10.30495/ijbbe.2023.699380

Investigation of the Nonlinear Refractive Index of MCF7 and MCF10A Breast Cell Lines for Optical Diagnosis

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  • Bahareh Khaksar Jalali*1,
  • Somayeh Salmani Shik2,
  • Latifeh Karimzadeh Bardee3,
  • sharifeh shahi4,
  1. 1. Department of physics, Kharazmi University, Tehran, Iran 2. Laser and Biophotonics in Biotechnologies Research Center, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran
  2. 1. Department of physics, Kharazmi University, Tehran, Iran 2. Applied Sciences Research Center, Kharazmi University, Karaj, Iran
  3. Department of animal biology, Faculty of biological sciences, kharazmi university, Tehran, Iran
  4. 1. Department of Biomedical Engineering, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran 2. Laser and Biophotonics in Biotechnologies Research Center, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran

Received: 2022-10-12

Accepted: 2023-01-31

Published in Issue 2022-10-01

Copyright (c) 2024 International Journal of Biophotonics and Biomedical Engineering

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Khaksar Jalali, B., Salmani Shik, S., Karimzadeh Bardee, L., & shahi, sharifeh. (2022). Investigation of the Nonlinear Refractive Index of MCF7 and MCF10A Breast Cell Lines for Optical Diagnosis. International Journal of Biophotonics and Biomedical Engineering (IJBBE), 2(1), 41-50. https://doi.org/10.30495/ijbbe.2023.699380
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Abstract

To demonstrate that the Z-scan technique is a reliable approach for diagnosing normal and cancer cells, the absorption coefficient (α), nonlinear refractive index (n2) of normal (MCF10A) and cancer cell lines (MCF7) were examined. According to our findings of the optical properties of cells, cancer cells shown to have higher linear absorption coefficient than normal cells as well as nonlinear refractive index (n2) of different signs but the same order of (10-7 cm2/W). This method is a quick method for differentiating between normal and cancerous breast cells, making it suitable for use in clinical stages in the future. This is because of the obvious fundamental difference between the optical behavior of normal and cancer cells, as well as the affordability, the potential for reproducibility without compromising sample quality, and the high accuracy.

Keywords

  • Cancer Diagnosis,
  • Linear Absorption,
  • MCF7,
  • MCF10A,
  • Optical Coefficients,
  • Z-scan Technique
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