10.57647/ijnd.2026.1703.07

Label-free Sensing of Thiamine, Pantothenic Acid and Pyridoxine Hydrosoluble Vitamins Using a Symmetric Photonic Heterostructure Resonator

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  • Hadi Rahimi*1,
  1. Department of Physics, Shab.C., Islamic Azad University, Shabestar, Iran

Received: 2025-11-20

Revised: 2025-12-10

Accepted: 2025-12-19

Published in Issue 2026-07-10

Published Online: 2026-01-02

Copyright (c) 2025 Hadi Rahimi (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Rahimi, H. (2026). Label-free Sensing of Thiamine, Pantothenic Acid and Pyridoxine Hydrosoluble Vitamins Using a Symmetric Photonic Heterostructure Resonator. International Journal of Nano Dimension, 17(3). https://doi.org/10.57647/ijnd.2026.1703.07
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Abstract

This study presents a label-free biosensor based on a symmetric one-dimensional photonic heterostructure resonator for the refractometric detection of three water-soluble B-complex vitamins. By filling the defect cavity with vitamin solutions, the sensor generated distinct resonance shifts proportional to refractive-index changes, enabling precise molecular discrimination. Optimal performance was achieved at a 60° incidence angle under transverse-electric polarization, yielding ultra-high sensitivity (nearly 280 nm/RIU), a sharp resonance quality factor exceeding 2000, and a detection limit as low as 1.21×10⁻³ RIU, accompanied by a figure of merit greater than 800 surpassing conventional 1D photonic crystal biosensors. A strong polarization-dependent response was observed, with transverse-magnetic (TM) mode performance degrading at high angles due to Brewster’s effect, confirming TE polarization as the superior sensing configuration.

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