) https://doi.org/10.1016/j.colsurfb.2008.02.013
  99. De Jong et al. (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration (pp. 1912-1919) https://doi.org/10.1016/j.biomaterials.2007.12.037
  100. Takeda et al. (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems (pp. 95-102) https://doi.org/10.1248/jhs.55.95
  101. Bourrinet et al. (2006) Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent (pp. 313-324) https://doi.org/10.1097/01.rli.0000197669.80475.dd
  102. Liu et al. (2015) Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects (pp. 8-14) https://doi.org/10.1016/j.canlet.2015.03.019
  103. Patel et al. (2016) Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases (pp. 100-115) https://doi.org/10.1016/j.semcancer.2016.03.002
  104. Kirtonia et al. (2020) The multifaceted role of reactive oxygen species in tumorigenesis (pp. 4459-4483) https://doi.org/10.1007/s00018-020-03536-5
  105. Kim et al. (2018) Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model (pp. 123-141) https://doi.org/10.1016/j.canlet.2018.05.038
  106. Manu et al. (2012) First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway (pp. 2220-2229) https://doi.org/10.1158/1078-0432.CCR-11-2470
  107. Manu et al. (2015) Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer (pp. 28-36) https://doi.org/10.1016/j.canlet.2015.03.033
  108. Ahmadian et al. (2018) Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line (pp. 465-471) https://doi.org/10.1016/j.msec.2018.08.027
  109. Acharya et al. (2021) Apoptotic effect and anticancer activity of biosynthesized silver nanoparticles from marine algae Chaetomorpha linum extract against human colon cancer Cell HCT-116 (pp. 1812-1822) https://doi.org/10.1007/s12011-020-02304-7
  110. Quan et al. (2021) Silver nanoparticles induce apoptosis via NOX4-derived mitochondrial reactive oxygen species and endoplasmic reticulum stress in colorectal cancer cells (pp. 1357-1375) https://doi.org/10.2217/nnm-2021-0098
  111. Akter et al. (2021) Green synthesized silver nanoparticles-mediated cytotoxic effect in colorectal cancer cells: NF-κB signal induced apoptosis through autophagy (pp. 3272-3286) https://doi.org/10.1007/s12011-020-02463-7
  112. Mohd Faheem et al. (2022) Induction of p53 mediated mitochondrial apoptosis and cell cycle arrest in human breast cancer cells by plant mediated synthesis of silver nanoparticles from Bergenia ligulata (Whole plant) https://doi.org/10.1016/j.ijpharm.2022.121710
  113. Alamer et al. (2021) Bismuth oxide nanoparticles induce oxidative stress and apoptosis in human breast cancer cells (pp. 7379-7389) https://doi.org/10.1007/s11356-020-10913-x
  114. Khan et al. (2021) Zinc oxide nanoparticle induces apoptosis in human epidermoid carcinoma cells through reactive oxygen species and DNA degradation (pp. 2172-2181) https://doi.org/10.1007/s12011-020-02323-4
  115. Bai et al. (2017) Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells (pp. 6521-6535) https://doi.org/10.2147/IJN.S140071
  116. Wang et al. (2019) Synthesis of Zinc oxide nanoparticles from Marsdenia tenacissima inhibits the cell proliferation and induces apoptosis in laryngeal cancer cells (Hep-2) https://doi.org/10.1016/j.jphotobiol.2019.111624
  117. Akhtar et al. (2012) Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species (pp. 845-857)
  118. Mahdizadeh et al. (2019) Green synthesized-zinc oxide nanoparticles, the strong apoptosis inducer as an exclusive antitumor agent in murine breast tumor model and human breast cancer cell lines (MCF7) (pp. 17984-17993) https://doi.org/10.1002/jcb.29065
  119. Li et al. (2020) Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells
  120. Shi et al. (2010) Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway (pp. 21-27) https://doi.org/10.1016/j.toxlet.2010.03.014
  121. Cheng et al. (2013) Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways (pp. 1082-1088) https://doi.org/10.1016/j.tiv.2013.02.005
  122. Al-zharani et al. (2021) Antitumor effect of copper nanoparticles on human breast and colon malignancies (pp. 1587-1595) https://doi.org/10.1007/s11356-020-09843-5
  123. Ke et al. (2019) Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa) (pp. 1938-1946) https://doi.org/10.1080/21691401.2019.1614017
  124. Singh et al. (2021) Silver nanoparticles synthesized using Carica papaya leaf extract (AgNPs-PLE) causes cell cycle arrest and apoptosis in human prostate (DU145) cancer cells (pp. 1316-1331) https://doi.org/10.1007/s12011-020-02255-z
  125. Noorbazargan et al. (2021) Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells https://doi.org/10.1186/s13568-021-01216-6
  126. Patel et al. (2016) Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells (pp. 481-490) https://doi.org/10.1093/mutage/gew014
