10.1007/s40204-023-00219-9

Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract

  • Leena V. Hublikar1,
  • Sharanabasava V. Ganachari*2,
  • Veerabhadragouda B. Patil3,
  • Sahana Nandi4,
  • Aishwarya Honnad4,
  1. Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, 580031, IN Department of Chemistry and Research Centre, NMKRV College for Women, Bangaluru, 560011, IN Department of Chemistry, KLE’s P. C. Jabin Science College, Hubballi, 580031, IN
  2. Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, 580031, IN
  3. Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, Pardubice, 53210, CZ
  4. Department of Chemistry, KLE’s P. C. Jabin Science College, Hubballi, 580031, IN

Published 2023-04-24

How to Cite

Hublikar, L. V., Ganachari, S. V., Patil, V. B., Nandi, S., & Honnad, A. (2023). Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract. Progress in Biomaterials, 12(2 (June 2023). https://doi.org/10.1007/s40204-023-00219-9
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Abstract

Abstract A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50–90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.

Keywords

  • Green synthesis,
  • Lantana camara,
  • Silver nanoparticles,
  • Antibacterial,
  • Anticancer

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