OICC Press Trends in Phytochemical Research 2588-3631 3 2 2019 06 01 Chemical constituents from the leaves and liana of Salacia nitida (Benth.) N.E.Br. (Celastraceae) and their antimicrobial activities 83 90 EN Brice Mba’ning Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon Joël E. T. Ateba Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon Angelbert F. Awantu Department of Chemistry, Faculty of Science, University of Bamenda, Po. Box 39, Bambili, Cameroon Luciana S. Amaral Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil Gervais M. Happi Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Po. Box 47, Yaoundé, Cameroon Beate Neumann Inorganic Chemistry, Department of Chemistry, Faculty of Chemistry, Bielefeld University, University str. 25, Bielefeld, Germany Georg Stammler Inorganic Chemistry, Department of Chemistry, Faculty of Chemistry, Bielefeld University, University str. 25, Bielefeld, Germany Bruno Lenta Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Po. Box 47, Yaoundé, Cameroon Silvère A. Ngouela Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon Iran Malavazi Departamento de Genética e Evolução, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil Etienne Tsamo Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon Norbert Sewald Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Po. Box 100131, D-33501 Bielefeld, Germany Edson Rodrigues-Filho Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil Journal Article 2019 06 01 One benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol-3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21) and stigmasterol (22), 21-hydroxyfriedelan-3-one (23), abruslactone A (24), and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)-(11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC = 23.8 µM) while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC = 53.8 µM) and Candida glabrata (MIC = 105.9 µM), respectively.