  127. Ranjan et al. (2020) Involvement of Bcl-2 activation and G1 cell cycle arrest in colon cancer cells induced by titanium dioxide nanoparticles synthesized by microwave-assisted hybrid approach https://doi.org/10.3389/fbioe.2020.00606
  128. Kansara et al. (2015) TiO2 nanoparticles induce DNA double strand breaks and cell cycle arrest in human alveolar cells (pp. 204-217) https://doi.org/10.1002/em.21925
  129. Ramalingam et al. (2016) Biogenic gold nanoparticles induce cell cycle arrest through oxidative stress and sensitize mitochondrial membranes in A549 lung cancer cells (pp. 20598-20608) https://doi.org/10.1039/C5RA26781A
  130. Lee et al. (2019) Gold nanoparticles conjugated with resveratrol induce cell cycle arrest in MCF-7 cell lines (pp. 1-6)
  131. Abdel-Ghany et al. (2020) Gold nanoparticles induce G2/M cell cycle arrest and enhance the expression of E-cadherin in breast cancer cells (pp. 926-932) https://doi.org/10.1080/24701556.2020.1728553
  132. Yi et al. (2019) Aiming at cancer in vivo: ferroptosis-inducer delivered by nanoparticles (pp. 621-622) https://doi.org/10.1016/j.chembiol.2019.05.002
  133. Li et al. (2021) The potential application of nanomaterials for ferroptosis-based cancer therapy https://doi.org/10.1088/1748-605X/ac058a
  134. Stockwell et al. (2020) Emerging mechanisms and disease relevance of ferroptosis (pp. 478-490) https://doi.org/10.1016/j.tcb.2020.02.009
  135. Xie et al. (2016) Ferroptosis: process and function (pp. 369-379) https://doi.org/10.1038/cdd.2015.158
  136. Zhao et al. (2019) Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death (pp. 2532-2539) https://doi.org/10.1021/acs.molpharmaceut.9b00132
  137. Cheng et al. (2021) Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin (pp. 5418-5429) https://doi.org/10.7150/thno.53346
  138. Yihui et al. (2021) Research progress on anti-angiogenesis drugs in hepatocellular carcinoma https://doi.org/10.18063/cp.v3i2.319
  139. Garg et al. (2018) Targeting telomerase and topoisomerase-II by natural moieties: an anti-cancer approach (pp. 3-4)
  140. Kashyap et al. (2018) Oncogenic and tumor-suppressive roles of microRNAs with special reference to apoptosis: molecular mechanisms and therapeutic potential https://doi.org/10.1007/s40291-018-0316-1
  141. Lee et al. (2014) Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases (pp. 140-148) https://doi.org/10.1016/j.canlet.2013.12.008
  142. Kim et al. (2014) Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells (pp. 153-163) https://doi.org/10.1016/j.canlet.2014.08.002
  143. Lee et al. (2020) Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity (pp. 1475-1485) https://doi.org/10.1038/s12276-020-00500-y
  144. Yu et al. (2010) Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature (pp. 2278-2292) https://doi.org/10.1016/j.biomaterials.2009.11.047
  145. Kanwar et al. (2011) Antiangiogenic therapy using nanotechnological-based delivery system (pp. 188-202) https://doi.org/10.1016/j.drudis.2011.01.007
  146. Shanmugam et al. (2018) Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis https://doi.org/10.3389/fphar.2018.01294
  147. Lee et al. (2015) Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway (pp. 280-293) https://doi.org/10.1016/j.canlet.2015.02.024
  148. Sethi et al. (2006) Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway (pp. 23425-23435) https://doi.org/10.1074/jbc.M602627200
  149. Tuli et al. (2015) Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects (pp. 71-79) https://doi.org/10.1016/j.lfs.2015.10.021
  150. Majumder et al. (2020) Zinc oxide nanoparticles functionalized on hydrogel grafted silk fibroin fabrics as efficient composite dressing https://doi.org/10.3390/biom10050710
  151. Kovács et al. (2020) Core-shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts https://doi.org/10.1186/s12951-020-0576-x
  152. Shandiz et al. (2020) Evaluation of metastasis suppressor genes expression and in vitro anti-cancer effects of zinc oxide nanoparticles in human breast cancer cell lines mcf-7 and t47d (pp. 9-14)
  153. Katifelis et al. (2020) Ag/Au bimetallic nanoparticles inhibit tumor growth and prevent metastasis in a mouse model (pp. 6019-6032) https://doi.org/10.2147/IJN.S251760
  154. Wang et al. (2013) Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria https://doi.org/10.1038/cddis.2013.314
  155. Song et al. (2014) Cuprous oxide nanoparticles inhibit angiogenesis via down regulation of VEGFR2 expression (pp. 3206-3216) https://doi.org/10.1039/c3nr04363k
  156. Bhattacharya and Mukherjee (2008) Biological properties of “naked” metal nanoparticles (pp. 1289-1306) https://doi.org/10.1016/j.addr.2008.03.013
  157. Arvizo et al. (2011) Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge (pp. 580-587) https://doi.org/10.1016/j.nano.2011.01.011
