OICC Press Journal of Nanostructure in Chemistry 2193-8865 16 2 2026 04 30 Electronic and Biocompatible Properties of Phosphorus- Doped 2D-Hexagonal Boron Nitride 10.57647/jnsc.2026.1602.06 EN Juliana Sales Osterno Leitão Advanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará – UFC, Campus do Pici, Fortaleza, CE ZIP Code, Brazil Allysson Rocha Lima Advanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará – UFC, Campus do Pici, Fortaleza, CE ZIP Code, Brazil Tiago Melo Freire Advanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará – UFC, Campus do Pici, Fortaleza, CE ZIP Code, Brazil João Felipe da Silva Barros Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Campus of Pici, Fortaleza, Ceará, Brazil Antoninho Valentini Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Campus of Pici, Fortaleza, Ceará, Brazil Juan Símon Rodriguez Hernández Department of Physics, Federal University of Ceará-UFC, Campus of Pici, Fortaleza, Ceará, Brazil Alejandro Pedro Ayala Department of Physics, Federal University of Ceará-UFC, Campus of Pici, Fortaleza, Ceará, Brazil Tayná Vitória Ramos de Oliveira Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ, Brazil; Rio de Janeiro State University, Laboratory of Nanoradiopharmaceuticals and Strategic Materials, Rio de Janeiro, RJ, Brazil Ralph Santos-Oliveira Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ, Brazil; Rio de Janeiro State University, Laboratory of Nanoradiopharmaceuticals and Strategic Materials, Rio de Janeiro, RJ, Brazil Alan Silva de Menezes Department of Physics, Federal University of Maranhão, Campus Bacanga, São Luís, MA, Brazil Beatriz da Silva Batista Department of Physics, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, Campus Bacanga, São Luís, MA, Brazil Luciana Magalhães Rebêlo Alencar Department of Physics, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, Campus Bacanga, São Luís, MA, Brazil Luelc Souza da Costa Brazilian Nanotechonology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, Brazil Pierre Basílio Almeida Fechine Advanced Materials Chemistry Group (GQMat), Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará – UFC, Campus do Pici, Fortaleza, CE ZIP Code, Brazil https://orcid.org/0000-0002-7822-2354 Journal Article 2026 04 30 Hexagonal boron nitride (h-BN) has been considered one of the most promising nanomaterials currently available, mainly due to its structural stability, high optical band gap, and promising biocompatibility. In this work, pure h-BN and phosphorus-doped derivatives (h-BN-1P and h-BN-1.5P) were synthesized by pyrolysis followed by heat treatment at 1000 °C under a nitrogen stream. Structural characterization was performed by PXRD, FTIR, and Raman spectroscopy, confirming the formation of the hexagonal phase and demonstrating that phosphorus incorporation did not disrupt the crystal lattice. AFM and SEM analyses identified a mixture of topographies, including 2D (nanosheets) and 1D (nanowhisker) morphological structures, and EDS confirmed the incorporation of phosphorus. TEM analysis allowed obtaining the determination of interplanar distance values for the samples. Cytocompatibility was assessed in human umbilical vein endothelial cells (HUVECs) through the MTT viability assay. The results indicated that pure h-BN maintained cell viability above 85%, while phosphorus-doped materials showed a slight decrease in viability, but still preserved viability levels above 50% at the maximum concentration evaluated (100 µg mL-1). The results obtained confirm that h-BN and its phosphorus-doped forms exhibit favorable biocompatibility and tunable electronic properties, confirming their potential for future biomedical applications.