Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the construction of N-amino-2-pyridone analogs

Abstract

In this work, an efficient method for the construction of N-amino-2-pyridone analogs was performed using the condensation of aldehyde, malononitrile and cyanoacetohydrazide through Fe3O4@aminopropyltriethoxysilane-terephthaldehyde-melamine (Fe3O4@APTES-TA-MA) as an efficient recyclable magnetic covalent organic framework nanocatalyst in ethanol at reflux conditions. Fe3O4@APTES-TA-MA was characterized via FT-IR, EDS, SEM, TEM, VSM, and TGA methods. The average size of the nanoparticles was found between 40â90 nm. Clean procedure, short reaction time, and high efficiency are some benefits of this protocol. Also, the nanomagnetic catalyst can be reused five times without significant loss of its activity. Highlights:

·      A series of N-amino-2-pyridone analogs were synthesized

·  Fe₃O₄@APTES-TA-MA covalent organic framework prepared and characterized by different spectroscopic techniques.

·       High yields and easy work-up procedure are some advantages of this protocol.

·      The catalyst is easily recycled by magnetic attraction.