OICC Press Trends in Phytochemical Research 2588-3631 10 1 2026 04 30 Chemical Composition and Chemotypic Variability of Tanacetum persicum (Boiss.) Mozaff. (Asteraceae) Essential Oils: Insights from Microwave-Assisted Hydrodistillation in Combination with GC-MS Analysis 10.57647/tpr.2026.1001.06 EN Majid Mohammadhosseini Herbal Drugs Raw Materials Research Center (HDRMRC), Sha.C., Islamic Azad University, Shahrood, Iran; Department of Chemistry, Sha.C., Islamic Azad University, Shahrood, Iran https://orcid.org/0000-0002-3188-4924 Journal Article 2026 04 30 This study investigates the essential oil (EO) compositions of Tanacetum persicum (Boiss.) Mozaff. aerial parts collected from five alpine regions in Kerman Province, Iran, namely Hazar, Lalehzar, Jupar, Plovar, and Bahr Aseman mountains. Utilizing microwave-assisted hydrodistillation (MAHD) combined with gas chromatography-mass spectrometry (GC-MS), a total of 36 volatile constituents were identified, representing between 99.3% and 99.9% of the total oil profiles. The characterized chemical profiles revealed a predominant accumulation of oxygenated monoterpenes (OMs) across all sites. Accordingly, major constituents exhibited significant quantitative variation depending on geographic origin, notably borneol (13.8%-20.1%), bornyl acetate (10.1%-19.1%), linalool (11.4%-19.9%), 1,8-cineole (8.5%-13.1%), and cumin aldehyde (5.3%-14.1%). These findings highlight substantial chemotypic diversity and intraspecific metabolic adaptation driven by geographical and environmental heterogeneity across the high-altitude habitats of Kerman Province.