OICC Press Trends in Phytochemical Research 2588-3631 8 4 2024 12 30 Two new meroterpenoids from the gum resin of Ferula ammoniacum (D.Don) Spalik, M.Panahi, Piwczyński & Puchałka 226 233 10.71596/tpr.2024.1129453 EN Maryam Kharatha Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran Mahdi Moridi Farimani Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran Mostafa Alilou Department of Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria Journal Article 2024 12 30 The gum of Ferula ammoniacum (D.Don) Spalik, M.Panahi, Piwczyński & Puchałka is an herbal remedy used in traditional medicines for its effectiveness against various ailments. The phytochemical analysis of the ethyl acetate extract of the gum ammoniacum led to the discovery of two novel meroterpene derivatives 1 and 2. The structural elucidation of these isolated compounds was accomplished though 1D and 2D NMR spectroscopy, and HRESIMS, alongside comparison with existing literature data. Compound 1 represents a previously unreported meroterpenoid with a unique natural skeleton. A plausible biosynthetic pathway for this compound has also been proposed.