10.57647/ijc.2026.1601.04

Iron catalysed decarboxylative oxidation photocatalysis of alpha-carbon to access aldehyde/ketone from aryl aliphatic carboxylic acid

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  • Raunak Katiyar1,
  • Sumit Kumar1,
  • Gopal L. Khatik*1,
  1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli, Uttar Pradesh, India.

Received: 2025-08-18

Revised: 2025-10-15

Accepted: 2025-11-04

Published in Issue 2026-03-31

Published Online: 2025-11-25

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Katiyar, R., Kumar, S., & Khatik, G. L. (2026). Iron catalysed decarboxylative oxidation photocatalysis of alpha-carbon to access aldehyde/ketone from aryl aliphatic carboxylic acid. Iranian Journal of Catalysis, 16(1 (March 2026). https://doi.org/10.57647/ijc.2026.1601.04
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Abstract

Carbonyl-containing compounds, such as aldehydes and ketones, are fundamental to synthetic organic chemistry, with wide-ranging applications in the pharmaceutical industry. In this study, we introduce an efficient and streamlined metallophotoredox approach for decarboxylative oxygenation via visible-light-induced ligand-to-metal charge transfer (LMCT). Our method simplifies the transformation of aryl aliphatic carboxylic acids into their corresponding aryl aldehydes and ketones, utilizing iron(III) triflate as a photo catalyst in the presence of TMEDA as a ligand. This strategy not only enhances environmental sustainability but also expands the potential for late-stage functionalization of complex molecules and bioactive compounds.

Keywords

  • Iron (III) triflate, metallophotoredox, decarboxylative oxygenation, carboxylic acid, aldehyde, ketone
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