2,2â-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives

Abstract

In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2â-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. Research Highlights

• 2,2â²-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media.
• Simple procedure, short reaction times, and high yields.
• No column chromatographic separation, commercial availability and recyclability of the catalyst.
• Use of GC-Mass analysis for the confirmation of the proposed mechanism.