10.57647/j.ijc.2025.1504.44

Introduction of a Nanocomposite of NiO/MgO for the Regioselective Synthesis of 1,4 Disubstituted- 1,2,3-Triazoles and Investigation of Antimicrobial Properties

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Supplementary Information
  • Marzieh Babaie1,
  • Jalal Albadi*1,2,
  • Hamzeh Kiyani1,
  • Zahra Hemati3,
  • Maryam Banitalebi1,
  1. Department of Chemistry, College of Science, Shahrekord University, Shahrekord, Iran
  2. Nanotechnology Research Institute, Shahrekord University, Shahrekord, Iran
  3. Department of Phathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

Published in Issue 2025-12-31

Published Online: 2025-11-05

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Babaie, M., Albadi, J., Kiyani, H., Hemati, Z., & Banitalebi, M. (2025). Introduction of a Nanocomposite of NiO/MgO for the Regioselective Synthesis of 1,4 Disubstituted- 1,2,3-Triazoles and Investigation of Antimicrobial Properties. Iranian Journal of Catalysis, 15(04). https://doi.org/10.57647/j.ijc.2025.1504.44
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Abstract

In this research, an eco-friendly procedure is reported for the synthesis of NiO/MgO nanocomposite by the co-precipitation method. The obtained nanocomposite was characterized using FE-SEM, EDS, BET, XRD, and TGA analyses. The catalytic performance of the NiO/MgO nanocomposite was investigated in the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles under mild conditions. The results revealed that the desired triazole derivatives were produced in high yields with excellent selectivity. The catalyst exhibited notable stability and recyclability over several cycles without significant loss of activity. In addition, the antibacterial activity of the NiO/MgO nanocomposite was evaluated against various bacterial strains, showing good inhibitory effects against the tested pathogens.

Keywords

  • Antibacterial properties, 1,4-disubstituted-1,2,3-triazoles, Eco-friendly procedure, NiO/MgO nanocomposite, Regioselective synthesis.
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References

