OICC Press Trends in Phytochemical Research 2588-3631 1 4 2017 12 01 Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae) 235 242 EN Jean Jules Kezetas Bankeu Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon | International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan Amadou Dawé Department of Chemistry, Higher Teacher Training College, University of Maroua, P.O. Box 55 Maroua, Cameroon Marius Mbiantcha Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon Guy Raymond Feuya Department of Chemistry, Faculty of Science, Scientific and Technical University of Masuku, Box. 943, Franceville, Gabon Iftikhar Ali Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan Marthe Aimée Tchuente Tchuenmogne Department of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Lateef Mehreen Pharmaceutical Research Centre of Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan Bruno Lenta Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon Muhammad Ali International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan Augustin Silvère Ngouela Department of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Journal Article 2017 12 01 Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity.