OICC Press International Journal of Biophotonics and Biomedical Engineering (IJBBE) 2980-9037 6 1 2026 06 30 Restoration of Exosomal miR-125b, lncRNA TUG1 and lncRNA NEAT1 Homeostasis by Vitamin D in Polycystic Ovary Syndrome: Insights from an Experimental Rat Study 10.57647/ijbbe.2025.0601.01 EN Fatemeh Attarian Department of Biology, Ma.C., Islamic Azad University, Mashhad, Iran Jina Khayatzadeh Department of Biology, Ma.C., Islamic Azad University, Mashhad, Iran Mohammad Mahdi Forghanifard Department of Biology, Da.C., Islamic Azad University, Damghan, Iran Saeedeh Zafar Balanezhad Department of Biology, Ma.C., Islamic Azad University, Mashhad, Iran Journal Article 2026 06 30 Polycystic ovary syndrome (PCOS) is a disease of ovarian dysfunction, hyperandrogenism and metabolic disorders in which exosomal noncoding RNAs have been reported to play a key role in its development. Vit-D (Vit-D) is known to modulate ovarian and systemic metabolism, but the impact of Vit-D on exosomal RNA networks has not been well studied. Thus, this work evaluated the regulatory role of Vit-D supplementation on exosomal microRNA (miR-125b) and long non-coding RNAs (Lnc-TUG1, Lnc-NEAT1) in PCOS rat model, offering potential mechanisms by which dietary intervention influences molecular regulation.