OICC Press Trends in Phytochemical Research 2588-3631 9 3 2025 09 15 Hypericum perforatum L. (Hypericaceae): Cultivation, diversity of biochemical composition, antimicrobial activities, active biomolecules and action mode-A review 154 168 10.57647/tpr.2025.0903.13 EN Hajar Afqir Laboratory of Natural Resources and Sustainable Development, Faculty of Science, Ibn Tofail University - Kenitra, Kingdom of Morocco; Department of Plant and Environment Protection, National School of Agriculture, BP S/40 50 000 Meknes, Morocco Saadia Belmalha Department of Plant and Environment Protection, National School of Agriculture, BP S/40 50 000 Meknes, Morocco Jihane Laarifi Laboratory of Natural Resources and Sustainable Development, Faculty of Science, Ibn Tofail University - Kenitra, Kingdom of Morocco Ayoub Farihi Laboratory of Biology and Health, Biology Department, Ibn Tofail University, Faculty of Sciences, Morocco; Oriental Center for Water and Environmental Sciences and Technologies (COSTE), Mohammed Premier University, Oujda 60000, Morocco Soumaya Baataoui Laboratory of Natural Resources and Sustainable Development, Faculty of Science, Ibn Tofail University - Kenitra, Kingdom of Morocco Brahim Bourkhiss Laboratory of Animal Plant Production and Agro-Industry, Department of Biology, Faculty of Sciences, Ibn Tofail University, B.P. 133, Kenitra 14000, Morocco Hassane Tahiri Faculty of Science, Department of Biology, Ibn Tofail University, 14000, Kenitra, Morocco Mohammed Ouhssine Laboratory of Natural Resources and Sustainable Development, Faculty of Science, Ibn Tofail University - Kenitra, Kingdom of Morocco Journal Article 2025 09 15 This study analyses the knowledge on the cultivation, diversity, and variation of phytochemical constituents of essential oils and crude extracts from Hypericum perforatum. Equally, we presented a detailed discussion of the antimicrobial activities against pathogens and viruses, and the implicated biomolecules. A complete and organized literature search was carried out in the basic databases. According to the reviewed papers, Hypericum perforatum contains considerable amounts of chemical constituents, including phenolic, flavonoid, and terpene compounds, which are diverse and variable depending on the geography of plants, parts used, and extraction methods. These chemical constituents demonstrated serious inhibitory effects against fungi, bacteria, and viruses.