Development of Deep Convolutional Neural Network Algorithms Based on DenseNet Model for Adaptive Classification of Chest Diseases
- Department of Biomedical Engineering, The Federal University of Technology, Akure, Ondo State, Nigeria
- Biomedical Engineering Unit, Federal Medical Centre, Ebute-Meta, Lagos State, Nigeria
Received: 2025-05-23
Revised: 2025-09-21
Accepted: 2025-10-29
Published in Issue 2025-12-30
Copyright (c) 2025 Vincent Andrew Akpan, Miss Naheemat O. Olayemi (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.
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Abstract
Chest diseases pose serious health threats if not detected early for properly and timely diagnosis. These diseases could include pulmonary disease, pneumonia, asthma, tuberculosis, lung diseases and other cardiovascular complications. When patients exhibit symptoms like chest pain, shortness of breath, or persistent cough; physicians often prescribe chest X-rays to assess the underlying cause of their discomfort. Chest X-ray is a commonly used diagnostic imaging test that requires significant expertise and careful observation to classify the particular or multiple chest diseases due to the complex nature of the pathology and fine texture of lung lesions. Chest X-Ray classification is a challenging and time consuming task in medical image classification due to the complexity of the human chest structure and the subtle variations in X-Ray images caused by different medical conditions. This paper presents a novel classification technique for the classification of 14 chest diseases that could impair patient’s health. The classification technique presented in this paper is a deep convolutional neural network (CNN) algorithms based on DenseNet model structure for adaptive classification of chest diseases. This paper address and bridges three main research gaps in chest diseases classification, namely: 1). enhancing the classification accuracy and specificity in diagnosing up to 14 different classes of chest diseases based on label distributions; 2). develops an AI-based deep learning CNN using DenseNet model structure to accurately classify and predict the risk probability levels of heart failures based on chest X-ray images; and 3). the research leverages the issues of interpretability and explainability as the results is self-explanatory to clinicians. The results demonstrate the efficiency, proficiency and robustness of the deep CNN algorithm based on DenseNet model structure. The paper concludes with a comprehensive discussion on the model’s performance, shedding lights on its strengths and potential areas for improvement. The technique presented in this paper can easily be adapted for real-time chest diseases classification by clinicians.
References
- H. Malik, T. Anees, M. Din and A. Naeem, “CDC_Net: multi-classification convolutional neural network model for detection of COVID-19, pneumothorax, pneumonia, lung Cancer, and tuberculosis using chest X-rays,” Multimedia Tools and Applications, Vol. 82, pp. 13855 – 13880, 2023. Available: https://doi.org/10.1007/s11042-022-13843-7.
- J. O. Olayiwola, J. A. Badejo, K. Okokpujie and M. E. Awomoyi, “Lung-Related Diseases Classification Using Deep Convolutional Neural Network,” Mathematical Modelling of Engineering Problems, Vol. 10, No. 4, pp. 1097 – 1104, 2023.
- E. Çallı, E. Sogancioglu, B. van Ginneken, K. G. van Leeuwen and K. Murphy, “Deep learning for chest X-ray analysis: A survey,” In Medical Image Analysis, Vol. 72, 2021. Elsevier B.V., London. Available: https://doi.org/10.1016/j.media.2021.102125.
- T. N. Muhammad, T. Hussain, C. S. Lee and M. A. Khan, “Classification and Detection of COVID-19 and Other Chest-Related Diseases Using Transfer Learning,” Sensors, Vol. 22, No. 7977, pp. 1 – 18, 2022. Available: https://doi.org/10.3390/s22207977.
- A. Ghosh, A. Sufian, F. Sultana, A. Chakrabarti and D. De, “Fundamental Concepts of Convolutional Neural Network,” In: Balas, V., Kumar, R., Srivastava, R. (eds) Recent Trends and Advances in Artificial Intelligence and Internet of Things. Intelligent Systems Reference Library, Vol. 172, pp. 516 – 567, 2020. Springer, Cham., Available: https://doi.org/10.1007/978-3-030-32644-9_36.
