10.1007/s40089-016-0198-3

Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum

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  • Ruhollah Dorostkar1,
  • Majdedin Ghalavand1,
  • Ali Nazarizadeh2,
  • Mahdi Tat1,
  • Mohammad Sadegh Hashemzadeh*1,
  1. Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR
  2. Department of Clinical Pathology and Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, IR
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Published in Issue 2017-04-07

How to Cite

Dorostkar, R., Ghalavand, M., Nazarizadeh, A., Tat, M., & Hashemzadeh, M. S. (2017). Anthelmintic effects of zinc oxide and iron oxide nanoparticles against Toxocara vitulorum. International Nano Letters, 7(2 (June 2017). https://doi.org/10.1007/s40089-016-0198-3
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Abstract

Abstract In the present study, zinc oxide (ZnO) and iron oxide (FeO) nanoparticles were examined for their possible, in vitro anthelmintic effects against Toxocara vitulorum. The worms were incubated for 24 h with different concentrations (0.004, 0.008 and 0.012% w/v) of the nanoparticles. The parasite mobility, mortality, superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) level were recorded at different time intervals. The results showed that both of the nanoparticles could significantly decrease worm’s mobility, increase mortality rate as well as elevate MDA and NO content as compared to control group in a time- and concentration-dependent manner. SOD activity was elevated with the low concentration of the nanoparticles but it was decreased in higher ones. It can be concluded that ZnO and FeO nanoparticles exert their anthelmintic effects via induction of oxidative/nitrosative stress.

Keywords

  • Toxocara vitulorum,
  • Anthelmintic,
  • Zinc oxide,
  • FeOn oxide,
  • Nanoparticle
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References

  1. Khan et al. (2015) Anthelmintic effect of biocompatible zinc oxide nanoparticles (ZnO NPs) on Gigantocotyle explanatum, a neglected parasite of Indian Water Buffalo 10(7) https://doi.org/10.1371/journal.pone.0133086
  2. Peter and Deogracious (2006) The in vitro ascaricidal activity of selected indigenous medicinal plants used in ethno veterinary practices in Uganda 3(2) (pp. 94-103)
  3. Aydin et al. (2006) Prevalence of Toxocara vitulorum in Hakkari eastern region of Turkey 50(1)
  4. Woodbury et al. (2012) Toxocara vitulorum in a bison (Bison bison) herd from western Canada 53(7)
  5. Davila et al. (2010) Toxocara vitulorum in beef calves in North Central Florida 168(3–4) (pp. 261-263) https://doi.org/10.1016/j.vetpar.2009.11.026
  6. Mahieu and Naves (2008) Incidence of Toxocara vitulorum in Creole calves of Guadeloupe 40(4) (pp. 243-248) https://doi.org/10.1007/s11250-007-9094-1
  7. Van Wky et al. (1999) Anthelmintic resistance in South Africa: surveys indicate an extremely serious situation in sheep and goat farming 66(4)
  8. Dizaj et al. (2014) Antimicrobial activity of the metals and metal oxide nanoparticles (pp. 278-284) https://doi.org/10.1016/j.msec.2014.08.031
  9. Mody et al. (2010) Introduction to metallic nanoparticles 2(4) (pp. 282-289) https://doi.org/10.4103/0975-7406.72127
  10. Zhang et al. (2011) The application of carbon nanotubes in target drug delivery systems for cancer therapies 6(1) https://doi.org/10.1186/1556-276X-6-555
  11. De et al. (2008) Applications of nanoparticles in biology 20(22) (pp. 4225-4241) https://doi.org/10.1002/adma.200703183
  12. Wang et al. (2012) Antibacterial effects of zinc oxide nanoparticles on Escherichia coli K 88 11(44) (pp. 10248-10254)
  13. You et al. (2011) Bacteria and bacteriophage inactivation by silver and zinc oxide nanoparticles 85(2) (pp. 161-167) https://doi.org/10.1016/j.colsurfb.2011.02.023
  14. Kim et al. (2012) Antifungal effects of silver nanoparticles (AgNPs) against various plant pathogenic fungi 40(1) (pp. 53-58) https://doi.org/10.5941/MYCO.2012.40.1.053
  15. Baiocco et al. (2010) Inhibitory effect of silver nanoparticles on trypanothione reductase activity and Leishmania infantum proliferation 2(3) (pp. 230-233) https://doi.org/10.1021/ml1002629
  16. Delavari et al. (2014) In vitro study on cytotoxic effects of ZnO nanoparticles on promastigote and amastigote forms of Leishmania major 9(1) (pp. 6-13)
  17. Premanathan et al. (2011) Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation 7(2) (pp. 184-192) https://doi.org/10.1016/j.nano.2010.10.001
  18. Laurent et al. (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications 108(6) (pp. 2064-2110) https://doi.org/10.1021/cr068445e
  19. Shalaby and El-Moghazy (2013) In vitro effect of Nigella sativa oil on adult Toxocara vitulorum 16(22) (pp. 1557-1562) https://doi.org/10.3923/pjbs.2013.1557.1562
  20. Hanser et al. (2003) In vitro studies on the effects of flubendazole against Toxocara canis and Ascaris suum 89(1) (pp. 63-74) https://doi.org/10.1007/s00436-002-0668-6
  21. Sun et al. (1988) A simple method for clinical assay of superoxide dismutase 34(3) (pp. 497-500)
  22. Nair and Turner (1984) The thiobarbituric acid test for lipid peroxidation: structure of the adduct with malondialdehyde 19(10) (pp. 804-805) https://doi.org/10.1007/BF02534475
  23. Green et al. (1982) Analysis of nitrate, nitrite, and [15 N] nitrate in biological fluids 126(1) (pp. 131-138) https://doi.org/10.1016/0003-2697(82)90118-X
  24. Sazgarnia et al. (2013) Antiparasitic effects of gold nanoparticles with microwave radiation on promastigotes and amastigotes of Leishmania major 29(1) (pp. 79-86) https://doi.org/10.3109/02656736.2012.758875
  25. Shalaby (2013) Anthelmintics resistance; how to overcome it? 8(1) (pp. 18-32)
  26. Chang et al. (2012) The toxic effects and mechanisms of CuO and ZnO nanoparticles 5(12) https://doi.org/10.3390/ma5122850
  27. Tiwari et al. (2013) Markers of oxidative stress during diabetes mellitus https://doi.org/10.1155/2013/378790
  28. Kriegel and Schellenberger (2007) Springer-Lehrbuch
  29. Henkle-Dührsen and Kampkötter (2001) Antioxidant enzyme families in parasitic nematodes 114(2) (pp. 129-142) https://doi.org/10.1016/S0166-6851(01)00252-3
  30. Nazarizadeh, A., Asri-Rezaie, S.: Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats. AAPS PharmSciTech.
  31. 17
  32. (4), 834–843 (2016). doi:
  33. 10.1208/s12249-015-0405-y
  34. Soneja et al. (2005) Role of nitric oxide, nitroxidative and oxidative stress in wound healing
  35. Unfried et al. (2007) Cellular responses to nanoparticles: target structures and mechanisms 1(1) (pp. 52-71) https://doi.org/10.1080/00222930701314932
  36. Wolstenholme et al. (2004) Drug resistance in veterinary helminths 20(10) (pp. 469-476) https://doi.org/10.1016/j.pt.2004.07.010