Nano-SiO2/Taurine as a new natural based catalyst for synthesis of hexahydroquinolines derivative

Authors

• Saeed Sharifi Sharifabad ¹
• Bi Bi Fatemeh Mirjalili * ¹
• Abdolhamid Bamoniri ²

1. Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, Iran
2. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran

Abstract

In this research work, Nano-SiO₂/Taurine was synthesized and characterized by FT-IR, energy dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), X-ray diffraction patterns (XRD) ,Thermogravimetric analysis (TGA) and MAP analysis. Nano-SiO₂/Taurine has considerable benefits such as simple preparation protocol, simple handling, high acidic property, reusability and high stability. Nano-SiO₂/Taurine was used as a catalyst for the synthesis of hexahydroquinolines by the reaction of ethyl acetoacetate, dimedone and ammonium acetate with various aldehydes. These reactions were carried out under solvent-free conditions at 85 ^°C. The present protocol is simple, eco-friendly and efficient. The hexahydroquinolines were produced at high yields and short reaction times.

Highlights

• Nano-SiO₂/Taurine was prepared via reaction between nano silicagel and taurine.
• Nano-SiO₂/Taurine was characterized by FT-IR, energy dispersive X-ray analysis (EDX), X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), Thermogravimetric analysis (TGA) and MAP analysis.
• Nano-SiO₂/Taurine was applied for the synthesis of hexahydroquinoline derivatives by the condensation reaction between ethyl acetoacetate, dimedone, ammonium acetate and various aldehydes.
• Nano-SiO₂/Taurine has considerable benefits such as simple preparation protocol, simple handling, high acidic property, reusability and high stability.

Graphical Abstract

Keywords

• Dimedone
• Sulfated Zirconia.
• Nano-SiO2/Taurine
• Hexahydroquinoline
• Ethyl acetoacetate