- M. Krichen, “Convolutional Neural Networks: A Survey,” Computers, Vol. 12, No. 151, pp. 1 – 41, 2023. Available: https://doi.org/10.3390/computers12080151.
- I. D. Mienye, T. G. Swart, G. Obaido, M. Jordan and P. Ilono, “Deep Convolutional Neural Networks: A Comprehensive Review,” Technical Report, Institute of Intelligent Systems, University of Johannesburg, Johannesburg, Gauteng, South Africa, pp. 1 – 34, 2024. Available: doi: 10.20944/preprints202408.1288.v1.
- R. Khanam, M. Hussain, R. Hill and P. Allen, “A Comprehensive Review of Convolutional Neural Networks for Defect Detection in Industrial Applications,” IEEE Access, Vol. 4, pp. 1 – 47, 2016. Available: DOI 10.1109/ACCESS.2024.3425166.
- R. Miotto, F. Wang, S. Wang, X. Jiang and J. T. Dudley, “Deep learning for healthcare: Review, opportunities and challenges,” Briefings in Bioinformatics, Vol. 19, No. 6, pp. 1236 – 1246, 2017. Available: https://doi.org/10.1093/bib/bbx044.
- S. F. Abbasi, Q. H. Abbasi, F. Saeed and N. S. Alghamdi, “A convolutional neural network-based decision support system for neonatal quiet sleep detection,” Mathematical Biosciences and Engineering, Vol. 20, No. 9, pp. 17018 – 17036, 2023. doi: 10.3934/mbe.2023759.
- M. H. Beale, M. T. Hagan and H. B. Demuth, “Deep Learning Toolbox: User’s Guide,” MATLAB & Simulink® 2025, pp. 1 – 5258, 2025. The MathWorks Inc, Natick, U.S.A. www.mathworksa.com.
- MathWorks. MATLAB & Simulink® 2025, The MathWorks Inc, Natick, U.S.A. www.mathworksa.com.
- M. Pal, S. Parija and G. Panda, “An effective ensemble approach for classification of chest X-ray images having symptoms of COVID: A precautionary measure for the COVID-19 subvariants,” e-Prime – Advances in Electrical Engineering, Electronics and Energy, Vol. 8, No. 100547, pp. 1 – 17, 2024.
- J. Du and J. Yang, “Classification of Chest X-ray Images(Pneumonia) Based on ResNet and Grad-CAM,” SPML’ 23: In Proceedings of the 2023 6th International Conference on Signal Processing and Machine Learning, pp. Pages 156 – 164, 2023. Avilable: https://doi.org/10.1145/3614008.3614031.
- A. Karna, A. Jha, A. Dahal, A. Pandey and T. N. Jha, “Chest X-Ray Classification using DenseNet’” In Proceedings of the 13th IOE Graduate Conference, Dharan, Vol. 13, pp. 64 – 67, 2023.
- R. Kundu, R. Das, Z. W. Geem, G. T. Han and R. Sarkar, “Pneumonia detection in chest X-ray images using an ensemble of deep learning models,” PLOS ONE, Vol. 16, No. 9, pp. 1 – 29, 2021. Available: DOI: 10.1371/journal.pone.0256630.
- A. Anushya and P. L. T. Thai, “Classification of Chest Disease Detection Using X-Ray Images through the Implantation of Efficientnetv2,” International Journal of Scientific Research in Engineering and Management, Vol. 8, No. 11, pp. 1 – 10, 2024.
- A. A. Nasser and M. A. Akhloufi, “Chest Diseases Classification Using CXR and Deep Ensemble Learning,” In CBMI’22: In Proceedings of the 19th International Conference on Content-based Multimedia Indexing, New York, U.S.A. pp. 116 – 120, 2022. Available: https://doi.org/10.1145/3549555.3549581.
