Topical medication of Tobramycin drops is more effective than Levofloxacinor drops for bacterial suppurative otitis: a retrospective study

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  • Shoude Zhang1,
  • Mao Jin1,
  • Jun Liu2,
  • Lei Zhang1,
  • Yuan Zhao2,
  • Mang Xiao1,
  • Dan Zhang1,
  • Guojin Zhou1,
  • Ying Lu*3,
  1. Department of Otolaryngology/Head and Neck, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
  2. Department of Otolaryngology/Head and Neck, Aral Hospital, Xinjiang Corps, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Aral 843300, Corps, The Xinjiang Uygur Autonomous Region, China
  3. Department of Otolaryngology/Head and Neck, the First People’s Hospital of Lin’an District, Hangzhou 311300, Zhejiang Province, China

Published in Issue 2023-11-17

How to Cite

Zhang, S., Jin, M., Liu, J., Zhang, L., Zhao, Y., Xiao, M., Zhang, D., Zhou, G., & Lu, Y. (2023). Topical medication of Tobramycin drops is more effective than Levofloxacinor drops for bacterial suppurative otitis: a retrospective study. International Journal of Industrial Chemistry, 13(2). https://oiccpress.com/ijic/article/view/4128

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Abstract

Topical medications of Levofloxacinor drops and Tobramycin drops are common therapies for bacterial suppurative otitis. This study aimed to compare the efficacy of the two treatment methods for this disease by retrospective analysis. Total 289 cases prescribed Levofloxacinor drops (n = 154) or Tobramycin drops (n = 135) in the past five years were respectively selected from two hospitals in Zhejiang Province and Xinjiang Uygur Autonomous Region. The total rate of treatment effectiveness of Tobramycin group is 91.1% while that of Levofloxacinor group is 81.2% (P=0.018). Specifically, in chronic cases, Tobramycin group (84.5%) had higher treatment effectiveness than Levofloxacinor group (65.1%) (P=0.0212). The enrolled cases had lower microbial sensitivity to Levofloxacinor (85.8%) than Tobramycin (92.4%), especially to Staphylococcus aureus (Tobramycin 93.5% versus Levofloxacinor 86.5%). For cases with treatment failure, a second treatment was given. Except for cases with Pseudomonas aeruginosa infection, most cases with Levofloxacin treatment failure could be cured by Tobramycin. Conversely, most cases with Tobramycin treatment failure could not be cured by Levofloxacin. In conclusion, Topical medication of Tobramycin drops might be a better or at least good alternative for the empirical treatment of bacterial suppurative otitis.

Keywords

  • Empirical treatment,
  • Levofloxacinor,
  • Suppurative bacterial otitis,
  • Tobtamycin,
  • Topical antibiotics
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