10.1007/s40089-023-00401-8

Green synthesis of zinc oxide nanoparticles using Croton joufra leaf extract, characterization and antidiabetic activity

  • Abu Md Ashif Ikbal1,
  • Amlanjyoti Rajkhowa2,
  • Waikhom Somraj Singh3,
  • Kuntal Manna*1,
  1. Natural Cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Agartala, Tripura, 799022, IN
  2. Natural Cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Agartala, Tripura, 799022, IN School of Pharmacy, Faculty of Medical Sciences, Arunachal University of Studies, Namsai, Arunachal Pradesh, IN
  3. Natural Cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Agartala, Tripura, 799022, IN Faculty of Allied Health Sciences, The ICFAI University Tripura, Agartala, Tripura, 799210, IN

Published 2023-03-22

How to Cite

Ikbal, A. M. A., Rajkhowa, A., Singh, W. S., & Manna, K. (2023). Green synthesis of zinc oxide nanoparticles using Croton joufra leaf extract, characterization and antidiabetic activity. International Nano Letters , 13(3-4 (December 2023). https://doi.org/10.1007/s40089-023-00401-8

Abstract

Abstract In this current investigation, zinc oxide nanoparticles (ZnONPs) were synthesized from Croton joufra leaves extract containing zinc nitrate as a precursor. Reducing zinc nitrate to free zinc nanoparticles under the impact of phytoconstituents of Croton joufra aqueous leaves extracts has successfully synthesized Croton joufra zinc oxide nanoparticles (Cj-ZnO NPs). The ultraviolet–visible (UV–Vis) spectroscopy revealed the maximum surface plasmon resonance at 346 nm. The Fourier transform infrared (FT-IR) spectroscopy showed a broad peak at 3269.53 cm −1 , 1605.67 cm −1 , 1070.14 cm −1 , and 1042.35 cm −1 disclosing that the nanoparticle contained O–H carboxylic acid stretching, C = N bond, and C–O stretching vibrations. The highly stable Cj-ZnO NPs are repelled by one another, as exhibited by the negative charge of the zeta potential value (− 22.9 mV). The morphological characteristics of the synthesized nanoparticle were analyzed with X-ray diffraction (XRD), field emission scanning electron microscopy–energy dispersive X-ray (FESEM-EDX), scanning electron microscopy (SEM), transmittance electron microscopy (TEM), and differential scanning calorimetry (DSC) techniques. The synthesized Cj-ZnO NPs showed in vitro antidiabetic activity with an IC 50 value of 774.86 µg/ml, while metformin was used as a standard drug with an IC 50 value of 538.24 µg/ml. This study demonstrates the possibility of using Cj-ZnONPs to treat diabetes.

Keywords

  • Zinc oxide nanoparticles,
  • Croton joufra,
  • Nanonization,
  • Antidiabetic activity