  158. Giri et al. (2013) Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer https://doi.org/10.1371/journal.pone.0054578
  159. Satapathy et al. (2018) Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner (pp. 883-896) https://doi.org/10.1016/j.nano.2018.01.007
  160. Balkwill and Mantovani (2001) Inflammation and cancer: back to Virchow? (pp. 539-545) https://doi.org/10.1016/S0140-6736(00)04046-0
  161. Korniluk et al. (2017) From inflammation to cancer (pp. 57-62) https://doi.org/10.1007/s11845-016-1464-0
  162. Tuli et al. (2021) Anti-inflammatory and anticancer properties of birch bark-derived betulin: recent developments https://doi.org/10.3390/plants10122663
  163. Grivennikov et al. (2010) Immunity, inflammation, and cancer (pp. 883-899) https://doi.org/10.1016/j.cell.2010.01.025
  164. Gonda et al. (2009) Chronic inflammation, the tumor microenvironment and carcinogenesis (pp. 2005-2013) https://doi.org/10.4161/cc.8.13.8985
  165. Landskron et al. (2014) Chronic inflammation and cytokines in the tumor microenvironment https://doi.org/10.1155/2014/149185
  166. Ilinskaya and Dobrovolskaia (2016) Understanding the immunogenicity and antigenicity of nanomaterials: past, present and future (pp. 70-77) https://doi.org/10.1016/j.taap.2016.01.005
  167. Shah and Dobrovolskaia (2018) Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: therapeutic benefits, toxicity, mechanistic insights, and translational considerations (pp. 977-990) https://doi.org/10.1016/j.nano.2018.01.014
  168. Ignacio et al. (2014) Immunotoxicity of metal oxide nanoparticle: zinc oxide (pp. 237-244) https://doi.org/10.1007/s13273-014-0026-7
  169. Lappas (2015) The immunomodulatory effects of titanium dioxide and silver nanoparticles (pp. 78-83) https://doi.org/10.1016/j.fct.2015.05.015
  170. Klippstein et al. (2010) Silver nanoparticles interactions with the immune system: implications for health and disease (pp. 309-324)
  171. Galbiati et al. (2018) In vitro assessment of silver nanoparticles immunotoxicity (pp. 363-374) https://doi.org/10.1016/j.fct.2017.12.023
  172. Chen et al. (2018) The toxicity of silica nanoparticles to the immune system (pp. 1939-1962) https://doi.org/10.2217/nnm-2018-0076
  173. Zolnik et al. (2010) Minireview: nanoparticles and the immune system (pp. 458-465) https://doi.org/10.1210/en.2009-1082
  174. Dykman and Khlebtsov (2017) Immunological properties of gold nanoparticles (pp. 1719-1735) https://doi.org/10.1039/C6SC03631G
  175. Cruse, J.M., Lewis, R.E.: Illustrated Dictionary of Immunology. CRC Press (2009)
  176. Mohammapdour and Ghandehari (2022) Mechanisms of immune response to inorganic nanoparticles and their degradation products https://doi.org/10.1016/j.addr.2021.114022
  177. Carrouel et al. (2020) Nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in oral care cosmetics: a review of the current situation https://doi.org/10.3390/nano10010140
  178. Mishra et al. (2019) Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases (pp. 1947-1966) https://doi.org/10.1007/s00018-019-03053-0
  179. Sawhney et al. (2007) Expression of NF-κB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco (pp. 2545-2556) https://doi.org/10.1002/ijc.22657
  180. Multhoff et al. (2012) Chronic inflammation in cancer development https://doi.org/10.3389/fimmu.2011.00098
  181. Li et al. (2015) Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers (pp. 5147-5163) https://doi.org/10.18632/oncotarget.2881
  182. Shanmugam et al. (2011) Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model (pp. 1552-1563) https://doi.org/10.1002/ijc.26120
  183. Revell (2006) The biological effect of nanoparticles (pp. 283-298)
  184. Ngobili and Daniele (2016) Nanoparticles and direct immunosuppression (pp. 1064-1073) https://doi.org/10.1177/1535370216650053
  185. Petanidis et al. (2017) Metallodrugs in targeted cancer therapeutics: aiming at chemoresistance-related patterns and immunosuppressive tumor networks (pp. 607-623) https://doi.org/10.2174/0929867324666171116125908
  186. Agarwal et al. (2019) Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: a review (pp. 2561-2572) https://doi.org/10.1016/j.biopha.2018.11.116
  187. Luo et al. (2015) Metal-based nanoparticles and the immune system: activation, inflammation, and potential applications https://doi.org/10.1155/2015/143720
  188. Gustafson et al. (2015) Nanoparticle uptake: the phagocyte problem (pp. 487-510) https://doi.org/10.1016/j.nantod.2015.06.006
  189. Kuhn et al. (2014) Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages (pp. 1625-1636) https://doi.org/10.3762/bjnano.5.174
  190. Li and Monteiro-Riviere (2016) Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles (pp. 3185-3203) https://doi.org/10.2217/nnm-2016-0303
