OICC Press Trends in Phytochemical Research 2588-3631 1 3 2017 09 01 Antiallergic polyphenols from Citharexylum spinosum 129 134 EN Ahmed E. Allam Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University 812-8581, Japan | Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt Journal Article 2017 09 01 Three polyphenolic compounds; 1,3,6-tri-O-galloyl-β-D-glucopyranose (TGG) (1), methyl gallate (2) and hydroxyquinol (3) have been isolated from the aerial parts of Fiddlewood Citharexylum spinosum L. The structure of the isolated compounds have been established on the basis of spectroscopic methods in addition to comparison with literature data. These compounds in addition to the methanol extract were tested against their antiallergic activity through inhibition of β-hexosaminidase enzyme. It was noticed that all tested compounds and methanol extract have good inhibition for β-hexosaminidase release without affecting the cell viability where the production of β-hexosaminidase was decreased to about 69%, 60% and 56% by compounds (1), (2) and (3) respectively. The antiallergic activity of Fiddlewood has been reported for the first time.