- O. Saha, J. Tasnim, M. T. Raihan, T. Mahmud, I. Ahmmed and S. A. Anowarul, “A Multi-Model Based Ensembling Approach to Detect COVID-19 from Chest X-Ray Images,” In 2020 IEEE Region 10 Conference (TENCON), Osaka, Japan. pp. 591 – 595, 2020. Available: doi: 10.1109/TENCON50793.2020.9293802.
- Y. X. Tang, Y. B. Tang, Y. Peng, K. Yan, M. Bagheri, B. A. Redd, C. J. Brandon, Z. Lu, M. Han, J. Xiao and R. M. Summer, “Automated abnormality classification of chest radiographs using deep convolutional neural networks,” Digital Medicine, Vol. 3, No. 70, pp. 1 – 8, 2020. Available: doi: https://doi.org/10.1038/s41746-020-0273-z.
- A. A. Nasser and M. A. Akhloufi, “A Review of Recent Advances in Deep Learning Models for Chest Disease Detection Using Radiography,” Diagnosis, Vol. 13, No. 159, pp. 1 – 36, 2023. Available: doi: https://doi.org/10.3390/diagnostics13010159.
- L. Cardinale, G. Volpicelli, A. Lamorte, J. Martino and A. Veltri, ”Revisiting signs, strengths and weaknesses of Standard Chest Radiography in patients of Acute Dyspnea in the Emergency Department,” Journal of Thoracic Disease, Vol. 4, No. 4, pp. 398 – 407, 2012. Available: https://doi.org/10.3978/j.issn.2072-1439.2012.05.05.
- R. Long, A. Lau, J. Barrie, C. Winter, G. Armstrong, M. L. Egedahl and A. Doroshenko, “Limitations of Chest Radiography in Diagnosing Subclinical Pulmonary Tuberculosis in Canada,” Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol. 7, No. 3, pp. 165 – 170., 2023 Available: https://doi.org/10.1016/j.mayocpiqo.2023.03.003.
- S. Iqbal, A. N. Qureshi, M. Alhussein, K. Aurangzeb. and M. S. Anwar, “AD-CAM: Enhancing interpretability of conventional neural networks with a lightweight framework – From black box to glass box,” IEEE Journal of Biomedical and Health Informatics, Vol. 28, No. 1, pp. 514 – 525, 2023.
- L. Mayats-Alpay, “Artificial Intelligence for Automatic Detection and Classification Disease on the X-Ray Images,” Image and Video Processing (EESS.IV), pp. 1 – 21, 2023. Available: http://arxiv.org/abs/2211.08244.
- T. R. Pant, R. K. Aryal, T. Panthi, M. Maharjan and B. Joshi, “Disease Classification of Chest X-Ray using CNN,” In 2021 IEEE 6th International Conference on Computing, Communication and Automation (ICCCA), Arad, Romania, 2021, pp. 467 – 471, 2021. Available: doi: 10.1109/ICCCA52192.2021.9666246.
- R. M. Summer, “NIH Clinical Center provides one of the largest publicly available chest x-ray datasets to scientific community,” Images are available via Box: https://nihcc.app.box.com/v/ChestXray-NIHCC. Retreived 15th January, 2025. Available: https://www.nih.gov/news-events/news-releases/nih-clinical-center-provides-one-largest-publicly-available-chest-x-ray-datasets-scientific-community.
- X. Wang, Y. Peng, L. Lu, Z. Lu, M. Bagheri and R. M. Summers, “ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases,” IEEE CVPR 2017, pp. 1 – 10, 2017. Available: https://openaccess.thecvf.com/content_cvpr_2017/papers/Wang_ChestX-ray8_Hospital-Scale_Chest_CVPR_2017_paper.pdf.
- P. Carter, J. Lagan, C. Fortune, D. L. Bhatt, J. Vestbo, R. Niven, N. Chaudhuri, E. B. Schelbert, R. Potluri and C. A. Miller, “Association of Cardiovascular Disease With Respiratory Disease,” Journal of the American College of Cardiology, Vol. 73, No. 17, pp. 2166 – 2177, 2019. Available: https://doi.org/10.1016/j.jacc.2018.11.063.
