OICC Press Journal of Nanostructure in Chemistry 2193-8865 13 4 (August 2023) 2022 02 04 Novel eco-friendly acacia gum-grafted-polyamidoxime@copper ferrite nanocatalyst for synthesis of pyrazolopyridine derivatives 10.1007/s40097-022-00471-8 EN Fereshte Hassanzadeh-Afruzi Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR Ali Maleki Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR Ehsan Nazarzadeh Zare School of Chemistry, Damghan University, Damghan, 36716-41167, IR Journal Article 2022 02 04 Abstract A novel environmentally friendly polymer-based catalytic system was fabricated for the synthesis of biologically active pyrazolopyridine derivatives. Nanocatalyst was fabricated in three-step including (I) synthesis of the copper ferrite magnetic nanoparticles (MNPs) via co-precipitation method, (II) graft copolymerization of acrylonitrile onto acacia gum (AG) backbone using ammonium persulfate (APS) as an initiator, and N, N' -methylene bisacrylamide (MBA) as a crosslinker in combination with as-prepared copper ferrite, and (III) modification reaction of the as-prepared hydrogel using hydroxylamine hydrochloride reagent to achieve acacia gum- grafted - polyamidoxime/CuFe 2 O 4 (AG- g- PAO/CuFe 2 O 4 ) hydrogel nanocatalyst. The fabricated hydrogel nanocatalyst was well characterized by different techniques. The results revealed that the fabricated hydrogel nanocatalyst exhibited high thermal stability with ~ 40% char yield at 800 °C. The existence of many acidic and basic sites such as hydroxyl, carboxylic acid, amidoxime, amide, as well as Cu 2+ in three-dimensional cross-linked structure caused it was showed a great catalytic performance in the pyrazolopyridine derivatives synthesis. The various corresponding products were synthesized in remarkable yields (90–97%) without difficult work-up procedure in short reaction times (15–40 min). Furthermore, the hydrogel catalyst showed superparamagnetic behavior, so it could be magnetically collected from the reaction mixture and recycled for at least five successive cycles without considerable loss of activity. Graphical abstract