10.1186/2228-5326-3-28

Evaluation of synthesized platinum nanoparticles on the MCF-7 and HepG-2 cancer cell lines

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  • Hadi Mohammadi*1,
  • Anita Abedi1,
  • Azim Akbarzadeh2,
  • Mohammad Javad Mokhtari3,
  • Hasan Ebrahimi Shahmabadi2,
  • Mohamad Reza Mehrabi2,
  • Saifuddin Javadian4,
  • Mohsen Chiani2,
  1. Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, IR
  2. Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, IR
  3. Department of Biology, Islamic Azad University, Zarghan Branch, Zarghan, IR
  4. Department of Biochemistry, Pasteur Institute of Iran, Tehran, IR
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Published in Issue 2013-04-26

How to Cite

Mohammadi, H., Abedi, A., Akbarzadeh, A., Mokhtari, M. J., Shahmabadi, H. E., Mehrabi, M. R., Javadian, S., & Chiani, M. (2013). Evaluation of synthesized platinum nanoparticles on the MCF-7 and HepG-2 cancer cell lines. International Nano Letters, 3(1 (December 2013). https://doi.org/10.1186/2228-5326-3-28
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Abstract

Abstract Platinum nanoparticles (PNPs) were synthesized by chemical reduction of potassium hexachloroplatinate (IV) with trisodium citrate under vigorous stirring and addition of sodium dodecyl sulfate as stabilizer reagent. Reducing agent was chosen depending on the oxidation reactions and potential values of the chemical materials used in the experiment. The aim of this study is to investigate the effects of PNPs on the different cancer cell lines and cytotoxicity study of this nanomaterial. The morphology of PNPs was investigated by scanning electron microscope (XL30, Philips Electronics, Amsterdam, The Netherlands) with the ability to perform elemental analysis by EDX. Malvern Zetasizer 3000 HSA (Malvern Instruments, Worcestershire, UK) was used to determine the distribution of particle size and zeta potential of PNPs. The cytotoxicity property of the nanoparticles was evaluated by MTT assay on MCF-7 and HepG-2 cell lines, and the cytotoxic concentration 50% values were determined for 24 h.

Keywords

  • Platinum nanoparticles,
  • Potassium hexachloroplatinate,
  • Chemical reduction,
  • MTT assay,
  • MCF-7,
  • HepG-2
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