10.1186/2228-5326-3-13

Convenient, efficient, and green method for synthesis of bis(indolyl)methanes with nano SIO2 under ultrasonic irradiation

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  • Keivan Ghodrati*1,
  • Saied Hosseine Hosseini2,
  • Rasol Mosaedi2,
  • Changiz Karami1,
  • Fariba Maleki1,
  • Azita Farrokhi1,
  • Zohreh Hamidi1,
  1. Department of Chemistry, Faculty of Science, Islamic Azad University (Kermanshah Branch), Kermanshah, 67189, IR
  2. Department of Chemistry, Faculty of Science, Islamic Azad University (Saveh Branch), Saveh, IR
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Published in Issue 2013-03-07

How to Cite

Ghodrati, K., Hosseini, S. H., Mosaedi, R., Karami, C., Maleki, F., Farrokhi, A., & Hamidi, Z. (2013). Convenient, efficient, and green method for synthesis of bis(indolyl)methanes with nano SIO2 under ultrasonic irradiation. International Nano Letters, 3(1 (December 2013). https://doi.org/10.1186/2228-5326-3-13
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Abstract

Abstract A green and efficient procedure for the preparation of bis (indolyl)methanes via the condensation of indoles with various carbonyl compounds in the presence of catalytic amount of nanosilica gel under ultrasonic irradiation in good to excellent yields (83% to 94% ) in solvent-free condition is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity, and excellent yields are the main advantages of this procedure. Native nanosilica gel was used as an inexpensive and readily available catalyst without any support of reagent or modification on it. The reaction is carried out in solvent-free condition in the absence of ultrasonic irradiation at 80°C, too. This methodology offers significant improvements for the synthesis of bis (indolyl)methanes with regard to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts and solvents. Recovery and recycling of the silica nanoparticle catalyst were also described.

Keywords

  • nano SiO2,
  • nano catalysis, bis(indolyl)methane ultrasonic irradiation
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