10.57647/ijnd.2026.1703.05

Silver Oxide and Silver Iodide Nanomaterials Through the Green Synthesis from Acacia Senegal Plant and Biocompatibility Their Use as Anti-liver Cancer Agents

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  • Saad I. Esmail1,
  • Ali Bahari *1,
  1. Department of Physics, Faculty of Science, University of Mazandaran, Babolsar, Iran

Received: 2025-10-08

Revised: 2025-12-02

Accepted: 2025-02-03

Published Online: 2026-01-02

Copyright (c) 2026 Saad I. Esmail, Ali Bahari (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Esmail, S. I., & Bahari , A. (2025). Silver Oxide and Silver Iodide Nanomaterials Through the Green Synthesis from Acacia Senegal Plant and Biocompatibility Their Use as Anti-liver Cancer Agents. International Journal of Nano Dimension, 17(2 (April 2026). https://doi.org/10.57647/ijnd.2026.1703.05
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Abstract

Silver iodide (AgI) can be obtained from Acacia Senegal and has the potential to inhibit cancer growth. The present investigation using relevant techniques, can be used for the liver cancer (HePG2) in the cell line treatment with silver oxide (AgO) nano-crystallites. This was achieved by exposing Liver cancer cell (HePG2) and healthy cells (WRL68) to 25,50,100,200, and 400 μg/mL concentrations of AgO. The novelty of the present study is comparison of the two types of cells: the (HePG2) and (WRL68) to the (AgI) from A. Senegal plant, which to our knowledge has not been reported. We also used the IC50 assay, which is a measurement used to describe the effectiveness of a substance in inhibiting or suppressing a specific enzyme or cell activity. The IC50 value represents the concentration of the substance required to inhibit the target biological activity by 50%.the graph in Figure shows an IC50 value of 70 in liver cancer cells, which is a positive result. However, the IC50 value in healthy cells was somewhat low at 193.These are good results because the lower the IC50 value in cancer cells, the better the outcome, and the opposite should be true for healthy cells.

Keywords

  • Anti-liver cancer activities,
  • Green synthesis,
  • Nano crystallites,
  • Silver oxide (AgO),
  • Silver iodide(AgI)
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References