  191. Bahadar et al. (2016) Toxicity of nanoparticles and an overview of current experimental models (pp. 1-11)
  192. Gunawan et al. (2014) Nanoparticle-protein corona complexes govern the biological fates and functions of nanoparticles (pp. 2060-2083) https://doi.org/10.1039/c3tb21526a
  193. Walkey and Chan (2012) Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment (pp. 2780-2799) https://doi.org/10.1039/C1CS15233E
  194. Vinluan and Zheng (2015) Serum protein adsorption and excretion pathways of metal nanoparticles (pp. 2781-2794) https://doi.org/10.2217/nnm.15.97
  195. Schwartz-Albiez et al. (2009) Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation (pp. 43-50) https://doi.org/10.1111/j.1365-2249.2009.04026.x
  196. Aschermann et al. (2010) The other side of immunoglobulin G: suppressor of inflammation (pp. 161-167) https://doi.org/10.1111/j.1365-2249.2009.04081.x
  197. Muñoz et al. (2016) Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation (pp. E5856-E5865) https://doi.org/10.1073/pnas.1602230113
  198. Rahman, M., Laurent, S., Tawil, N., Yahia, L.H., Mahmoudi, M.: Nanoparticle and protein corona. In: Protein-nanoparticle interactions (pp. 21-44). Springer, Berlin, Heidelberg (2013)
  199. James et al. (2015) An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase (pp. 28-38) https://doi.org/10.1016/j.jinorgbio.2014.09.013
  200. Thakor, A.S., Jokerst, J., Zavaleta, C., Massoud, T.F., Gambhir, S.S.: Gold nanoparticles: a revival in precious metal administration to patients (2011).
  201. https://pubmed.ncbi.nlm.nih.gov/21846107/
  202. Sumbayev et al. (2013) Gold nanoparticles downregulate interleukin-1β-induced pro-inflammatory responses (pp. 472-477) https://doi.org/10.1002/smll.201201528
  203. Chen et al. (2013) In vivo study of spherical gold nanoparticles: inflammatory effects and distribution in mice https://doi.org/10.1371/journal.pone.0058208
  204. Huang et al. (2012) Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo (pp. 4483-4493) https://doi.org/10.1021/nn301282m
  205. Fernández et al. (2015) Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells (pp. 1-12) https://doi.org/10.1016/j.biomaterials.2014.11.045
  206. Goodman et al. (2004) Toxicity of gold nanoparticles functionalized with cationic and anionic side chains (pp. 897-900) https://doi.org/10.1021/bc049951i
  207. Liptrott et al. (2014) Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a ’mixed matrix (pp. 2467-2479) https://doi.org/10.2217/nnm.14.38
  208. Deng et al. (2011) Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation (pp. 39-44) https://doi.org/10.1038/nnano.2010.250
  209. Fytianos et al. (2015) Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro (pp. 633-644) https://doi.org/10.1016/j.nano.2014.11.004
  210. Sheikpranbabu et al. (2009) Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells https://doi.org/10.1186/1477-3155-7-8
  211. Yang et al. (2016) Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: Insight into the cytotoxicity and antiangiogenesis (pp. 6679-6692) https://doi.org/10.2147/IJN.S109695
  212. Franková et al. (2016) Effects of silver nanoparticles on primary cell cultures of fibroblasts and keratinocytes in a wound-healing model (pp. e137-e142)
  213. Kim et al. (2016) Aluminum-doped zinc oxide nanoparticles attenuate the TSLP levels via suppressing caspase-1 in activated mast cells (pp. 1407-1416) https://doi.org/10.1177/0885328216629822
  214. Nagajyothi et al. (2015) Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract (pp. 10-17) https://doi.org/10.1016/j.jphotobiol.2015.02.008
  215. Kim and Jeong (2015) Zinc oxide nanoparticles suppress LPS-Induced NF-κB activation by inducing A20, a negative regulator of NF-κB, in RAW 264.7 macrophages (pp. 6509-6515) https://doi.org/10.1166/jnn.2015.10319
  216. Seisenbaeva et al. (2017) Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins https://doi.org/10.1038/s41598-017-15792-w
  217. Palai et al. (2019) Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system (pp. 1-18) https://doi.org/10.1007/s42452-019-0287-9
  218. Benyettou et al. (2015) Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells (pp. 7237-7245) https://doi.org/10.1039/C5TB00994D
  219. Patra et al. (2015) Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics (pp. 298-309) https://doi.org/10.1016/j.msec.2015.04.048
  220. Fan et al. (2011) Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers (pp. 593-600) https://doi.org/10.1016/j.colsurfb.2011.07.048
  221. Shi et al. (2014) A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging (pp. 5847-5861) https://doi.org/10.1016/j.biomaterials.2014.03.042
  222. Sack et al. (2014) Combination of conventional chemotherapeutics with redox-active cerium oxide nanoparticles—a novel aspect in cancer therapy (pp. 1740-1749) https://doi.org/10.1158/1535-7163.MCT-13-0950
