OICC Press Journal of Theoretical and Applied Physics 2251-7235 18 2 2024 03 10 Inhibition breast cancer by (Cu-Se) nanoparticles generated by plasma jet 10.57647/j.jtap.2024.1802.26 EN Doaa Rifaat Jassim Department of Physics, College of Science for Women,,University of Baghdad, Baghdad, Iraq Ban H. Adil Department of Physics, College of Science for Women,,University of Baghdad, Baghdad, Iraq Ramiz Ahmed Al-ansari Department of Physics, College of Science for Women,,University of Baghdad, Baghdad, Iraq Journal Article 2024 03 10 This work discusses the synthesis of (Cu-Se) core-shell nanoparticles using a plasma jet, using aqueous solutions of copper and selenium salts as a precursor. The structural properties of the resultant (Cu-Se) core-shell nanostructures were examined using UV, XRD, and SEM. The diameter of the granules with a concentration of 3:7 is 17 nm. Thus, utilising the designated diameter. Next, a comparison was made between the MDA cell line—which had been treated to Cu-Se NPs as an anti-cancer (breast cancer) agent—and the normal cell line REF. For every set, the following parameter was evaluated: (i) the proportion of breast cancer cells whose proliferation was inhibited after exposure for (24, 48) hours; (ii) the cytotoxicity of normal cells after (24, 48) hours. We diluted the nanomaterial five times and found that the cytotoxicity in normal cells does not exceed 22%, indicating that its effect is not detrimental to normal cells. Meanwhile, the nanomaterial's effects were observed on cancer cells after 24 hours, at roughly 63%, and after 48 hours, at roughly 93%, and the census was carried out with these cells.