  1. K. Vaishali,M. Nirmala,N. Pavithra,and K. Balakrishnan, “Sol gel synthesis of undoped and Nitrogen doped Titanium Dioxide nanoparticles as nano fertilizer for plant growth.”. Int. J. Nano Dimens. 15 (4): 1524301-8. 2024. DOI:10.57647/j.ijnd.2024.1504.3
  2. B. Azari, A. Pourahmad, B. Sadeghi, M. Mokhtary. “Green synthesis of SiO2 from Equisetnm arvense plant for synthesis of SiO2/ZIF-8 MOF nanocomposite as photocatalyst.”. Journal of Coordination Chemistry, 76(2), 219–231.2023. DOI:10.1080/00958972.2023.216640
  3. M. Oves, M. A. Rauf, M. Aslam, H. A. Qari, H. Sonbol, I. Ahmad, G. S. Zaman, M. Saeed. “Green synthesis of silver nanoparticles by Conocarpuslancifolius plant extract and their antimicrobial and anticancer activities.” Saudi Journal of Biological Sciences, 29(2), 460–471. 2023. DOI:10.1016/j.sjbs.2021.09.007
  4. ] M. F. Al-Hakkani. Biogenic copper nanoparticles and their applications: A review. SN Applied Sciences, 2(3), 505-515. 2020. DOI: 10.1007/s42452-020-2199-4
  5. P. Sutradhar, M. Saha, D.Maiti. “Microwave synthesis of copper oxide nanoparticles using tea leaf and coffee powder extracts and its antibacterial activity.”. Journal of Nanostructure in Chemistry, 4, 86-99. 2014. DOI: 10.1007/s40097-014-0086-0
  6. V. V. Konduri, N. K. Kalagatur, L. Gunti, U. K. Mangamuri, V. R. Kalagadda, S. Poda, S. B. N. Krishna. “Green synthesis of silver nanoparticles from Hibiscus tiliaceus L. leaves and their applications in dye degradation, antioxidant, antimicrobial, and anticancer activities.” South African Journal of Botany. 168, 476–487. 2024. DOI:10.1016/j.sajb.2024.03.03
  7. Y. Wang, and S. Wei. “Green fabrication of bioactive silver nanoparticles using Menthapulegium extract under alkaline conditions: An enhanced anticancer activity.”. ACS Omega. 7(2), 1494–1504. 2022. DOI: 10.1021/acsomega.1c0547
  8. M. Govindappa, S. Tejashree, V. Thanuja, B. Hemashekhar, C. Srinivas, O. Nasif, A. Pugazhendhi, and V. Raghavendra. Pomegranate fruit fleshy pericarp mediated silver nanoparticles possessing antimicrobial, antibiofilm formation, antioxidant, biocompatibility and anticancer activity. Journal of Drug Delivery Science and Technology, 61, 102289-97. 2021.DOI:10.1016/j.jddst.2020.102289
  9. A. M. Alattar. “The influence of pulsed laser on the structural and optical properties of green tea extract leaf produced with silver nanoparticles as antimicrobial.” Journal of Molecular Liquids, 398, 124287. 2024. https://doi.org/10.1016/j.molliq.2024.124287
  10. Y. Mbenga, J. O. Adeyemi, D. M. N. Mthiyane, M. Singh, and D. C. Onwudiwe. “Green synthesis, antioxidant and anticancer activities of TiO2 nanoparticles using aqueous extract of Tulbhagia violacea.”. Results Chem, 6:101007-17. 2023. DOI: 0.1016/j.rechem.2023.101007.
  11. K. S. Y. Al Baloushi, A. Senthilkumar, K. Kandhan, R. Subramanian, J., Kizhakkayil, T. Ramachandran, S., Shehab, S., Kurup, M. Alyafei, A. S. Al Dhaheri, and A. Jaleel. “Green synthesis and characterization of silver nanoparticles using Moringaperegrina and their toxicity on MCF-7 and Caco-2 human cancer cells.”. International Journal of Nanomedicine, 19, 3891–3905.2024. DOI:10.2147/IJN.S451694
  12. D. S. Basavarajappa, R. S. Kumar, A. I. Almansour, B. Chakraborty, M.P. Bhat, S.K. Nagaraja, H. Hiremath, K., Perumal, and S. Nayaka. “Biofunctionalized silver nanoparticles synthesized from Passifloravitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities.” Biochemical Engineering Journal, 182, 108517-27. 2022. DOI:10.1016/j.bej.2022.108517
  13. A. B. Younis, Y. Haddad, L. Kosaristanova, and K. Smerkova. “Titanium dioxide nanoparticles: Recent progress in antimicrobial applications.”. WIREs Nanomedicine Nanobiotechnology, 15:e1860-77.2023. DOI: https://doi.org/10.1002/wnan.1860.
  14. M. Rudrappa, R.S. Kumar, S.K. Nagaraja, H. Hiremath, P.V. Gunagambhire, A.I. Almansour, K. Perumal, and S. Nayaka. “Myco-nanofabrication of silver nanoparticles by Penicilliumbrasilianum NP5 and their antimicrobial, photoprotective and anticancer effect on MDA-MB-231 breast cancer cell line.” Antibiotics, 12(3), 567-276. 2023. DOI:10.3390/antibiotics12030567
  15. L. V. Hublikar, S. V. Ganachari, V. B. Patil, S. Nandi, and A. Honnad. “Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract.”. Progress in Biomaterials, 12(2), 155–169. 2023. DOI:10.1007/s40204-023-00219-9
  16. L. A. T. Nguyen, B. V. Mai, Nguyen, D. V. Thi Nguyen, N. Q. Pham, V. V. Pham,and T. L. M., Le. “Green synthesis of silver nanoparticles using Callisiafragrans leaf extract and its anticancer activity against MCF-7, HepG2, KB, LU-1, and MKN-7 cell lines.”. Green Processing and Synthesis, 12(1), 20230024-34. 2024. DOI:10.1515/gps-2023-0024
  17. A. Bahari, S. I. Esmail, A. M. Alattar. “Investigate optical and structural properties with molecular behavior of AgI and silver oxide nanoparticles prepared by green synthesis from the Acacia Senegal plant and achieving biocompatibility.”. Journal of Optics, 54(3), 1261–1268. 2024. https://doi.org/10.1007/s12596-024-01810-4
  18. D. Shajari, A. Bahari, P. Gill and M. Mohseni, “Synthesis and tuning of gold nanorods with surface plasmon resonance.”. Optical Materials, 64, 376-383. 2017. DOI: 10.1016/j.optmat.2017.01.004
  19. A. Muthuvel, N. M. Said, M. Jothibas, K. Gurushankar, and V. Mohana. “Microwave-assisted green synthesis of nanoscaled titanium oxide: photocatalyst, antibacterial and antioxidant properties.”. Journal of Material Science Material Electronic, 32:23522–23539, 2021. DOI: https://doi.org/10.1007/s10854-021-06840-3.
  20. A. Bahari, S. Ahmady-Asbchin, M. Naeij, A. Farhadikoutenaei, A. Al-Jilef, “Green synthesis and study of structural properties of Copper nanocrystallites from hawthorn plant extract and study of its antibacterial activities.”. Int. J. Nano Dimens. 14 (2): 138-144. 2023. DOI: 10.22034/ijnd.2023.1977078.2199
  21. SM. Feyadh, AH. Mohammed. “Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells”. Mater Res Express. 2022;9:055402 DOI 10.1088/2053-1591/ac6d4b.