10.57647/j.ijc.2025.1503.33

Efficient and greener method synthesis of pyrano [2, 3-c] pyrazole derivatives catalyzed by Fe3O4@L-Cys-SH as reusable catalyst

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  • Raju Shekhanavar1,
  • Santosh Y. Khatavi2,
  • Kantharaju Kamanna*1,
  1. Rani Channamma University, Belagavi, P-B, NH-4-591156, Karnataka. India
  2. Department of Chemistry, Rani Channamma University, Belagavi, P-B, NH-4-591156, Karnataka, India
Efficient and greener method synthesis of pyrano [2, 3-c] pyrazole derivatives catalyzed by Fe3O4@L-Cys-SH as reusable catalyst

Received: 2025-03-04

Revised: 2025-05-16

Accepted: 2025-06-06

Published in Issue 2025-09-30

Published Online: 2025-07-01

Copyright (c) 2025 Raju Shekhanavar, Santosh Y. Khatavi, Kantharaju Kamanna (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Shekhanavar, R., Khatavi, S. Y., & Kamanna, K. (2025). Efficient and greener method synthesis of pyrano [2, 3-c] pyrazole derivatives catalyzed by Fe3O4@L-Cys-SH as reusable catalyst. Iranian Journal of Catalysis, 15(3 (September 2025). https://doi.org/10.57647/j.ijc.2025.1503.33
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Abstract

The present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4 (MNPs), and further functionalized with L-Cysteine amino acid. Various analytical and spectroscopic techniques used for the characterization of prepared MNPs and its functionalized materials. Further demonstrated utility of this functionalized MNPs for four component one-pot synthesis of pyrano [2, 3-c]pyrazole derivatives. The synthetic approach outlined is rapid, eco-friendly, and allows for the simple isolation of the product. After recrystallization of the crude product gave a chromatographically pure product, this method found an inexpensive and recyclable catalyst, which was achieved up to four cycles for the synthesis of bioactive heterocycles. The synthesized derivatives were characterized using FT-IR, 1H- & 13C-NMR, and LC-MS. Additionally, some of the selected derivatives showed moderate antioxidant activity (5a, five h, 5i, 5j, 5k, 5n, 5p, and 5q) against a reference.

Keywords

  • Antioxidant,
  • Eco-friendly,
  • Functionalized,
  • Pyrano [2,3-c] pyrazole,
  • Recyclable
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