OICC Press Journal of Nanostructure in Chemistry 2193-8865 8 4 (December 2018) 2018 10 20 Electrosynthesis of nano-sized pyran and chromene derivatives by one-pot reaction between cyclic-1,3-diketons, malononitrile/ethyl cyanoacetate, and isatins 10.1007/s40097-018-0282-5 EN Mohaddeseh Taheri Department of Science, South Tehran Branch, Islamic Azad University, Tehran, IR Behrooz Mirza Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, IR Mohsen Zeeb Department of Science, South Tehran Branch, Islamic Azad University, Tehran, IR Journal Article 2018 10 20 Abstract An efficient and sustainable method was developed for the electrocatalytic synthesis of nano-sized 4 H -pyran derivatives via a green, one-pot, three-component condensations of cyclic-1,3-diketones [including 1H-indene-1,3(2H)-dione, cyclohexane-1,3-dione, cyclopentane-1,3-dione, pyrimidine-2,4,6(1H,3H,5H)-trione], malononitrile or ethyl cyanoacetate, and isatins in an undivided electrochemically cell applying potassium bromide as the electrolyte in the alcoholic media. This electrosynthesis was introduced as a reliable and cost-effective approach for the high-yielding synthesis (76–92%) of the target compounds. The synthesized 4 H -pyran and chromene nanoparticles could open an effective way for production of nano-sized drugs. Graphical abstract