OICC Press Trends in Phytochemical Research 2588-3631 8 2 2024 09 21 Antioxidant properties and anticancer activity of Olea europaea L. olive and Ficus carica fruit extracts against pancreatic cancer cell lines 80 92 10.71596/tpr.2024.1126043 EN Nadia Dekdouk Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie Souad Ameddah Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie Chawki Bensouici Biotechnology Research Center (CRBt), Ali Mendjli, Constantine, Algérie Meghboun Ibtissem Biotechnology Research Center (CRBt), Ali Mendjli, Constantine, Algérie Menad Ahmed Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Université des Frères Mentouri Constantine1, Algérie Fatima Martel Unit of Biochemistry, Dept. of Biomedicine Faculty of Medicine of Porto 4200-319 Porto portugal Journal Article 2024 09 21 Olea europaea (OFE) and Ficus carica (FFE) extracts have shown anticancer activity. In the currents report, we aim to evaluate the phytochemical composition, antioxidant properties and anticancer activity of OFE and FFE against PANC-1 and AsPC-1 pancreatic cancer cell lines. OFE possessed higher phenolic, flavonoid content and antioxidant ability than FFE. OFE and FFE induced a cytotoxic effect and their combination resulted in an increased cytotoxicity. OFE showed an antiproliferative effect while FFE had no effect. Combination of the two extracts resulted in an antiproliferative effect similar to that of OFE. OFE showed an antimigratory effect, while FFE exhibited a promigratory effect. Interestingly, combination of the two extracts resulted in an anti-migratory effect similar to that caused by OFE. In view of the findings of this study, these extracts could be considered potential sources of natural compounds with antioxidant and anti-pancreatic cancer effects. The combination of these extracts should be further investigated in the context of pancreatic cancer.