Synthesis and Application of New Co/Cu/Ni/Zn (II) Schiff base Complexes in the Biological Activity and Oxidation of Alcohols

Abstract

In this research article, the Schiff base ligand 3-((2-amino-4-nitrophenyl) imino) indolin-2-one (Ln) was synthesized through the reaction between indoline 2, 3-dione and 4-nitrobenzene-1, 2-diamine. The synthesized ligand was then characterized using various analytical techniques, including 1HNMR, UV-Vis, FT-IR, and element analysis C.H.N. The presence of nitrogen (N) and oxygen (O) atoms in the ligand structure makes it suitable for coordination chemistry. Furthermore, the ligand was employed for the synthesis of metal ion complexes by reacting it with transition metal salts such as CoCl2.6H2O, NiCl2.6H2O, CuCl2.2H2O, and anhydrous ZnCl2. These metal (II) complexes were subsequently utilized for the oxidation of alcohols in toluene under thermal conditions. To further investigate the properties of the newly prepared complexes [M(Lnn)2]Cl2, various characterization techniques, including FTIR, UV-Vis, magnetic susceptibility, atomic absorption spectroscopy, and molar conductance were employed. Moreover, this study aimed to evaluate the impact of the synthesized ligand and its complexes on the Mitotic Index in human lymphocyte cells. A concentration of 100 μg/mL was utilized, and the exposure time was set at 15 minutes. The results indicated that the ligand had a greater effect on the rate of lymphocyte cell division compared to the complexes. This suggests that the ligand exhibited a stronger resemblance to colchicine in terms of inhibiting lymphocyte division during the equatorial phase.

Research Highlights

• In this research a new ligand Schiff base was synthesized.
• The prepared ligand was three dendate coordinator ligand.
• Ni, Cu, Co, and Zn (II) was coordinated to double ligand to prepare metal (II) complexes.
• The prepared complexes were applied in the oxidation of alcohols.
• The influence of prepared complexes was evaluated on mitotic index in lymphocytes of humans.
• The prepared catalysts were characterized by FT-IR, atomic absorption, elemental analysis, UV-vis, and molar conductance.