References

  1. Roco (2020) Principles of convergence in nature and society and their application: from nanoscale, digits, and logic steps to global progress 22(11) (pp. 1-27) https://doi.org/10.1007/s11051-020-05032-0
  2. Lata et al. (2017) Role of nanotechnology in drug delivery (pp. 1-29)
  3. Becheri et al. (2008) Synthesis and characterization of zinc oxide nanoparticles: application to textiles as UV-absorbers 10(4) (pp. 679-689) https://doi.org/10.1007/s11051-007-9318-3
  4. Balasubramaniam et al. (2020) Antibacterial and antiviral functional materials: chemistry and biological activity toward tackling COVID-19-like pandemics 4(1) (pp. 8-54) https://doi.org/10.1021/acsptsci.0c00174
  5. Davatgaran-Taghipour et al. (2017) Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective https://doi.org/10.2147/IJN.S131973
  6. Nuruzzaman et al. (2016) Nanoencapsulation, nano-guard for pesticides: a new window for safe application 64(7) (pp. 1447-1483) https://doi.org/10.1021/acs.jafc.5b05214
  7. Brigger et al. (2012) Nanoparticles in cancer therapy and diagnosis (pp. 24-36) https://doi.org/10.1016/j.addr.2012.09.006
  8. Kadian (2018) Nanoparticles: a promising drug delivery approach 11(1) (pp. 30-35) https://doi.org/10.22159/ajpcr.2018.v11i1.22035
  9. Subramaniam et al. (2020) Assessment of the cytotoxicity of cerium, tin, aluminum, and zinc oxide nanoparticles on human cells 22(12) (pp. 1-5) https://doi.org/10.1007/s11051-020-05102-3
  10. Manna et al. (2015) Microwave assisted biogenic synthesis of metal nanoparticles using plant extract: characterization and antimicrobial activity 1(2) (pp. 87-94) https://doi.org/10.2174/2213529402666160511125216
  11. Bhande et al. (2013) Enhanced synergism of antibiotics with zinc oxide nanoparticles against extended spectrum β-lactamase producers implicated in urinary tract infections 15(1) (pp. 1-3) https://doi.org/10.1007/s11051-012-1413-4
  12. Mao et al. (2016) Functional nanoparticles for magnetic resonance imaging 8(6) (pp. 814-841)
  13. Wen et al. (2017) Nanotechnology-based drug delivery systems for Alzheimer's disease management: technical, industrial, and clinical challenges (pp. 95-107) https://doi.org/10.1016/j.jconrel.2016.11.025
  14. Sportelli et al. (2015) Recent Trends in the Electrochemical Synthesis of Zinc Oxide Nano-Colloids (pp. 1158-1172) LLC
  15. Agarwal et al. (2017) A review on green synthesis of zinc oxide nanoparticles—an eco-friendly approach (pp. 406-413) https://doi.org/10.1016/j.reffit.2017.03.002
  16. Srivastava et al. (2021) Biological nanofactories: using living forms for metal nanoparticle synthesis (pp. 245-265)
  17. Ahmad et al. (2020) Metal-oxide powder technology in biomedicine (pp. 121-168) Elsevier https://doi.org/10.1016/B978-0-12-817505-7.00007-5
  18. Happy et al. (2019) Phyto-assisted synthesis of zinc oxide nanoparticles using Cassia alata and its antibacterial activity against Escherichia coli (pp. 208-211)
  19. Schuster and Duvuuri (2002) Diabetes mellitus 19(1) (pp. 79-107) https://doi.org/10.1016/S0891-8422(03)00082-X
  20. San (2019) The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus https://doi.org/10.1016/j.lfs.2019.117011
  21. Paul and Majumdar (2020) In-Vitro antidiabetic propensities, phytochemical analysis, and mechanism of action of commercial antidiabetic polyherbal formulation “mehon” 79(1) (pp. 1-7)
  22. Mishra et al. (2017) Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications 22(12) (pp. 1825-1834) https://doi.org/10.1016/j.drudis.2017.08.006
  23. Singh et al. (2021) Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences 11(40) (pp. 24722-24746) https://doi.org/10.1039/D1RA04273D
  24. Surwade et al. (2020) Impact of the changes in bacterial outer membrane structure on the anti-bacterial activity of zinc oxide nanoparticles 22(2) (pp. 1-8) https://doi.org/10.1007/s11051-020-4767-z
  25. Chen et al. (2013) Nanomaterials in medicine and pharmaceuticals: nanoscale materials developed with less toxicity and more efficacy 5(2) (pp. 61-79) https://doi.org/10.1515/ejnm-2013-0003
  26. Azwanida (2015) A review on the extraction methods use in medicinal plants, principle, strength and limitation 4(196) (pp. 2167-2412)
  27. Elumalai et al. (2015) Green synthesis of zinc oxide nanoparticles using Moringaoleifera leaf extract and evaluation of its antimicrobial activity. Spectrochimica Acta Part A: Mol (pp. 158-164) https://doi.org/10.1016/j.saa.2015.02.011
  28. Khouri et al. (2014) Determination and prediction of physical properties of cellulose nanocrystals from dynamic light scattering measurements 16(7) (pp. 1-4) https://doi.org/10.1007/s11051-014-2499-7
  29. Wickramaratne et al. (2016) In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina 16(1) (pp. 1-5) https://doi.org/10.1186/s12906-016-1452-y
  30. AAT Bioquest, Inc. (2022, July 5). Quest Graph™ IC
  31. 50
  32. Calculator. AAT Bioquest.
  33. https://www.aatbio.com/tools/ic50-calculator
  34. .
  35. Khademalrasool et al. (2021) Investigation of shape effect of silver nanostructures and governing physical mechanisms on photo-activity: zinc oxide/silver plasmonic photocatalyst 32(6) (pp. 1844-1857) https://doi.org/10.1016/j.apt.2021.03.008
  36. Boluk and Danumah (2014) Analysis ofcellulose nanocrystal rod lengths by dynamic lightscattering and electron microscopy https://doi.org/10.1007/s11051-013-2174-4
  37. Lim et al. (2016) NanoCrystalline Cellulose isolated from oil palm empty fruit bunch and its potential in cadmium metal removal https://doi.org/10.1051/matecconf/20165904002)