OICC Press Journal of Nanostructure in Chemistry 2193-8865 15 5 2025 10 17 A New Heterogeneous PMO@MXene Catalyst for One-Pot Synthesis of Substituted 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile Derivatives 10.57647/jnsc.2025.1505.19 EN Safa Hanifi Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, Rasht, Iran Farhad Shirini Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, Rasht, Iran Bahram Ramezanzadeh Department of Surface Coating and Corrosion, Institute for Color Science and Technology, Tehran, Iran Hassan Tajik Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, Rasht, Iran Journal Article 2025 10 17 In this study, we report the development of a novel and efficient MXene-based heterogeneous catalyst, PMO@MXene, for the green  synthesis of 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile derivatives. By integrating periodic mesoporous organosilica (PMO) into  multilayered MXene, a hybrid nanocomposite was achieved that benefits from the high surface area and electrical conductivity of MXene  along with the welldefined mesoporosity of PMO. This unique synergy enabled highly efficient catalytic performance under mild, eco-friendly conditions, requiring only a small amount of catalyst and allowing for easy recovery and reuse with minimal loss of activity. The  pyrazole derivatives, known for their potential pharmaceutical relevance, were obtained in excellent yields and characterized using  standard spectroscopic techniques. Importantly, this work highlights the potential of the PMO@MXene as a sustainable and recyclable  heterogeneous catalyst platform for the synthesis of biologically significant heterocyclic compounds.