OICC Press Trends in Phytochemical Research 2588-3631 9 2 2025 09 27 Phenolic composition and antioxidant capacity of leaves infusions of Annona muricata L. (Annnonaceae) from two regions of Mexico 10.57647/tpr.2025.0902.09 EN Claudia Grijalva-Verdugo Departamento de Posgrado, Tecnológico Nacional de México/I. T. Roque, Km. 8 Carretera Celaya-Juventino Rosas, Celaya, Guanajuato, 38110, México; Programa de Biotecnología, Universidad de Guanajuato. Mutualismo #303, Colonia La Suiza, Celaya, Guanajuato, 38060, México Salvador Horacio Guzmán-Maldonado Campo Experimental Bajío, INIFAP, Km 6.5 Carretera Celaya-San Miguel de Allende, Celaya, Guanajuato, 38110, México César Leobardo Aguirre-Mancilla Departamento de Posgrado, Tecnológico Nacional de México/I. T. Roque, Km. 8 Carretera Celaya-Juventino Rosas, Celaya, Guanajuato, 38110, México Carlos Alberto Núñez-Colin Programa de Biotecnología, Universidad de Guanajuato. Mutualismo #303, Colonia La Suiza, Celaya, Guanajuato, 38060, México Juan Carlos Raya-Pérez Departamento de Posgrado, Tecnológico Nacional de México/I. T. Roque, Km. 8 Carretera Celaya-Juventino Rosas, Celaya, Guanajuato, 38110, México Jesús Rubén Rodríguez-Núñez Programa de Biotecnología, Universidad de Guanajuato. Mutualismo #303, Colonia La Suiza, Celaya, Guanajuato, 38060, México Journal Article 2025 09 27 Annona muricata L. (soursop) is a fruit of great economic importance and one of the plants most used in alternative medicine for its phytochemical composition. This work evaluates the phenolic composition and antioxidant capacity of infusions from Annona muricata leaves of three different ecotypes from two regions of Mexico. The infusions were characterized for total soluble phenolics, flavonoids, condensed tannins, total anthocyanins, and the antioxidant capacity was evaluated using different assays. The infusions of the analyzed ecotypes showed differences in polyphenol content and antioxidant activity. A positive relation between phenols and antioxidant capacity was observed for ABTS, FRAP, and ORAC. Epigallocatechin gallate (1.22-6.49 mg/g), rutin (3.47-8.73 mg/g), ellagic acid (5.25-14.13 mg/g), epicatechin (0.83-7.57 mg/g), and chlorogenic phenolic acids (4.42 mg/g) were quantified by HPLC. The infusion of leaves of the different soursop ecotypes showed differences in phenolic composition, antioxidant capacity and phenolic acids.