OICC Press Trends in Phytochemical Research 2588-3631 7 1 2023 03 01 Enrichment of polyphenolic compounds from grape leaf extract (Vitis vinifera L.) using macroporous resin and investigating its adsorption kinetics and dynamics 58 65 10.30495/tpr.2023.1982639.1329 EN Nadia Sobhani Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran Mahshad Shahriari Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran Mohammad Hossein Jabbari Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran Samad Nejad Ebrahimi Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran Journal Article 2023 03 01 Vitis vinifera L. with common name of grape is native to Mediterranean region and today is grown all over the world.آHere, the adsorption/desorption process on LXA-10 resin was investigated to enrich polyphenolic compounds of grape extract. The extract was obtained using ultra-sound-assisted probe with water and ethanol (50:50) with an extraction yield of 26.4%. The pH value of the extract for maximum adsorption was optimized at 3.26. According to the findings of this study, the kinetic adsorption fitted well with pseudo-second-order model (R2=0.99). Moreover, the dynamic study revealed the adsorption capacity and required solvent for polyphenolic desorption being 42 mL and six-bed volume (BV), respectively. In the enriched powder, the amount of quercetin-O-3-glucuronide and quercetin-O-3-glucoside increased from the ranges of 19.43 to 45.92 mg.g-1 and 41.244 to 72.88 mg.g-1, respectively. The antioxidant activity of enriched polyphenols also increased from 252.37 in initial grape extract to 408.03 mM iron (II).mg-1.