  223. Wu et al. (2014) Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells (pp. 1413-1421)
  224. Zhou et al. (2021) Overcoming chemotherapy resistance using pH-sensitive hollow MnO2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma https://doi.org/10.1186/s12951-021-00901-9
  225. Dhar et al. (2009) Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads (pp. 14652-14653) https://doi.org/10.1021/ja9071282
  226. Alamzadeh et al. (2020) Gold nanoparticles promote a multimodal synergistic cancer therapy strategy by co-delivery of thermo-chemo-radio therapy https://doi.org/10.1016/j.ejps.2020.105235
  227. Zhang et al. (2015) Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in rpmi-8226 cells (pp. 3275-3289)
  228. Urandur et al. (2020) Theranostic lyotropic liquid crystalline nanostructures for selective breast cancer imaging and therapy (pp. 522-540) https://doi.org/10.1016/j.actbio.2020.06.023
  229. El Hallal et al. (2021) Effect of cetuximab-conjugated gold nanoparticles on the cytotoxicity and phenotypic evolution of colorectal cancer cells https://doi.org/10.3390/molecules26030567
  230. Ding et al. (2013) The performance of thiol-terminated PEG-paclitaxel-conjugated gold nanoparticles (pp. 10217-10227) https://doi.org/10.1016/j.biomaterials.2013.09.008
  231. Li et al. (2016) Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis (pp. 6693-6702) https://doi.org/10.2147/IJN.S122666
  232. Xing et al. (2021) A carrier-free anti-inflammatory platinum (II) self-delivered nanoprodrug for enhanced breast cancer therapy (pp. 460-471) https://doi.org/10.1016/j.jconrel.2021.01.037
  233. Brown et al. (2010) Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin (pp. 4678-4684) https://doi.org/10.1021/ja908117a
  234. Chen et al. (2007) Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model (pp. 713-722) https://doi.org/10.1021/mp060132k
  235. Thapa et al. (2017) Silver nanoparticle-embedded graphene oxide-methotrexate for targeted cancer treatment (pp. 95-103) https://doi.org/10.1016/j.colsurfb.2017.02.012
  236. Rozalen et al. (2020) Synthesis of controlled-size silver nanoparticles for the administration of methotrexate drug and its activity in colon and lung cancer cells (pp. 10646-10660) https://doi.org/10.1039/C9RA08657A
  237. Sadat Shandiz et al. (2017) Novel imatinib-loaded silver nanoparticles for enhanced apoptosis of human breast cancer MCF-7 cells (pp. 1082-1091) https://doi.org/10.1080/21691401.2016.1202257
  238. Karuppaiah et al. (2020) Synergistic and enhanced anticancer effect of a facile surface modified non-cytotoxic silver nanoparticle conjugated with gemcitabine in metastatic breast cancer cells https://doi.org/10.1016/j.mtcomm.2019.100884
  239. Ding et al. (2019) One-pot synthesis of epirubicin-capped silver nanoparticles and their anticancer activity against hep G2 cells https://doi.org/10.3390/pharmaceutics11030123
  240. Ramezani et al. (2019) Sensitization of resistance ovarian cancer cells to cisplatin by biogenic synthesized silver nanoparticles through p53 activation (pp. 222-231)
  241. Samra et al. (2021) Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma-bearing mice https://doi.org/10.1002/jbt.22869
  242. Tran et al. (2017) Cancer nanomedicine: a review of recent success in drug delivery https://doi.org/10.1186/s40169-017-0175-0
  243. Jain (2003) Nanodiagnostics: application of nanotechnology in molecular diagnostics (pp. 153-161) https://doi.org/10.1586/14737159.3.2.153
  244. Baptista (2014) Nanodiagnostics: leaving the research lab to enter the clinics? (pp. 305-309) https://doi.org/10.1515/dx-2014-0055
  245. Alharbi and Al-sheikh (2014) Role and implications of nanodiagnostics in the changing trends of clinical diagnosis (pp. 109-117) https://doi.org/10.1016/j.sjbs.2013.11.001
  246. Jabir et al. (2018) An overview on the current status of cancer nanomedicines (pp. 911-921) https://doi.org/10.1080/03007995.2017.1421528
  247. Radich et al. (2006) Gene expression changes associated with progression and response in chronic myeloid leukemia (pp. 2794-2799) https://doi.org/10.1073/pnas.0510423103
  248. Waldherr et al. (2005) Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3′-deoxy-3′-18F-fluorothymidine PET (pp. 114-120)
  249. Huang et al. (2007) Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection (pp. 2226-2238) https://doi.org/10.1158/0008-5472.CAN-06-3633
  250. Heath and Davis (2008) Nanotechnology and cancer (pp. 251-265) https://doi.org/10.1146/annurev.med.59.061506.185523
  251. Oldenburg et al. (2005) Magnetomotive contrast for in vivo optical coherence tomography https://doi.org/10.1364/OPEX.13.006597