- R. A. O. Osakwe, V. A. Akpan and M. T. Babalola, “Comparative Study of the Symptoms of Impending Human Heart, Kidney and Liver Failures Based on Blood Samples,” International Journal of Chinese Medicine (IJCM), Vol. 1, No. 1, pp. 32 – 44, 2017. Available: http://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170102.11.pdf.
- V. A. Akpan, O. T. Omotehinwa and J. B. Agbogun, “Adaptive Classification of Impending Human Heart, Kidney and Liver Failures Based on Measurable Blood-Related Parameters Using MIMO HANFA-ART with ACA Algorithms,” Biomedical Sciences, Vol. 8, No. 3, pp. 97 – 112, 2022. Available: https://www.sciencepg.com/journal/paperinfo?journalid=362&doi=10.11648/j.bs.20220803.14.
- S. M. Kavitha, S. Thaarani, A. P. Singh and G. Santhosh, “Chest Disease Classification Using Convolutional Neural Networks,” In 2023 International Conference on Computer Communication and Informatics (ICCCI), Coimbatore, India. pp. 1 – 4, 2023. doi: 10.1109/ICCCI56745.2023.10128179.
- Y. Hadhoud, T. Mekhaznia, A. Bennour, M. Amroune, N. A. Kurdi, A. H. Aborujilah and M. Al-Sarem, “From Binary to Multi-Class Classification: A Two-Step Hybrid CNN-ViT Model for Chest Disease Classification Based on X-Ray Images,” Diagnostics, Vol. 14, No. 23, pp. 2754, 2024. Available: https://doi.org/10.3390/diagnostics14232754.
- R. S. Koskela, P. Mutanen, J. A. Sorsa and M. Klockars, “Respiratory disease and cardiovascular morbidity,” Occupational and Environmental Medicine, Vol. 62, No. 9, pp. 650 – 655, 2005. Available: https://doi.org/10.1136/oem.2004.017111.
- AHA Electrocadiogram (ECG or EKG). American Heart Association, https://www.heart.org/en/health-topics/diagnosing-a-heart/electrocardiogram-ecg-or-ekg. Retrieved 12th February, 2025. Available [Online]: https://my.clevelandclinic.org/health/diagnostics/16953-electrocardiogram-ekg.
- S. Iqbal, A. N. Qureshi, J. Li, I. A. Choudhry and T. Mahmood, “Dynamic learning for imbalance data in learning chest X-ray and CT images,” Heliyon, Vol. 9, No. 1, pp. 1 – 20, 2023. Available: https://doi.org/10.1016/j.heliyon.2023.e16807.
- R. H. Abiyev and M. K. S. Ma’aitah, “Deep convolutional neural networks for chest disease detection,” Journal of Healthcare Engineering, Vol. 2018, No. 4168538, pp. 1 – 11, 2018. https://doi.org/10.1155/2018/4168538.
- K. Almezhghwi, S. Serte and F. Al-Turjman, “Convolutional neural networks for the classification of chest X-rays in the IoT era,” Multimedia Tools and Applications, Vol. 2021, No. 80, pp. 29051 – 29065, 2021. https://doi.org/10.1007/s11042-021-10907-y.
- D. Lent-Schochet and I. Jialal, “Physiology, Edema,” Treasure Island (FL), StatPearls Publishing, Florida, U.S.A., 2023. Available: https://www.ncbi.nlm.nih.gov/books/NBK537065/.
- S. Saifullah, B. Yuwono, H. C. Rustamaji, B. Saputra, F. A. Dwiyanto and R. Drezewski, “Detection of Chest X-ray Abnormalities Using CNN Based on Hyperparameter Optimization,” In Proceedings of the 4th International Electronic Conference on Applied Sciences Session Computing and Artificial Intelligence, Italy, Vol. 52, pp. 1 – 8, 2023. Available: DOI: 10.3390/ASEC2023-16260.
