OICC Press Journal of Nanostructure in Chemistry 2193-8865 5 3 (September 2015) 2015 04 18 Evaluation of nicotine sensor based on copper nanoparticles and carbon nanotubes 10.1007/s40097-015-0154-1 EN Zohreh Goodarzi Department of Chemical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, IR Morteza Maghrebi Department of Chemical Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, IR Alireza Fakhari Zavareh Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran, IR Zahra-Beagom Mokhtari-Hosseini Chemical Engineering Group, Faculty of Petroleum and Petrochemical Engineering, Hakim Sabzevari University, Sabzevar, IR Bahman Ebrahimi-hoseinzadeh Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, IR Ashrafasadat Hatamian Zarmi Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, IR Mohammad Barshan-tashnizi Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, IR Journal Article 2015 04 18 Abstract An electrochemical sensor was prepared to detect nicotine by depositing copper nanoparticles (Cu NPs) on the surface of a glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes (MWNTs). The modified electrode was characterized by scanning electron microscopy and cyclic voltammetry. The novel-modified sensor exhibited effective electrocatalytic activities toward anodic oxidation of nicotine. Calibration plot showed two linear regions with different sensitivity, 1.121 ( r 2  = 0.982) in the range from 1 × 10 −6 to 9 × 10 −5  M and 0.164 ( r 2  = 0.982) from 1 × 10 −4  M up to 1 × 10 −3  M. The detection limit was 1 µM. For six parallel detections of 1 mM nicotine, the relative standard deviation was 5.68 %, suggesting that the film-modified electrode had good reproducibility. Experimental parameters affecting the sensor response such as pH, modifier concentration and electro-deposition scan rate were found to be optimum at 7.0, 2 mg mL −1 and 80 mV s −1 , respectively.