10.57647/ijbbe.2025.0601.01

Restoration of Exosomal miR-125b, lncRNA TUG1 and lncRNA NEAT1 Homeostasis by Vitamin D in Polycystic Ovary Syndrome: Insights from an Experimental Rat Study

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  • Fatemeh Attarian1,
  • Jina Khayatzadeh*1,
  • Mohammad Mahdi Forghanifard2,
  • Saeedeh Zafar Balanezhad1,
  1. Department of Biology, Ma.C., Islamic Azad University, Mashhad, Iran
  2. Department of Biology, Da.C., Islamic Azad University, Damghan, Iran

Received: 2025-12-03

Revised: 2026-02-25

Accepted: 2026-01-26

Published in Issue 2026-06-30

Copyright (c) 2026 Fatemeh Attarian, Jina Khayatzadeh, Mohammad Mahdi Forghanifard, Saeedeh Zafar Balanezhad (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Attarian, F., Khayatzadeh, J., Forghanifard, M. M., & Balanezhad, S. Z. (2026). Restoration of Exosomal miR-125b, lncRNA TUG1 and lncRNA NEAT1 Homeostasis by Vitamin D in Polycystic Ovary Syndrome: Insights from an Experimental Rat Study. International Journal of Biophotonics and Biomedical Engineering (IJBBE), 6(1). https://doi.org/10.57647/ijbbe.2025.0601.01
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Abstract

Polycystic ovary syndrome (PCOS) is a disease of ovarian dysfunction, hyperandrogenism and metabolic disorders in which exosomal noncoding RNAs have been reported to play a key role in its development. Vit-D (Vit-D) is known to modulate ovarian and systemic metabolism, but the impact of Vit-D on exosomal RNA networks has not been well studied. Thus, this work evaluated the regulatory role of Vit-D supplementation on exosomal microRNA (miR-125b) and long non-coding RNAs (Lnc-TUG1, Lnc-NEAT1) in PCOS rat model, offering potential mechanisms by which dietary intervention influences molecular regulation.

Keywords

  • Vit-D,
  • PCOS,
  • Exosomes,
  • miRNA,
  • LncRNAs,
  • Precision Therapy
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