Novel and cost-effective biocatalyst consisting of nanofibrillated cellulose and TiCl3 for the synthesis of 2,3′-dihydroquinazolin-4-(1H)-ones

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  • Hannaneh Heidari1,
  • Kobra Nikoofar*2,
  • Yeganeh Shahedi1,
  1. Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University. P.O. Box 1993893973, Tehran, Iran.
  2. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran

Published in Issue 2024-02-25

How to Cite

Heidari, H., Nikoofar, K., & Shahedi, Y. (2024). Novel and cost-effective biocatalyst consisting of nanofibrillated cellulose and TiCl3 for the synthesis of 2,3′-dihydroquinazolin-4-(1H)-ones. Iranian Journal of Catalysis, 9(1). http://oiccpress.com/ijc/article/view/4026

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Abstract

A novel and cost-effective catalyst for synthesis of 2,3'-dihydroquinazolin-4-(1H)-ones was developed utilizing a combined nanocomposite obtained from bonding TiCl3 to hydroxyl groups of nanofibrillated cellulose as a green and inexpensive support.The structure of the catalyst was investigated using the Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) techniques and transmission electron microscopy (TEM). The prepared new nanopolymer-based composite has been investigated successfully to obtain some 2,3'-dihydroquinazolin-4-(1H)-ones via the reaction of 2-aminobenzamide and various kinds of aldehydes/ cyclic ketones in refluxing ethanol. Short reaction times, the low amount of catalyst, high yields of products, utilizing a wide-range of aldehydes/ ketones, easy work-up procedure, in addition to the accelerating effect of the newly synthesized biodegradable nano composite, are some highlighted features of the reported protocol.

Keywords

  • 3'-Dihydroquinazolin-4-(1H)-ones,
  • Heterogeneous catalyst,
  • Nanofibrillated cellulose,
  • Titanium chloride
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