  252. Yu et al. (2021) Nanoparticles: a new approach to upgrade cancer diagnosis and treatment https://doi.org/10.1186/s11671-021-03489-z
  253. Ito et al. (2005) Medical application of functionalized magnetic nanoparticles (pp. 1-11) https://doi.org/10.1263/jbb.100.1
  254. Estelrich et al. (2015) Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents (pp. 1727-1741)
  255. Laconte et al. (2005) Magnetic nanoparticle probes (pp. 32-38) https://doi.org/10.1016/S1369-7021(05)00893-X
  256. Liu et al. (2013) Targeted dendrimer-stabilized gold nanoparticles for computed tomography imaging of cancer cells (pp. e37-e38) https://doi.org/10.1016/j.jconrel.2013.08.081
  257. Aminabad et al. (2019) Recent advances of gold nanoparticles in biomedical applications: state of the art (pp. 123-137) https://doi.org/10.1007/s12013-018-0863-4
  258. Nejati et al. (2022) Biomedical applications of functionalized gold nanoparticles: a review https://doi.org/10.1007/s10876-020-01955-9
  259. Beik et al. (2017) A nanotechnology-based strategy to increase the efficiency of cancer diagnosis and therapy: folate-conjugated gold nanoparticles (pp. 4399-4416) https://doi.org/10.2174/0929867324666170810154917
  260. Khademi et al. (2020) Corrigendum to “Targeted gold nanoparticles enable molecular CT imaging of head and neck cancer: an in vivo study” [Int. J. Biochem. Cell Biol. 114 (2019) 105554] https://doi.org/10.1016/j.biocel.2020.105695
  261. Hong et al. (2007) The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform (pp. 107-115) https://doi.org/10.1016/j.chembiol.2006.11.015
  262. Bartlett and Davis (2007) Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles (pp. 456-468) https://doi.org/10.1021/bc0603539
  263. Shi et al. (2020) Evolving role of biomaterials in diagnostic and therapeutic radiation oncology (pp. 233-240) https://doi.org/10.1016/j.bioactmat.2020.01.011
  264. Zhang et al. (2019) Multitargeted nanoparticles deliver synergistic drugs across the blood-brain barrier to brain metastases of triple negative breast cancer cells and tumor-associated macrophages https://doi.org/10.1002/adhm.201900543
  265. Jaishankar et al. (2014) Toxicity, mechanism and health effects of some heavy metals (pp. 60-72) https://doi.org/10.2478/intox-2014-0009
  266. Jan et al. (2015) Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants (pp. 29592-29630) https://doi.org/10.3390/ijms161226183
  267. Medici et al. (2021) An updated overview on metal nanoparticles toxicity (pp. 17-26) https://doi.org/10.1016/j.semcancer.2021.06.020
  268. Pan et al. (2007) Size-dependent cytotoxicity of gold nanoparticles (pp. 1941-1949) https://doi.org/10.1002/smll.200700378
  269. Sharma et al. (2018) Recent advances in metal nanoparticles in cancer therapy (pp. 617-632) https://doi.org/10.1080/1061186X.2017.1400553
  270. Chia and Leong (2016) Reducing ZnO nanoparticles toxicity through silica coating https://doi.org/10.1016/j.heliyon.2016.e00177
  271. Pérez-Campaña et al. (2013) Biodistribution of different sized nanoparticles assessed by positron emission tomography: a general strategy for direct activation of metal oxide particles (pp. 3498-3505) https://doi.org/10.1021/nn400450p
  272. Bailly et al. (2019) In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles https://doi.org/10.1038/s41598-019-48748-3
  273. Leavens et al. (2012) In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps (pp. 913-919) https://doi.org/10.1002/jat.2750
  274. Xue et al. (2012) Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice (pp. 890-899) https://doi.org/10.1002/jat.2742
  275. Glazer et al. (2011) Biodistribution and acute toxicity of naked gold nanoparticles in a rabbit hepatic tumor model (pp. 459-468) https://doi.org/10.3109/17435390.2010.516026
  276. Lankveld et al. (2011) Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats (pp. 339-349) https://doi.org/10.2217/nnm.10.122
  277. Arvizo et al. (2011) Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles https://doi.org/10.1371/journal.pone.0024374
  278. Schleh et al. (2013) Biodistribution of inhaled gold nanoparticles in mice and the influence of surfactant protein D (pp. 24-30) https://doi.org/10.1089/jamp.2011.0951
  279. El-Sayed et al. (2013) Tissue distribution and efficacy of gold nanorods coupled with laser induced photoplasmonic therapy in Ehrlich carcinoma solid tumor model https://doi.org/10.1371/journal.pone.0076207
  280. Lee et al. (2010) Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method https://doi.org/10.1371/journal.pone.0009536
  281. Cole et al. (2011) Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting (pp. 2183-2193) https://doi.org/10.1016/j.biomaterials.2010.11.040
  282. Zhang et al. (2013) Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform (pp. 3892-3902) https://doi.org/10.1021/mp400360q