- C. T. Yen and C. Y. Tsao, “Lightweight convolutional neural network for chest X-ray images classification,” Nature: Scientific Reports, Vol. 14, No. 29759, pp. 1 – 23, 2024. Available: https://doi.org/10.1038/s41598-024-80826-z.
- H. Amin and W. J. Siddiqui, “Cardiomegaly” Treasure Island, StatPearls Publishing, U.S.A., 2023 Available: https://www.ncbi.nlm.nih.gov/books/NBK542296/.
- W. MacNee, ”Pathology, pathogenesis, and pathophysiology,” BMJ, Vol. 332, No. 7551, pp. 12024, 2006.
- V. S. Karkhanis and J. M. Joshi, “Pleural effusion: diagnosis, treatment, and management,” Open Access Emergency Medicine. Vol. 4, pp. 31 – 52, 2012. Availble: doi: 10.2147/OAEM.S29942.
- F. Sabrina, “Understanding Hernias: the Basics,” Last updated 23rd December, 2022. Retrieved 17 February, 2025. Available: https://www.webmd.com/digestive-disorders/understanding-hernia-basics.
- M. A. Miller and J. F. Zachary, “Mechanisms and Morphology of Cellular Injury, Adaptation, and Death,” Pathologic Basis of Veterinary Disease, Vol. 2017, pp. 2 – 43, 2017. Available: doi: 10.1016/B978-0-323-35775-3.00001-1.
- M. P. Kim and W. L. Hofstetter, “Tumors of the diaphragm,” Thoracic Surgery Clinics, Vol. 19, No. 4, pp. 521 – 529, 2009. Available: DOI:10.1016/j.thorsurg.2009.08.007 https://www.researchgate.net/publication/41187480_Tumors_of_the_Diaphragm
- M. K. Gould, J. Donington, W. R. Lynch, P. J. Mazzone, D. E. Midthun, D. P. Naidich and R. S. Wiener, “Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer,” 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, May 2013, Vol. 143, No. 5, pp. e93S – e120S, 2013. doi: 10.1378/chest.12-2351.
- K. Grott, S. Chauhan and J. D. Dunlap, “Atelectasis,” Treasure Island, StatPearls Publishing, Florida, U.S.A., 2023. Available: https://www.ncbi.nlm.nih.gov/books/NBK545316/
- C. L. McKnight and B. Burns, “Pneumothorax,” Treasure Island (FL), StatPearls Publishing, Florida, U.S.A., 2023. Available: https://www.ncbi.nlm.nih.gov/books/NBK441885/.
- P. Pahal, V. Rajasurya and S. Sharma, “Typical Bacterial Pneumonia,” Treasure Island (FL), StatPearls Publishing, Florida, U.S.A., 2023. Available: https://www.ncbi.nlm.nih.gov/books/NBK534295/.
- T. A. Wynn and T. R. Ramalingam, “Mechanisms of fibrosis: therapeutic translation for fibrotic disease,” Natural Medicine, Vol. 18, No. 7, pp. 1028 – 1040, 2012. Available: doi: 10.1038/nm.2807.
- J. Ahuja, G. S. Shroff , Y. Mawlawi and M. T. Truong, “Chronic Airspace Diseases,” Semin Ultrasound CTMR, Vol. 40, No. 3, pp. 175 – 186, 2019. doi: 10.1053/j.sult.2018.11.001.
- A. Rehman, A. Khan, G. Fatima, S. Naz and I. Razzak, “Review on chest pathogies detection systems using deep learning techniques,” Artificial Intelligence Review, Vol. 56, No. 11, pp. 12607–12653, 2023. Available: https://doi.org/10.1007/s10462-023-10457-9.
- C. M. Jones, Q. D. Buchlak, L. Oakden-Rayner, M. Milne, J. Seah, N. Esmaili and B. Hachey, “Chest radiographs and machine learning – Past, present and future,” Journal of Medical Imaging and Radiation Oncology, Vol. 65, No. 5, pp. 538 – 544, 2021. John Wiley and Sons Inc. Available: https://doi.org/10.1111/1754-9485.13274.
