OICC Press Progress in Biomaterials 2194-0517 13 03 2024 09 30 The Hidden Glory of Nature in Burn Wound Treatment: Electrospinning Gelatin/PVA Nanofibers Loaded with Methanolic Clove Extract for Burn Wound Healing 10.57647/pibm.2024.132410 EN Boshra Doryab Department of Biomedical Engineering, Semnan University, Semnan, Iran Shahrokh Shojaei Department of Biomedical Engineering, CT.C., Islamic Azad University, Tehran, Iran Journal Article 2024 09 30 This study focused on the design and fabrication of a composite nanofibrous dressing based on gelatin and polyvinyl alcohol (PVA)  loaded with clove methanolic extract using the electrospinning technique. The scaffolds were cross-linked with glutaraldehyde vapor and characterized for their morphological, chemical, and mechanical properties by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and tensile testing. The results demonstrated that the fabricated dressings exhibited a uniform nanofibrous structure, suitable mechanical strength, and high-water absorption capacity. Moreover, the incorporation of clove methanolic extractsignificantly enhanced the antibacterial activity of the dressing, particularly against Gram-positive bacterial strains, and accelerated the healing process of burn wounds in an animal model. These findings suggest that this biocompatible and antibacterial dressing holds great potential as an innovative and effective therapeutic approach for burn wound management.