10.57647/j.ijc.2024.1403.27

2,2â-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives

  1. Department of Chemistry, College of Science, University of Guilan, Rasht, Iran
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Published 2024-07-10

How to Cite

2,2’-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. (2024). Iranian Journal of Catalysis, 14(3). https://doi.org/10.57647/j.ijc.2024.1403.27

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Abstract

In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2â-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. Research Highlights
  • 2,2â²-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media.
  • Simple procedure, short reaction times, and high yields.
  • No column chromatographic separation, commercial availability and recyclability of the catalyst.
  • Use of GC-Mass analysis for the confirmation of the proposed mechanism.

Keywords

  • 2,
  • 2’-bipyridine,
  • 3-d]pyrimidines,
  • One-pot synthesis,
  • Organo-catalyst,
  • Pyrano[2,
  • Pyrido[2