10.1007/s40097-021-00455-0

Visible light-driven photoelectrochemical enzyme biosensor based on reduced graphene oxide/titania for detection of glucose

  • Chunqi Zhao1,
  • Tao Jing1,
  • Jingzhi Tian1,
  • Jiang Guo2,
  • Min Wu1,
  • Danni Shi1,
  • Zhiyuan Zhao1,
  • Zhanhu Guo*3,
  1. College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, CN
  2. School of Materials Science and Engineering, Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials, Shaanxi University of Science & Technology, Xi’an, 710021, CN Advanced Materials Division, Engineered Multifunctional Composites (EMC) Nanotech LLC., Knoxville, TN, 37934, US
  3. Integrated Composites Laboratory (ICL), Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, 37996, US

Published in Issue 16-10-2021

How to Cite

Zhao, C., Jing, T., Tian, J., Guo, J., Wu, M., Shi, D., Zhao, Z., & Guo, Z. (2021). Visible light-driven photoelectrochemical enzyme biosensor based on reduced graphene oxide/titania for detection of glucose. Journal of Nanostructure in Chemistry, 12(2 (April 2022). https://doi.org/10.1007/s40097-021-00455-0
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Abstract

Abstract Developing a rapid and sensitive photo-electrochemical (PEC) sensing platform for glucose detection is highly desirable. Herein, a visible light-driven PEC enzyme biosensor for sensitive detection of glucose was proposed, employing reduced graphene oxide/titania (TiO 2 ) nanotubes (RGO/TNTs) as photoactive materials and glucose oxidase (GOD) as the identification element. The RGO/TNTs composites were synthesized via a facile hydrothermal process. Notably, the unique nanostructure system significantly increases the absorption in the visible region and effectively separates the photo-generated electron–hole pairs, which is essential for promoting the PEC activity. In the presence of dissolved oxygen, the GOD immobilized on the modified electrode could specifically catalyze the electro-oxidation of glucose to produce H 2 O 2 , resulting in an increase of photocurrent intensity. Based on the variation of the photocurrent response, the constructed PEC enzyme biosensor exhibited high sensitivity with a wide linear range from 10 –2 to 10 mM and a low detection limit of 5.0 μΜ. Meanwhile, the potential applicability of the PEC enzyme biosensor was evaluated by detecting glucose in human serum samples, and satisfactory results were obtained. Graphic abstract The PEC enzyme biosensor based on RGO/TNTs composites successfully realized the sensitive detection of glucose and displayed good selectivity, high stability and satisfactory repeatability.

Keywords

  • Visible light-driven,
  • RGO/TNTs composites,
  • Photo-electrochemical enzyme biosensor,
  • Glucose

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