OICC Press Journal of Nanostructure in Chemistry 2193-8865 13 4 (August 2023) 2021 10 14 Synthesis of benzothiazole and benzimidazole derivatives via an eco-friendly method using piperazine immobilized on nano-ZnO-sulfuric acid as a powerful catalyst 10.1007/s40097-021-00450-5 EN Maryam Mousapour Department of Chemistry, College of Sciences, University of Guilan, Rasht, 41335-19141, IR Farhad Shirini Department of Chemistry, College of Sciences, University of Guilan, Rasht, 41335-19141, IR Journal Article 2021 10 14 Abstract In this research, the synthesis of piperazine immobilized on nano-ZnO-sulfuric acid (PINZS) as a new piperazine-based nano-reagent is reported. After identification of PINZS using different techniques including XRD (X-ray powder diffraction), TGA (thermogravimetric analysis), FT-IR (Fourier transform infrared spectroscopy), FESEM (field emission scanning electron microscopy), and EDX (energy-dispersive X-ray) analysis, this reagent is efficiently used for the synthesis of 1-(benzothiazolylamino) phenylmethyl-2-naphthols and pyrimido[1, 2-a]benzimidazoles via a domino Knoevenagel/Michael sequence which identified acceptable reaction times (7–45 min.), great yields (up to 98%) and ease of the preparation, separation, and recovery of PINZS (for three times) as the most important features of this protocol. Graphic abstract Use of PINZS in the synthesis of some important heterocycles.