Published 2024-07-10
How to Cite
2,2â-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. (2024). Iranian Journal of Catalysis, 14(3). https://doi.org/10.57647/j.ijc.2024.1403.27
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Abstract
In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2â-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. Research Highlights- 2,2â²-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media.
- Simple procedure, short reaction times, and high yields.
- No column chromatographic separation, commercial availability and recyclability of the catalyst.
- Use of GC-Mass analysis for the confirmation of the proposed mechanism.
Keywords
- 2,
- 2â-bipyridine,
- 3-d]pyrimidines,
- One-pot synthesis,
- Organo-catalyst
- Pyrano[2,
- Pyrido[2