Gold-capped Fe3O4 nanoparticles with a magnetic field by damaging their DNA and generating more oxygen radicals, colon cancer cells can be made to die
Authors
Abstract
Using a hydrothermal technique, the gold (Au)-capped magnetite nanoparticles (Fe3O4) in the current work were created. TEM, SEM and FTIR were used to analyze the characteristics of the Fe3O4-Au MNPs and confirm the accuracy of the synthesized Fe3O4-Au. The size range of (5 – 15) nm was observed for Fe3O4–Au. By using the MTT assay, the impact of Fe3O4-Au on the proliferation of colon cancer (HT-29) cells was evaluated. Additionally, the cytotoxicity effects of Fe3O4-Au on (HT-29) cells were evaluated in both the absence and presence of alternating magnetic field (AMF) and laser photothermal therapy. According to the findings, Fe3O4-Au caused (HT-29) cells’ proliferation to be inhibited, which led to their planned demise. Cytotoxic activity against (HT-29) cells increased when exposed to NIR laser irradiation, however greatly elevated cytotoxic activity was seen after being exposed to induction heating with AMF. With regard to photothermal therapy for cancer cells, the current studies indicate that Fe3O4-Au with NIR laser and AMF may be promising.
