OICC Press Trends in Phytochemical Research 2588-3631 5 1 2021 03 01 A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae) 31 36 EN Gervais Mouthe Happi Department of Chemistry, Higher Teacher Training College, University of Bamenda, P.O Box 39, Bambili, Cameroon|Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany Alexis Sylvain W. Mbobda Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon Marcel Frese Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany Simeon Fogue Kouam Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon Jean Claude Tchouankeu Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon Bruno Ndjakou Lenta Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon Norbert Sewald Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany Journal Article 2021 03 01 A new phenylpropanoid glycoside named psorospermoside (1) possessing an allose unit was isolated from the Psorospermum tenuifolium Hook f. bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR, and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 µM and 19.0µM, respectively. Furthermore, the chemotaxonomic significance of the isolated compounds was also discussed.