High surface area SnO2 nanoparticles as a benign catalyst for the synthesis of 1,5-benzodiazepines

Abstract

A benign and efficient promoted synthesis of 1,5-benzodiazepinederivatives via a simple and atom-economical reaction between 1,2-phenylenediamines as well as ketones by the usage of catalytic amount of SnO₂ nanoparticlesat room temperature in ethanol as a solvent is described. This approach results for the synthesis of various 1,5-benzodiazepines in excellent yields (93-98%). The advantages of this process are operational effortlessness, high yields products, mild reaction conditions, catalyst recyclability, high purity products and short reaction times.