- Wang, Y. and Hargreaves, C. A. “A Review Study of the Deep Learning Techniques used for the Classification of Chest Radiological Images for COVID-19 Diagnosis,” 2022. Available: https://www.sciencedirect.com/science/article/pii/S266709682200043X.
- S. Motamed, P. Rogalla and F. Khalvati, “Data augmentation using Generative Adversarial Networks (GANs) for GAN-based detection of Pneumonia and COVID-19 in chest X-ray images,” Informatics in Medicine Unlocked, Vol. 27, No. 100779, pp. 1 – 7, 2021. Available: https://doi.org/10.1016/j.imu.2021.100779.
- H. Kamrul, M. AshrafulAlam, L. Dahal, M. E. ToufickElahi, S. Roy, W. S. Redwan R. Martí. and B. Khanal, “Challenges of Deep Learning Methods for COVID-19 Detection Using Public Datasets,” Informatics in Medicine Unlocked, Vol. 30, No. 100945, pp. 1 – 11, 2022. Available: https://doi.org/10.1101/2020.11.07.20227504.
- D. Meedeniya, K. Hashar, K. Shammi, F. Chamodi, D. Isabel and M. Gonçalo, “Chest X-ray analysis empowered with deep learning: A systematic review,” Applied Soft Computing, Vol. 126, No. 109319, pp. 1 – 20, 2022. Available: https://pmc.ncbi.nlm.nih.gov/articles/PMC9393235/pdf/main.pdf.
- G. H. Huang, Q. J. Fu, M. Z. Gu, K. Y. Liu and T. B. Chen, “Deep Transfer Learning for the Multilabel Classification of Chest X-ray Images,” Diagnosis, Vol. 12, No. 1457, pp. 1 – 18, 2022. Available: https://doi.org/10.3390/diagnostics12061457.
- I. Sirazitdinov, M. Kholiavchenko, R. Kuleev and B. Ibragimov, “Data Augmentation for Chest Pathologies Classification,” In 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), Venice, Italy. pp. 1216 – 1219, 2019. doi: 10.1109/ISBI.2019.8759573.
- M. F. Ng and C. A. Hargreaves, “Generative Adversarial Networks for the Synthesis of Chest X-ray Images,” In 3rd International Electronic Conference on Applied Sciences, 1 – 15 December 2022, Vol. 31, pp. 84 – 90, 2023. Available: https://asec2022.sciforum.net/.
- Z. Keita, “What is a Convolutional Neural Network (CNN)?” Data Camp, pp. 1 – 6, Last updated 14th November, 2023. Retrieved on 15th February, 2025. Available [Online]: https://www.datacamp.com/tutorial/introduction-to-convolutional-neural-networks-cnns.
- F. Tariq, “Breaking Down the Mathematics Behind CNN Models: A Comprehensive Guide,” Medium, pp. 1 – 14. Last updated 2nd May, 2023. Retrieved on 15th February, 2025. Available [Online]: https://medium.com/@beingfarina/breaking-down-the-mathematics-behind-cnn-models-a-comprehensive-guide-1853aa6b011e.
- C. Leo, “The Math Behind Convolutional Neural Networks,” Medium, TDS Archive, pp. 1 – 43, Last update 9th April, 2024. Retrieved on 15th February, 2025. Available [Online]: https://medium.com/data-science/the-math-behind-convolutional-neural-networks-6aed775df076.
- G. H. Huang, Z. Liu, L. Van Der Maaten and K. Q. Weinberger, “Densely Connected Convolutional Networks,” In 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Honolulu, HI, USA, 2017, pp. 2261 – 2269, 2017. Available: doi: 10.1109/CVPR.2017.243.
