OICC Press Journal of Nanostructure in Chemistry 2193-8865 13 5 (October 2023) 2022 03 02 Combining 2D organic and 1D inorganic nanoblocks to develop free-standing hybrid nanomembranes for conformable biosensors 10.1007/s40097-022-00482-5 EN Jose García-Torres Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering and Research Center for Biomedical Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, ES Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Institut de Recerca Sant Joan de Déu, Barcelona, 08034, ES Carmen Lázaro Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Dioulde Sylla IREC-Catalonia Institute for Energy Research, Sant Adrià de Besòs, 08930, ES Sonia Lanzalaco Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Maria-Pau Ginebra Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering and Research Center for Biomedical Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, ES Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, 08028, ES Carlos Alemán Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, 08019, ES Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, 08028, ES Journal Article 2022 03 02 Abstract We report a simple approach to fabricate free-standing perforated 2D nanomembranes hosting well-ordered 1D metallic nanostructures to obtain hybrid materials with nanostructured surfaces for flexible electronics. Nanomembranes are formed by alternatively depositing perforated poly(lactic acid) (PLA) and poly(3,4-ethylenedioxythiophene) layers. Copper metallic nanowires (NWs) were incorporated into the nanoperforations of the top PLA layer by electrodeposition and further coated with silver via a transmetallation reaction. The combination of 2D polymeric nanomembranes and aligned 1D metallic NWs allows merging the flexibility and conformability of the ultrathin soft polymeric nanomembranes with the good electrical properties of metals for biointegrated electronic devices. Thus, we were able to tailor the nanomembrane surface chemistry as it was corroborated by SEM, EDX, XPS, CV, EIS and contact angle. The obtained hybrid nanomembranes were flexible and conformable showing sensing capacity towards H 2 O 2 with good linear concentration range (0.35–10 mM), sensitivity (120 µA cm −2  mM −1 ) and limit of detection (7 μm). Moreover, the membranes showed good stability, reproducibility and selectivity towards H 2 O 2 .