OICC Press Progress in Biomaterials 2194-0517 10 3 (September 2021) 2021 08 09 Magnetic dual-responsive semi-IPN nanogels based on chitosan/PNVCL and study on BSA release behavior 10.1007/s40204-021-00161-8 EN Hamed Mohammad Gholiha Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, IR Morteza Ehsani Department of polymer processing, Iran polymer and petrochemical institute (IPPI), Tehran, IR Department of Polymer Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, Tehran, IR Ardeshir Saeidi Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, IR Azam Ghadami Department of Chemical and Polymer Engineering, Central Tehran Branch, Islamic Azad University, Tehran, IR Najmeh Alizadeh Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, IR Journal Article 2021 08 09 Abstract Magnetic thermoresponsive nanogels present a promising new approach for targeted drug delivery. In the present study, bovine serum albumin (BSA) loaded thermo-responsive magnetic semi-IPN nanogels (MTRSI-NGs) were developed. At first poly( N -vinyl caprolactam) (PNVCL) was synthesized by free radical polymerization and then MTRSI-NGs were prepared by crosslinking chitosan in presence of chitosan and Fe 3 O 4 . The formation of MTRSI-NGs has been confirmed by FTIR, and the average molecular weight of PNVCL was determined by GPC analysis. Rheological and turbidimetry analysis were used to determine lower critical solution temperature (LCST) of PNVCL and magnetic thermo-responsive nanogels (MTRSI-NGs) around 32 and 37 °C, respectively. FE-SEM analysis showed particle size at less than 20 nm in the dried state. Dynamic light scattering determined particle size at about 30 nm in a swelling state. The analysis of release behavior showed that the BSA release ratio at 40 °C was faster than 25 °C. The pH release behavior was evaluated at pH 5.5 and 7.4 and showed that the drug release rate at pH 5.5 was more rapid than pH 7.4. The results show MTRSI-NGs are applicable to protein targeted delivery by thermosensitive targeted drug delivery systems.