  283. Ma et al. (2008) Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers (pp. 217-226) https://doi.org/10.1016/j.ijpharm.2007.11.036
  284. Li et al. (2012) Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice (pp. 746-756) https://doi.org/10.3109/17435390.2011.620717
  285. Wang et al. (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration (pp. 176-185) https://doi.org/10.1016/j.toxlet.2006.12.001
  286. Yamashita et al. (2011) Silica and titanium dioxide nanoparticles cause pregnancy complications in mice (pp. 321-328) https://doi.org/10.1038/nnano.2011.41
  287. Malaikolundhan et al. (2020) Anticarcinogenic effect of gold nanoparticles synthesized from Albizia Lebbeck on HCT-116 colon cancer cell lines (pp. 1206-1213) https://doi.org/10.1080/21691401.2020.1814313
  288. Liu et al. (2015) Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells (pp. 6075-6087)
  289. Sun et al. (2019) Anticancer activity of green synthesised gold nanoparticles from Marsdenia tenacissima inhibits A549 cell proliferation through the apoptotic pathway (pp. 4012-4019) https://doi.org/10.1080/21691401.2019.1575844
  290. Yun et al. (2020) Biosynthesis of gold nanoparticles using Vitex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines https://doi.org/10.1016/j.jphotobiol.2019.111749
  291. Li et al. (2019) Synthesis and characterization of gold nanoparticles from Marsdenia tenacissima and its anticancer activity of liver cancer HepG2 cells (pp. 3029-3036) https://doi.org/10.1080/21691401.2019.1642902
  292. Li et al. (2019) Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1) (pp. 1610-1616) https://doi.org/10.1080/21691401.2019.1594860
  293. Wang et al. (2019) Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC-1) (pp. 1617-1627) https://doi.org/10.1080/21691401.2019.1594862
  294. Daei et al. (2021) Anticancer effects of gold nanoparticles by inducing apoptosis in bladder cancer 5637 cells https://doi.org/10.1007/s12011-021-02895-9
  295. Wu et al. (2019) Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells (pp. 512-523) https://doi.org/10.1080/21691401.2018.1560305
  296. Ke et al. (2019) Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa) (pp. 1938-1946) https://doi.org/10.1080/21691401.2019.1614017
  297. Li et al. (2020) Anticancer and genotoxicity effect of (Clausena lansium (Lour.) Skeels) Peel ZnONPs on neuroblastoma (SH-SY5Y) cells through the modulation of autophagy mechanism https://doi.org/10.1016/j.jphotobiol.2019.111748
  298. Cheng et al. (2020) Green synthesized zinc oxide nanoparticles regulates the apoptotic expression in bone cancer cells MG-63 cells https://doi.org/10.1016/j.jphotobiol.2019.111644
  299. Berehu, H.M., S, A., Khan, M.I., Chakraborty, R., Lavudi, K., Penchalaneni, J., Mohapatra, B., Mishra, A., Patnaik, S.: Cytotoxic potential of biogenic zinc oxide nanoparticles synthesized from swertia chirayita leaf extract on colorectal cancer cells. Front. Bioeng. Biotechnol.
  300. 9
  301. , 788527–788527 (2021)
  302. Tang et al. (2020) Synthesis and characterization of zinc oxide nanoparticles from Morus nigra and its anticancer activity of AGS gastric cancer cells https://doi.org/10.1016/j.jphotobiol.2019.111698
  303. Duan et al. (2020) Zinc oxide nanoparticles synthesized from Cardiospermum halicacabum and its anticancer activity in human melanoma cells (A375) through the modulation of apoptosis pathway https://doi.org/10.1016/j.jphotobiol.2019.111718
  304. Thomas et al. (2021) Synthesis and characterization of zinc oxide nanoparticles of solanum nigrum and its anticancer activity via the induction of apoptosis in cervical cancer https://doi.org/10.1007/s12011-021-02898-6
  305. Jabir et al. (2021) Green synthesis of silver nanoparticles using Annona muricata extract as an inducer of apoptosis in cancer cells and inhibitor for NLRP3 inflammasome via enhanced autophagy (pp. 1-22) https://doi.org/10.3390/nano11020384
  306. Venkatadri et al. (2020) Green synthesis of silver nanoparticles using aqueous rhizome extract of Zingiber officinale and Curcuma longa: In-vitro anti-cancer potential on human colon carcinoma HT-29 cells (pp. 2980-2986) https://doi.org/10.1016/j.sjbs.2020.09.021
  307. Elhawary et al. (2020) Green synthesis of silver nanoparticles using extract of Jasminum officinal l. Leaves and evaluation of cytotoxic activity towards bladder (5637) and breast cancer (mcf-7) cell lines (pp. 9771-9781) https://doi.org/10.2147/IJN.S269880
  308. Zulkifli, N.I., Muhamad, M., Zain, N.N.M., Tan, W.N., Yahaya, N., Bustami, Y., Aziz, A.A., Kamal, N.N.S.N.M.: A bottom-up synthesis approach to silver nanoparticles induces anti-proliferative and apoptotic activities against MCF-7, MCF-7/TAMR-1 and MCF-10A human breast cell lines. Molecules.