  1. C.W. Tornøe, C. Christensen, M. Meldal, J. Org. Chem. 67 (2002) 3057-3064. doi: 10.1021/jo011148j.
  2. Z.J. Wang, Y. Gao, Y.L. Hou, C. Zhang, S.J. Yu, Q. Bian, Z.M. Li, W.G. Zhao, Eur. J. Med. Chem. 86 (2014) 87-94. doi: 10.1016/j.ejmech.2014.08.029.
  3. T. Lee, M. Cho, S.Y. Ko, H.J. Youn, D.J. Baek, W.J. Cho, C.Y. Kang, S. Kim, J. Med. Chem. 50 (2007) 585-589. doi: 10.1021/jm061243q.
  4. S. Shaik, P. Nuthalapati, G.R. Venkat, S. Reddymasu, et al., Lett. Org. Chem. 17 (2020) 864-871. doi: 10.2174/1570178617666200225102939.
  5. V.V. Rostovtsev, L.G. Green, et al. Chem. Int. Ed. 41 (2002) 2596-2599. doi: 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4.
  6. M. Thakur, P. Chaudhary, A. Kejriwal, A. Mukherjee, K. Biswas, Inorg. Chim. Acta. 549 (2023) 121405. doi: 10.1016/j.ica.2023.121405.
  7. M. Rajabi, J. Albadi. A.R. Momeni, Res. Chem. Intermed. 46 (2020) 3879-3889. doi: 10.1007/s11164-020-04178-9.
  8. N. Kaviani, S, Behrouz, A.A. Jafari, M.N. Soltani Rad, J. Organomet. Chem. 1007 (2024) 123043. doi: 10.1016/j.jorganchem.2024.123043.
  9. P. Kalita, P.P. Sarma, P. Dutta, U.K. Gautam, P.K. Baruah, Polycycl. Aromat. Compd. 43 (2023) 5338-5353. doi: 10.1080/10406638.2022.2101485.
  10. M. Bakherad, A. Keivanloo, A. H. Amin, P. Ghamari Kargar, Iran. J. Catal. 8 (2018) 179-187. doi: 10.1007/s13738-018-1468-y.
  11. F.B. Souza, D.C. Pimenta, H.A. Stefani, Tetrahedron Lett. 57 (2016) 1592-1596. doi: 10.1016/j.tetlet.2016.02.105.
  12. S.S. Saei Dehkordi, A.A. Jafari, J. Albadi, H.A. Samimi, Mol. Divers. 27 (2023) 177-192. doi: 10.1007/s11030-022-10408-6.
  13. C. Sharma, M. Kaur, A. Choudhary, S. Sharma, S. Paul, Catal. Lett. 150 (2020) 82-94. doi: 10.1007/s10562-019-02936-y.
  14. S.J. Kwak, U.S. Shin, S.H. Kim, J. Chem. Sci. 135 (2023) 10. doi: 10.1007/s12039-023-02132-x.
  15. A.R. Sardarian, F. Abbasi, M. Esmaeilpour, Sustain. Chem. Pharm. 36 (2023) 101256. doi: 10.1016/j.scp.2023.101256.
  16. M. Thakur, P. Choudhury, A. Kejriwal, A. Mukherjee, K. Biswas, Inorg Chim Acta 549 (2023) 121405. doi: 10.1016/j.ica.2023.121405.
  17. D. Hosseipour, J. Albadi, H.A. Samimi, Z. Hemati, F. Alidousti, Res. Chem. Intermed. 50 (2024) 2015-2030. doi: 10.1007/s11164-024-05266-w.
  18. A. Khoshnoud, A.R. Pourali, Org. Prep. Proced. Int. 53 (2021) 509-517. doi: 10.1080/00304948.2021.1971475.
  19. A. Kakavand Ghalenoei, M. Bakherad, A. Keivanloo, Iran. J. Catal. 9 (2019) 293-303. doi: 10.1002/slct.201901655.
  20. Y.M.A. Mohamed, S.H. Abdel-Hafez, H. Elsayed, M. Taha, Y.A. Attia, Chem. Pap. 78 (2024) 7865-7876. doi:10.1007/s11696-024-03640-x
  21. A. Kumar, V. Sharma, M. Bhardwaj, S. Maji J. Inorg. Organomet. Polym. (2025). https://doi.org/10.1007/s10904-024-03526-1
  22. N. Kaur, P. Grewal, P. Bhardwaj, M. Devi, N. Ahlawat, Y. Verma, Synth, Commun, 49 (2019) 3058-3100. doi: 10.1080/00397911.2019.1655767.
  23. H.S.P. Rao, G. Chakibanda, RSC. Adv. 4 (2014) 46040-46048. doi: 10.1039/C4RA07057G.
  24. Z. Hashemi, J. Albadi, M. Jalali, Res. Chem. Intermed. 47 (2021) 5291-5302. doi: 10.1007/s11164-021-04569-6.
  25. P. Choudhury, S. Chattopadhyay, G. De, B. Basu, Adv. Mater. 2 (2021) 3042-3050. doi: 10.1039/D1MA00143D.
  26. R. Mirzakhani, J. Albadi, H.A. Samimi. Z. Hemmati, F. Alidousti, Chem. Africa. 7 (2024) 3821-3830. doi: 10.1007/s42250-024-01019-9.
  27. A. Yousofvand, M. Amini, M. Hosseinifard, A. Bayrami, J. Janczak, Polyhedron. 258 (2024) 117041. doi: 10.1016/j.poly.2024.117041.
  28. N.A. Alarfaj, M.F. El-Tohamy, Polym. 12 (2020) 3066. doi: 10.3390/polym12123066.
  29. M. Jafarbegloo, A. Tarlani, A. Wahid Mesbah, S. Sahebdelfar, J. Nat. Gas Sci. Eng. 27 (2015) 1165-1173. doi: 10.1016/j.jngse.2015.09.065.