- I. Ahmed, G. Jeon and A. Chehri, “An IoT-enabled smart health care system for screening of COVID-19 with multi layers features fusion and selection,” Computing (Special Issue Article), vol. 105, pp. 743 – 760, 2023. DOI: 10.1007/s00607-021-00992-0.
- M. Mujahid, F. Rustam, R. Álvarez, J. L. V. Mazón, I. D. L. T. Díez and I. Ashraf, “Pneumonia Classification from X-ray Images with Inception-V3 and Convolutional Neural Network,” Diagnostics, vol. 12, (2022): no. 1280, pp. 1 – 16, 2022. https://doi.org/10.3390/diagnostics12051280.
- L. I. Kesuma, Ermatita and Erwin, “ELREI: Ensemble Learning of ResNet, EfficientNet, and Inception-v3 for Lung Disease Classification based on Chest X-Ray Image,” International Journal of Intelligent Engineering and Systems,” vol. 16, no. 5, pp. 149 – 161, 2023. doi: 10.22266/ijies2023.1031.14.
- M. Zak and A. Krzyżak, “Classification of Lung Disease Using Deep Learning Models,” ICCS 2020, LNCS 12139, pp. 621 – 634, 2020. doi: https://doi.org/10.1007/978-3-030-50420-5_47.
- M. B. Hossain, S. M. H. S. Iqbal, M. M. Islam, M. N. Akhtar and I. H. Sarker, “Transfer learning with fine-tuned deep CNN ResNet50 model for classifying COVID-19 from chest X-ray images,” Informatics in Medicine Unlocked, vol. 30, no. 100916, 2022. doi: https://doi.org/10.1016/j.imu.2022.100916.
- M. K. U. Ahamed, M. M. Islam, M. A. Uddin, A. Akhter, U. K. Acharjee, B. K. Paul and M. A. Moni, “DTLCx: An Improved ResNet Architecture to Classify Normal and Conventional Pneumonia Cases from COVID-19 Instances with Grad-CAM-Based Superimposed Visualization Utilizing Chest X-ray Images,” Diagnostics, vol. 13(3), no. 551, pp. 1 – 28, 2023. doi: 10.3390/diagnostics13030551.
- D. F. O. Onah and H. R. Warsame, “Paediatric Pneumonia chest X-ray image classification with association to Lung cancer disease using ResNet50 Deep Learning Model,” In the Proceedings of the 2024 IEEE International Conference on Big Data (BigData), 15 – 18 December, 2024, Washington, DC, USA, 2024, pp. 8859 – 8861. doi: 10.1109/BigData62323.2024.10825759
- C. Panati, S. Wagner and S. Brüggenwirth, “Feature Relevance Evaluation using Grad-CAM, LIME and SHAP for Deep Learning SAR Data Classification,” In the Proceedings of the 2022 23rd International Radar Symposium (IRS), 12 – 14 September, 2022, Gdansk, Poland, pp. 457 – 462, 2022. Available [Online]: doi: 10.23919/IRS54158.2022.9904989.
- M. Ennab and H. Mcheick, “Advancing AI Interpretability in Medical Imaging: A Comparative Analysis of Pixel-Level Interpretability and Grad-CAM Models,” Machine Learning & Knowledge Extraction, vol. 7, no. 12, pp. 1 – 32, 2025. doi: https://doi.org/10.3390/make7010012.
- M. Zhu, B. Zang, L. Ding, T. Lei, Z. Feng and J. Fan, “LIME-Based Data Selection Method for SAR Images Generation Using GAN,” Remote Sensing, vol. 14, no. 204, pp. 1 – 14, 2022. doi: 10.3390/rs14010204.
- M. A. K. Raiaan, S. Sakib, N. M. Fahad, A. A. Mamun, M. A. Rahman, S. Shatabda and M. S. H. Mukta, “A Systematic Review of Hyperparameter Optimization Techniques in Convolutional Neural Networks,” Decision Analytics Journals, vol. 11, no. 100470, 2024. doi: https://doi.org/10.1016/j.dajour.2024.100470
10.57647/ijbbe.2025.0502.09