  309. 25
  310. , 4332 (2020).
  311. He et al. (2016) Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo (pp. 1879-1887) https://doi.org/10.2147/IJN.S103695
  312. Mousavi et al. (2018) Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS) (pp. 499-510) https://doi.org/10.1080/21691401.2018.1430697
  313. Bin-Jumah et al. (2020) Effects of green silver nanoparticles on apoptosis and oxidative stress in normal and cancerous human hepatic cells in vitro (pp. 1537-1548) https://doi.org/10.2147/IJN.S239861
  314. Murugesan et al. (2019) Effects of green synthesized silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models (pp. 5257-5270) https://doi.org/10.2147/IJN.S202404
  315. Zhang, K., Liu, X., Samuel Ravi, S.O.A., Ramachandran, A., Aziz Ibrahim, I.A., M. Nassir, A., Yao, J.: Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines. Artif. Cells, Nanomedicine Biotechnol.
  316. 47
  317. , 2846–2854 (2019)
  318. Namvar et al. (2014) Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract (pp. 2479-2488) https://doi.org/10.2147/IJN.S59661
  319. Shahabadi et al. (2016) Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe3O4 at SiO2 nanoparticles (pp. 213-222) https://doi.org/10.1016/j.colsurfb.2016.01.054
  320. Sulaiman et al. (2018) Biosynthesis, characterization of magnetic iron oxide nanoparticles and evaluations of the cytotoxicity and DNA damage of human breast carcinoma cell lines (pp. 1215-1229) https://doi.org/10.1080/21691401.2017.1366335
  321. Shejawal et al. (2021) Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell https://doi.org/10.1007/s10856-021-06489-8
  322. Muhammad et al. (2019) Papaver somniferum L mediated novel bioinspired lead oxide (PbO) and iron oxide (Fe2O3) nanoparticles: in-vitro biological applications, biocompatibility and their potential towards HepG2 cell line https://doi.org/10.1016/j.msec.2019.109740
  323. Calmon et al. (2012) A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases (pp. 177-184) https://doi.org/10.1016/j.colsurfb.2012.05.026
  324. Shejawal, K.P., Randive, D.S., Bhinge, S.D., Bhutkar, M.A., Todkar, S.S., Mulla, A.S., Jadhav, N.R.: Green synthesis of silver, iron and gold nanoparticles of lycopene extracted from tomato: their characterization and cytotoxicity against COLO320DM, HT29 and Hella cell. J. Mater. Sci. Mater. Med.
  325. 32
  326. (2021).
  327. Gnanavel et al. (2017) Biosynthesis and characterization of copper oxide nanoparticles and its anticancer activity on human colon cancer cell lines (HCT-116) (pp. 133-138) https://doi.org/10.1016/j.jphotobiol.2017.05.001
  328. EsmaeiliGovarchinGhaleh et al. (2019) Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy (pp. 1396-1403) https://doi.org/10.1080/21691401.2019.1600529
  329. Manikandan et al. (2021) Biofabrication of ecofriendly copper oxide nanoparticles using Ocimum americanum aqueous leaf extract: analysis of in vitro antibacterial, anticancer, and photocatalytic activities (pp. 33927-33941) https://doi.org/10.1007/s11356-020-12108-w
  330. Chinnathambi et al. (2021) Biogenesis of copper nanoparticles (Cu-NPs) using leaf extract of Allium noeanum, antioxidant and in-vitro cytotoxicity (pp. 500-510) https://doi.org/10.1080/21691401.2021.1926275
  331. Miri et al. (2018) Biosynthesis and cytotoxic activity of lead oxide nanoparticles (pp. 567-572) https://doi.org/10.1080/17518253.2018.1547926
  332. Al-Jameel et al. (2021) Anti-microbial and anti-cancer activities of Mn0.5Zn0.5DyxFe2-xO4 (x ≤ 0.1) nanoparticles (pp. 493-499) https://doi.org/10.1080/21691401.2021.1938592
  333. Jabbari et al. (2018) Assessment of synergistic effect of combining hyperthermia with irradiation and calcium carbonate nanoparticles on proliferation of human breast adenocarcinoma cell line (MCF-7 cells) (pp. 364-372) https://doi.org/10.1080/21691401.2018.1457537